SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ram'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		4 / 6 PHE A  79
ILE A 155
LYS A 363
ALA A 366
 None
 1.23A 1hk2A-3ramA:
undetectable		 1hk2A-3ramA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 10 HIS A 341
LEU A  86
PRO A  87
ALA A  92
GLY A  94
 ZN  A 998 (-3.3A)
None
None
None
None
 1.37A 1mjqC-3ramA:
undetectable
1mjqD-3ramA:
undetectable		 1mjqC-3ramA:
13.52
1mjqD-3ramA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 11 HIS A 341
LEU A  86
PRO A  87
ALA A  92
GLY A  94
 ZN  A 998 (-3.3A)
None
None
None
None
 1.38A 1mjqI-3ramA:
undetectable
1mjqJ-3ramA:
undetectable		 1mjqI-3ramA:
13.52
1mjqJ-3ramA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		4 / 7 LEU A 250
ARG A 247
ASP A 171
GLY A 280
 None
 0.86A 1n13D-3ramA:
undetectable
1n13E-3ramA:
undetectable		 1n13D-3ramA:
14.97
1n13E-3ramA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		3 / 3 HIS A 330
HIS A 328
HIS A 156
 GOL  A 513 (-4.1A)
GOL  A 512 (-4.6A)
ZN  A 999 ( 3.3A)
 0.66A 1rjoA-3ramA:
undetectable		 1rjoA-3ramA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		3 / 3 HIS A 330
HIS A 328
HIS A 156
 GOL  A 513 (-4.1A)
GOL  A 512 (-4.6A)
ZN  A 999 ( 3.3A)
 0.64A 1rkyA-3ramA:
undetectable		 1rkyA-3ramA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 11 GLY A  94
ALA A 349
ALA A 348
LEU A 338
HIS A  26
 None
 1.15A 1ukbA-3ramA:
4.0		 1ukbA-3ramA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		3 / 3 HIS A 330
HIS A 328
HIS A 156
 GOL  A 513 (-4.1A)
GOL  A 512 (-4.6A)
ZN  A 999 ( 3.3A)
 0.71A 1w2zA-3ramA:
undetectable		 1w2zA-3ramA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		3 / 3 HIS A 330
HIS A 328
HIS A 156
 GOL  A 513 (-4.1A)
GOL  A 512 (-4.6A)
ZN  A 999 ( 3.3A)
 0.65A 1w2zB-3ramA:
undetectable		 1w2zB-3ramA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		3 / 3 HIS A 330
HIS A 328
HIS A 156
 GOL  A 513 (-4.1A)
GOL  A 512 (-4.6A)
ZN  A 999 ( 3.3A)
 0.66A 1w2zC-3ramA:
undetectable		 1w2zC-3ramA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		3 / 3 HIS A 330
HIS A 328
HIS A 156
 GOL  A 513 (-4.1A)
GOL  A 512 (-4.6A)
ZN  A 999 ( 3.3A)
 0.63A 1w2zD-3ramA:
undetectable		 1w2zD-3ramA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		4 / 7 TYR A  83
TYR A 140
HIS A  60
GLY A  59
 None
 1.24A 2ha4B-3ramA:
undetectable		 2ha4B-3ramA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		4 / 6 LEU A 104
VAL A 305
VAL A 301
ILE A 331
 None
 0.88A 2hyyA-3ramA:
undetectable		 2hyyA-3ramA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		4 / 5 LEU A 123
ILE A  65
ILE A  57
ALA A  58
 None
 0.75A 2i2zA-3ramA:
undetectable		 2i2zA-3ramA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		3 / 3 HIS A 330
HIS A 328
HIS A 156
 GOL  A 513 (-4.1A)
GOL  A 512 (-4.6A)
ZN  A 999 ( 3.3A)
 0.68A 2oqeA-3ramA:
undetectable		 2oqeA-3ramA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		3 / 3 HIS A 330
HIS A 328
HIS A 156
 GOL  A 513 (-4.1A)
GOL  A 512 (-4.6A)
ZN  A 999 ( 3.3A)
 0.68A 2oqeB-3ramA:
