SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r9p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3r9p ACKA
(Mycobacterium
avium) 		4 / 6 ASP A 343
LEU A 342
VAL A 341
ILE A 340
 None
 1.02A 1s9qA-3r9pA:
undetectable		 1s9qA-3r9pA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 3r9p ACKA
(Mycobacterium
avium) 		5 / 10 LEU A 367
GLY A 350
GLY A 351
PRO A 370
VAL A 369
 None
GOL  A 388 ( 3.7A)
None
None
None
 0.95A 1sdtA-3r9pA:
undetectable		 1sdtA-3r9pA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 3r9p ACKA
(Mycobacterium
avium) 		4 / 4 GLY A 339
SER A 362
VAL A 332
LEU A 305
 None
 1.10A 1yajB-3r9pA:
undetectable		 1yajB-3r9pA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 3r9p ACKA
(Mycobacterium
avium) 		4 / 5 CYH A 202
PRO A 221
THR A 371
THR A 317
 None
PGE  A 390 ( 4.6A)
None
None
 1.17A 1ymxB-3r9pA:
undetectable		 1ymxB-3r9pA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 3r9p ACKA
(Mycobacterium
avium) 		4 / 7 SER A 237
ASP A 235
LEU A 257
GLU A 254
 None
 0.97A 2cdqB-3r9pA:
undetectable		 2cdqB-3r9pA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 3r9p ACKA
(Mycobacterium
avium) 		5 / 12 LEU A 367
GLY A 350
GLY A 351
PRO A 370
VAL A 369
 None
GOL  A 388 ( 3.7A)
None
None
None
 0.91A 2r5pA-3r9pA:
undetectable		 2r5pA-3r9pA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 3r9p ACKA
(Mycobacterium
avium) 		5 / 12 LEU A 367
GLY A 350
GLY A 351
PRO A 370
VAL A 369
 None
GOL  A 388 ( 3.7A)
None
None
None
 0.90A 2r5pC-3r9pA:
undetectable		 2r5pC-3r9pA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 3r9p ACKA
(Mycobacterium
avium) 		4 / 5 ASN A 323
ARG A 355
ASN A 347
ALA A 326
 None
 1.49A 3frqA-3r9pA:
undetectable		 3frqA-3r9pA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 3r9p ACKA
(Mycobacterium
avium) 		4 / 7 PHE A 316
VAL A 366
ILE A 314
SER A 333
 None
 0.86A 3pglA-3r9pA:
undetectable		 3pglA-3r9pA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3r9p ACKA
(Mycobacterium
avium) 		5 / 11 ASN A 323
GLY A 319
ALA A 318
THR A 371
VAL A 176
 None
 1.21A 3rukD-3r9pA:
undetectable		 3rukD-3r9pA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 3r9p ACKA
(Mycobacterium
avium) 		4 / 5 LEU A 198
GLY A 199
PHE A 272
PHE A 293
 None
PGE  A 390 ( 4.4A)
None
None
 1.10A 3smtA-3r9pA:
undetectable		 3smtA-3r9pA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3r9p ACKA
(Mycobacterium
avium) 		3 / 3 LYS A 299
TYR A 300
ARG A 296
 EDO  A 389 ( 4.0A)
EDO  A 389 ( 4.0A)
None
 1.42A 4gc9A-3r9pA:
undetectable		 4gc9A-3r9pA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 3r9p ACKA
(Mycobacterium
avium) 		6 / 9 LEU A 338
VAL A 366
ILE A 314
ARG A 328
LEU A 196
ILE A 364
 None
None
None
GOL  A 388 ( 4.2A)
None
None
 1.16A 4kukA-3r9pA:
undetectable		 4kukA-3r9pA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3r9p ACKA
(Mycobacterium
avium) 		4 / 6 SER A 216
GLU A 223
GLY A 321
GLY A 199
 None
None
None
PGE  A 390 ( 4.4A)
 0.84A 5cdnA-3r9pA:
undetectable
5cdnB-3r9pA:
undetectable		 5cdnA-3r9pA:
23.90
5cdnB-3r9pA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3r9p ACKA
(Mycobacterium
avium) 		4 / 6 SER A 216
GLU A 223
GLY A 321
GLY A 199
 None
None
None
PGE  A 390 ( 4.4A)
 0.90A 5cdnR-3r9pA:
undetectable
5cdnS-3r9pA:
undetectable		 5cdnR-3r9pA:
23.90
5cdnS-3r9pA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 3r9p ACKA
(Mycobacterium
avium) 		5 / 12 LEU A 225
HIS A 173
GLY A 199
GLY A 228
HIS A 169
 None
None
PGE  A 390 ( 4.4A)
None
PGE  A 390 (-3.9A)
 1.24A 5nnaB-3r9pA:
undetectable		 5nnaB-3r9pA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3r9p ACKA
(Mycobacterium
avium) 		5 / 12 MET A 217
GLY A 218
TYR A 304
HIS A 197
PHE A 141
 PGE  A 390 (-3.8A)
None
None
PGE  A 390 (-4.2A)
None
 1.43A 5vscA-3r9pA:
undetectable		 5vscA-3r9pA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3r9p ACKA
(Mycobacterium
avium) 		5 / 12 MET A 217
GLY A 218
TYR A 304
HIS A 197
PHE A 141
 PGE  A 390 (-3.8A)
None
None
PGE  A 390 (-4.2A)
None
 1.41A 5vscB-3r9pA:
undetectable		 5vscB-3r9pA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3r9p ACKA
(Mycobacterium
avium) 		5 / 12 MET A 217
GLY A 218
TYR A 304
HIS A 197
PHE A 141
 PGE  A 390 (-3.8A)
None
None
PGE  A 390 (-4.2A)
None
 1.41A 5vseA-3r9pA:
undetectable		 5vseA-3r9pA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3r9p ACKA
(Mycobacterium
avium) 		5 / 12 MET A 217
GLY A 218
TYR A 304
HIS A 197
PHE A 141
 PGE  A 390 (-3.8A)
None
None
PGE  A 390 (-4.2A)
None
 1.41A 5vseB-3r9pA:
undetectable		 5vseB-3r9pA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 3r9p ACKA
(Mycobacterium
avium) 		3 / 3 HIS A 259
ASN A 258
LEU A 257
 None
 0.90A 6f7lB-3r9pA:
undetectable		 6f7lB-3r9pA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3r9p ACKA
(Mycobacterium
avium) 		4 / 8 ILE A 130
ALA A 123
VAL A 122
ARG A 124
 None
 1.02A 6hu9a-3r9pA:
undetectable
6hu9e-3r9pA:
0.4		 6hu9a-3r9pA:
21.95
6hu9e-3r9pA:
17.60