SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r9u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 11 LEU A  14
VAL A 290
ILE A  46
GLY A  58
ILE A  59
 None
FAD  A 501 (-4.0A)
FAD  A 501 (-4.3A)
None
None
 0.97A 1c6yA-3r9uA:
undetectable		 1c6yA-3r9uA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 11 LEU A  14
GLY A   9
GLY A   8
VAL A  81
HIS A  76
 None
FAD  A 501 (-4.5A)
FAD  A 501 (-3.2A)
FAD  A 501 (-3.9A)
None
 0.99A 1mx1A-3r9uA:
undetectable		 1mx1A-3r9uA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 9 LEU A  14
VAL A 290
ILE A  46
GLY A  58
ILE A  59
 None
FAD  A 501 (-4.0A)
FAD  A 501 (-4.3A)
None
None
 0.90A 1ohrB-3r9uA:
undetectable		 1ohrB-3r9uA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 GLY A  17
ALA A  16
GLY A  10
GLY A   9
ILE A 108
 None
None
FAD  A 501 (-3.3A)
FAD  A 501 (-4.5A)
None
 0.81A 2avvA-3r9uA:
undetectable		 2avvA-3r9uA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 11 ILE A   7
GLY A  34
GLU A  32
LEU A  96
GLY A   8
 None
None
FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.2A)
 1.35A 2fn1A-3r9uA:
undetectable		 2fn1A-3r9uA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 GLY A  17
ALA A  16
GLY A  10
GLY A   9
ILE A 108
 None
None
FAD  A 501 (-3.3A)
FAD  A 501 (-4.5A)
None
 0.84A 2fxeA-3r9uA:
undetectable		 2fxeA-3r9uA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		3 / 3 HIS A  76
MET A  70
MET A  30
 None
 1.34A 2vj1A-3r9uA:
undetectable		 2vj1A-3r9uA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		4 / 6 LEU A  96
SER A  91
ASP A  89
LYS A  95
 None
 1.09A 2vn1B-3r9uA:
undetectable		 2vn1B-3r9uA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 TYR A 171
PRO A 231
ALA A 214
ALA A 160
ALA A 164
 None
 0.97A 2x2nA-3r9uA:
undetectable		 2x2nA-3r9uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 GLY A  17
ALA A  16
GLY A  10
GLY A   9
ILE A 108
 None
None
FAD  A 501 (-3.3A)
FAD  A 501 (-4.5A)
None
 0.84A 3cyxB-3r9uA:
undetectable		 3cyxB-3r9uA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 9 LEU A  14
VAL A 290
ILE A  46
GLY A  58
ILE A  59
 None
FAD  A 501 (-4.0A)
FAD  A 501 (-4.3A)
None
None
 0.92A 3ekqB-3r9uA:
undetectable		 3ekqB-3r9uA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 CYH A 167
SER A 132
GLY A 130
ILE A 195
LEU A 163
 None
 1.45A 3iizA-3r9uA:
undetectable		 3iizA-3r9uA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 ASP A 281
GLY A  37
ALA A 293
ALA A 294
ASP A 296
 FAD  A 501 (-3.3A)
None
FAD  A 501 (-3.4A)
None
None
 1.04A 3keeA-3r9uA:
undetectable		 3keeA-3r9uA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 ASP A 281
GLY A  37
ALA A 293
ALA A 294
ASP A 296
 FAD  A 501 (-3.3A)
None
FAD  A 501 (-3.4A)
None
None
 1.01A 3keeC-3r9uA:
undetectable		 3keeC-3r9uA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 ASP A 281
GLY A  37
ALA A 293
ALA A 294
ASP A 296
 FAD  A 501 (-3.3A)
None
FAD  A 501 (-3.4A)
None
None
 1.02A 3keeD-3r9uA:
undetectable		 3keeD-3r9uA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		4 / 5 ILE A 233
PHE A 120
ASP A 204
GLU A 205
 None
 1.07A 3kp6A-3r9uA:
undetectable
3kp6B-3r9uA:
undetectable		 3kp6A-3r9uA:
17.03
3kp6B-3r9uA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		3 / 3 ASN A 240
ASN A 243
GLU A 244
 None
 0.91A 3kpdB-3r9uA:
undetectable		 3kpdB-3r9uA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 LEU A  14
VAL A 290
ILE A  46
GLY A  58
ILE A  59
 None
FAD  A 501 (-4.0A)
FAD  A 501 (-4.3A)
None
None
 0.98A 3spkB-3r9uA:
undetectable		 3spkB-3r9uA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 ASP A 281
GLY A  37
ALA A 293
ALA A 294
ASP A 296
 FAD  A 501 (-3.3A)
None
FAD  A 501 (-3.4A)
None
None
 0.92A 3sudD-3r9uA:
undetectable		 3sudD-3r9uA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		4 / 6 LEU A 282
ALA A 278
SER A 264
THR A 271