undetectable		 2oqeB-3ramA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		3 / 3 HIS A 330
HIS A 328
HIS A 156
 GOL  A 513 (-4.1A)
GOL  A 512 (-4.6A)
ZN  A 999 ( 3.3A)
 0.67A 2oqeC-3ramA:
undetectable		 2oqeC-3ramA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		3 / 3 HIS A 330
HIS A 328
HIS A 156
 GOL  A 513 (-4.1A)
GOL  A 512 (-4.6A)
ZN  A 999 ( 3.3A)
 0.68A 2oqeD-3ramA:
undetectable		 2oqeD-3ramA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		3 / 3 HIS A 330
HIS A 328
HIS A 156
 GOL  A 513 (-4.1A)
GOL  A 512 (-4.6A)
ZN  A 999 ( 3.3A)
 0.67A 2oqeF-3ramA:
undetectable		 2oqeF-3ramA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		4 / 8 HIS A  26
SER A  22
ASN A  96
ILE A  97
 None
 1.00A 2v57A-3ramA:
undetectable		 2v57A-3ramA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		4 / 8 HIS A  26
SER A  22
ASN A  96
ILE A  97
 None
 0.99A 2v57C-3ramA:
undetectable		 2v57C-3ramA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		3 / 3 HIS A 330
HIS A 328
HIS A 156
 GOL  A 513 (-4.1A)
GOL  A 512 (-4.6A)
ZN  A 999 ( 3.3A)
 0.61A 2w0qA-3ramA:
undetectable		 2w0qA-3ramA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		3 / 3 HIS A 330
HIS A 328
HIS A 156
 GOL  A 513 (-4.1A)
GOL  A 512 (-4.6A)
ZN  A 999 ( 3.3A)
 0.61A 2w0qB-3ramA:
undetectable		 2w0qB-3ramA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 12 ILE A 382
GLU A 371
SER A 102
LEU A  80
ILE A 151
 None
 1.20A 2xkwB-3ramA:
undetectable		 2xkwB-3ramA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 12 PRO A 126
GLY A  99
THR A 100
LEU A 123
VAL A 122
 None
 1.20A 2zifA-3ramA:
undetectable		 2zifA-3ramA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 12 PRO A 126
GLY A  99
THR A 100
LEU A 123
VAL A 122
 None
 1.20A 2zifB-3ramA:
undetectable		 2zifB-3ramA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		4 / 5 ASP A  50
ILE A 107
VAL A 122
THR A  55
 None
None
None
GOL  A 501 (-4.3A)
 1.14A 3eigA-3ramA:
undetectable		 3eigA-3ramA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		3 / 3 HIS A 330
HIS A 328
HIS A 156
 GOL  A 513 (-4.1A)
GOL  A 512 (-4.6A)
ZN  A 999 ( 3.3A)
 0.67A 3hiiA-3ramA:
undetectable		 3hiiA-3ramA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		3 / 3 HIS A 330
HIS A 328
HIS A 156
 GOL  A 513 (-4.1A)
GOL  A 512 (-4.6A)
ZN  A 999 ( 3.3A)
 0.67A 3hiiB-3ramA:
undetectable		 3hiiB-3ramA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		4 / 6 LEU A 104
VAL A 305
VAL A 301
ILE A 331
 None
 0.77A 3k5vA-3ramA:
undetectable		 3k5vA-3ramA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 12 ILE A  65
THR A  67
VAL A 145
ILE A 146
ILE A 149
 None
 1.14A 3kpbC-3ramA:
undetectable		 3kpbC-3ramA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 10 ILE A  65
THR A  67
VAL A 145
ILE A 146
ILE A 149
 None
 1.11A 3kpbD-3ramA:
undetectable		 3kpbD-3ramA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 11 ILE A  65
THR A  67
VAL A 145
ILE A 146
ILE A 149
 None
 1.11A 3kpcA-3ramA:
undetectable		 3kpcA-3ramA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 12 ILE A  65
THR A  67
VAL A 145
ILE A 146
