SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3r9x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		5 / 12 GLU B  36
ASP B  62
ASP B  83
ASN B 101
PRO B 103
 None
 0.76A 1qaoA-3r9xB:
21.5		 1qaoA-3r9xB:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		5 / 11 GLU B  36
GLU B  60
ASP B  62
ASP B  83
PRO B 103
 None
 0.81A 2admA-3r9xB:
5.6		 2admA-3r9xB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		5 / 12 GLY B  42
ASN B  43
LEU B  61
ASP B  62
ASP B  83
 None
 1.33A 2b9eA-3r9xB:
14.7		 2b9eA-3r9xB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		5 / 11 GLU B  36
ILE B  59
GLU B  60
ASP B  83
ALA B  84
 None
 0.76A 3dxyA-3r9xB:
10.0		 3dxyA-3r9xB:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		7 / 12 VAL B  37
GLY B  38
GLU B  60
ASP B  62
ASP B  83
ALA B  84
PRO B 103
 None
 1.06A 3fuuA-3r9xB:
23.0		 3fuuA-3r9xB:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		6 / 11 GLU B  60
ASP B  62
ASP B  83
ALA B  84
ASN B 101
ILE B 110
 None
 1.37A 3grvA-3r9xB:
23.8		 3grvA-3r9xB:
33.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		6 / 11 GLU B  60
ASP B  62
ASP B  83
ALA B  84
ASN B 101
PRO B 103
 None
 0.99A 3grvA-3r9xB:
23.8		 3grvA-3r9xB:
33.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		6 / 11 GLY B  38
ASP B  62
ASP B  83
ALA B  84
ASN B 101
PRO B 103
 None
 1.24A 3grvA-3r9xB:
23.8		 3grvA-3r9xB:
33.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		8 / 12 GLU B  36
GLY B  38
GLU B  60
ASP B  62
ASP B  83
ALA B  84
ASN B 101
PRO B 103
 None
 1.15A 3gryA-3r9xB:
23.9		 3gryA-3r9xB:
33.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R9X_B_ACTB502_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		4 / 4 LYS B 130
GLU B 134
GLN B 137
TYR B 157
 ACT  B 502 (-3.5A)
ACT  B 502 (-4.3A)
ACT  B 502 (-4.2A)
ACT  B 502 (-3.5A)
 0.02A 3r9xB-3r9xB:
40.9		 3r9xB-3r9xB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		4 / 4 GLY B  38
GLY B  40
THR B  45
LEU B  69
 None
 0.94A 3si7C-3r9xB:
undetectable
3si7D-3r9xB:
undetectable		 3si7C-3r9xB:
23.59
3si7D-3r9xB:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		4 / 4 GLY B  39
GLY B  40
THR B  45
LEU B  69
 None
 0.88A 3si7C-3r9xB:
undetectable
3si7D-3r9xB:
undetectable		 3si7C-3r9xB:
23.59
3si7D-3r9xB:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		5 / 10 ILE B  59
LEU B  92
PHE B  89
ASN B 117
LYS B  55
 None
 1.49A 4eb4D-3r9xB:
undetectable		 4eb4D-3r9xB:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		4 / 4 LYS B 178
ASN B 156
VAL B 180
ASP B 154
 None
 1.24A 4fglD-3r9xB:
2.5		 4fglD-3r9xB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		3 / 3 GLU B  60
ASP B  62
ASP B  83
 None
 0.64A 4gc9A-3r9xB:
23.1		 4gc9A-3r9xB:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		3 / 3 ASP B  83
VAL B  79
ASN B 113
 None
 0.80A 4lmnA-3r9xB:
undetectable		 4lmnA-3r9xB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		4 / 6 GLY B 138
ARG B 150
PHE B 201
ARG B 204
 None
 1.40A 5jcnB-3r9xB:
2.4		 5jcnB-3r9xB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_B_6T0B304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		4 / 4 LYS B 178
ASN B 156
VAL B 180
ASP B 154
 None
 1.24A 5lbtB-3r9xB:
2.1		 5lbtB-3r9xB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3r9x RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A
(Aquifex
aeolicus) 		4 / 7 GLY B  38
GLU B  60
ASP B  83
ASN B 101
 None
 1.01A 5mvsA-3r9xB:
10.4		 5mvsA-3r9xB:
20.53