 None
 1.03A 4d7bB-3r9uA:
undetectable		 4d7bB-3r9uA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 11 ALA A 298
ALA A 300
ALA A 301
VAL A  28
LEU A  74
 None
 0.95A 4j6cA-3r9uA:
undetectable		 4j6cA-3r9uA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 10 ALA A 298
ALA A 300
ALA A 301
VAL A  28
LEU A  74
 None
 0.94A 4j6cB-3r9uA:
undetectable		 4j6cB-3r9uA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 ALA A 298
ALA A 300
ALA A 301
VAL A  28
LEU A  74
 None
 0.91A 4j6dA-3r9uA:
undetectable		 4j6dA-3r9uA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 ALA A 298
ALA A 300
ALA A 301
VAL A  28
LEU A  74
 None
 0.90A 4j6dB-3r9uA:
undetectable		 4j6dB-3r9uA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 ALA A 298
ALA A 300
ALA A 301
VAL A  28
LEU A  74
 None
 0.90A 4jbtA-3r9uA:
undetectable		 4jbtA-3r9uA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 11 ALA A 298
ALA A 300
ALA A 301
VAL A  28
LEU A  74
 None
 0.90A 4jbtB-3r9uA:
undetectable		 4jbtB-3r9uA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JXC_A_SAMA402_0
(FEFE-HYDROGENASE
MATURASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 CYH A 167
SER A 132
GLY A 130
ILE A 195
LEU A 163
 None
 1.46A 4jxcA-3r9uA:
undetectable		 4jxcA-3r9uA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 11 ALA A  20
TYR A  19
PHE A  72
SER A  15
GLY A  17
 None
 1.25A 4mmaA-3r9uA:
undetectable		 4mmaA-3r9uA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 GLY A  24
GLY A  23
ALA A 301
LEU A 302
GLY A  73
 None
 0.94A 4n09C-3r9uA:
4.0		 4n09C-3r9uA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 LEU A  14
VAL A 290
ILE A  46
GLY A  58
ILE A  59
 None
FAD  A 501 (-4.0A)
FAD  A 501 (-4.3A)
None
None
 1.01A 4njuA-3r9uA:
undetectable		 4njuA-3r9uA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 LEU A  14
VAL A 290
ILE A  46
GLY A  58
ILE A  59
 None
FAD  A 501 (-4.0A)
FAD  A 501 (-4.3A)
None
None
 1.00A 4njuC-3r9uA:
undetectable		 4njuC-3r9uA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 11 LEU A  14
VAL A 290
ILE A  46
GLY A  58
ILE A  59
 None
FAD  A 501 (-4.0A)
FAD  A 501 (-4.3A)
None
None
 0.93A 4qgiB-3r9uA:
undetectable		 4qgiB-3r9uA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		4 / 7 ALA A  16
SER A 113
GLY A 280
ALA A 279
 None
None
FAD  A 501 (-3.1A)
None
 0.84A 4r1zB-3r9uA:
undetectable		 4r1zB-3r9uA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 11 PHE A 234
GLY A 139
VAL A 147
SER A 132
GLY A 232
 None
 1.24A 4xnxA-3r9uA:
undetectable		 4xnxA-3r9uA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		4 / 8 ALA A 279
GLY A 297
ALA A  16
GLY A  13
 None
 0.62A 4zjzA-3r9uA:
undetectable		 4zjzA-3r9uA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 9 LEU A  14
VAL A 290
ILE A  46
GLY A  58
ILE A  59
 None
FAD  A 501 (-4.0A)
FAD  A 501 (-4.3A)
None
None
 0.86A 5kqxB-3r9uA:
undetectable		 5kqxB-3r9uA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 10 VAL A 230
GLU A 146
LEU A 150
ALA A 148
THR A 199
 None
 1.25A 5m5cE-3r9uA:
undetectable		 5m5cE-3r9uA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		4 / 5 ARG A 176
THR A 199
HIS A 174
ASP A 177
 None
 1.24A 5mfxA-3r9uA:
undetectable		 5mfxA-3r9uA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 ALA A 274
VAL A 273
ILE A   6
ALA A  16
ALA A 300
 None
 1.07A 5n5dB-3r9uA:
3.6		 5n5dB-3r9uA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 VAL A   4
LEU A 246
LEU A 276
ARG A 242
GLY A   9
 None
None
None
FAD  A 501 (-4.2A)
FAD  A 501 (-4.5A)
 1.02A 6b0iB-3r9uA:
undetectable		 6b0iB-3r9uA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 3r9u THIOREDOXIN
REDUCTASE
(Campylobacter
jejuni) 		5 / 12 LEU A  14
VAL A 290
ILE A  46
GLY A  58
ILE A  59
 None
FAD  A 501 (-4.0A)
FAD  A 501 (-4.3A)
None
None
 0.98A 6dilA-3r9uA:
undetectable		 6dilA-3r9uA:
13.58