ILE A 149
 None
 1.06A 3kpdB-3ramA:
undetectable		 3kpdB-3ramA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 12 ASP A 381
ILE A 383
ILE A 364
ILE A 151
TYR A 379
 None
 1.08A 3ohtA-3ramA:
undetectable
3ohtB-3ramA:
0.4		 3ohtA-3ramA:
21.26
3ohtB-3ramA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		3 / 3 GLU A  35
TYR A  83
SER A  39
 None
 0.98A 4at0A-3ramA:
undetectable		 4at0A-3ramA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 11 SER A 102
GLY A  99
ALA A 101
ILE A 327
HIS A 156
 None
None
None
None
ZN  A 999 ( 3.3A)
 1.07A 4dt8A-3ramA:
2.1		 4dt8A-3ramA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 12 HIS A 330
GLU A 303
ILE A 331
ASP A 355
GLY A 354
 GOL  A 513 (-4.1A)
None
None
None
None
 1.36A 4foxE-3ramA:
undetectable		 4foxE-3ramA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 11 HIS A 330
GLU A 303
ILE A 331
ASP A 355
GLY A 354
 GOL  A 513 (-4.1A)
None
None
None
None
 1.33A 4foxF-3ramA:
undetectable		 4foxF-3ramA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 11 HIS A 330
GLU A 303
ILE A 331
ASP A 355
GLY A 354
 GOL  A 513 (-4.1A)
None
None
None
None
 1.34A 4foxH-3ramA:
undetectable		 4foxH-3ramA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		3 / 3 HIS A 330
GLY A 313
ILE A 165
 GOL  A 513 (-4.1A)
GOL  A 512 ( 4.4A)
None
 0.48A 4k50A-3ramA:
undetectable		 4k50A-3ramA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		3 / 3 HIS A 330
GLY A 313
ILE A 165
 GOL  A 513 (-4.1A)
GOL  A 512 ( 4.4A)
None
 0.47A 4k50I-3ramA:
undetectable		 4k50I-3ramA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 11 HIS A  95
GLU A 128
GLU A 129
GLY A 313
HIS A 341
 ZN  A 999 (-3.3A)
GOL  A 512 (-3.2A)
ZN  A 998 ( 2.2A)
GOL  A 512 ( 4.4A)
ZN  A 998 (-3.3A)
 0.91A 4pqaA-3ramA:
24.7		 4pqaA-3ramA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 12 PHE A 274
GLY A 204
LEU A 208
VAL A 218
THR A 242
 None
 1.19A 4wnwA-3ramA:
undetectable		 4wnwA-3ramA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 11 TYR A 297
ILE A 327
ILE A 382
ILE A 113
ILE A 116
 None
 1.17A 5hw8A-3ramA:
undetectable
5hw8D-3ramA:
undetectable		 5hw8A-3ramA:
17.26
5hw8D-3ramA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 9 SER A 102
GLY A  78
ALA A  66
VAL A 121
ILE A 149
 None
 1.38A 5i3cA-3ramA:
4.2		 5i3cA-3ramA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 12 LEU A 123
ASP A 147
GLY A 144
ALA A 136
VAL A 320
 None
 1.20A 5kbwB-3ramA:
undetectable		 5kbwB-3ramA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		4 / 6 VAL A 103
TYR A  18
ARG A  45
HIS A  49
 None
 1.37A 5kkzA-3ramA:
undetectable
5kkzG-3ramA:
undetectable		 5kkzA-3ramA:
23.81
5kkzG-3ramA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 12 ALA A 366
VAL A 122
GLY A  99
ALA A  81
LEU A  46
 None
 1.45A 5x23A-3ramA:
undetectable		 5x23A-3ramA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 3ram HMRA PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A 320
VAL A 141
GLY A 130
THR A  62
GLY A  63
 None
None
GOL  A 516 (-3.2A)
None
None
 1.19A 6brdC-3ramA:
undetectable		 6brdC-3ramA:
11.83