SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rap'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 3rap PROTEIN (G PROTEIN
RAP2A)
(Homo
sapiens) 		3 / 3 PHE R  28
LEU R  19
SER R 146
 GTP  R 180 (-4.3A)
None
GTP  R 180 (-3.4A)
 0.75A 1e7aA-3rapR:
undetectable		 1e7aA-3rapR:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3rap PROTEIN (G PROTEIN
RAP2A)
(Homo
sapiens) 		4 / 6 TYR R   4
SER R  49
SER R  51
ASN R 165
 None
 1.15A 1yvpB-3rapR:
undetectable		 1yvpB-3rapR:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3rap PROTEIN (G PROTEIN
RAP2A)
(Homo
sapiens) 		5 / 12 THR R  35
GLY R  15
GLY R  13
GLY R  60
ASP R 119
 MG  R 200 ( 2.7A)
GTP  R 180 (-3.1A)
GTP  R 180 (-3.5A)
GTP  R 180 (-3.3A)
GTP  R 180 (-2.9A)
 0.96A 2b25A-3rapR:
2.3		 2b25A-3rapR:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 3rap PROTEIN (G PROTEIN
RAP2A)
(Homo
sapiens) 		5 / 12 GLU R 159
ARG R 162
ILE R  79
GLU R 155
ASP R  47
 None
 1.17A 2qeoA-3rapR:
undetectable		 2qeoA-3rapR:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3rap PROTEIN (G PROTEIN
RAP2A)
(Homo
sapiens) 		5 / 12 GLY R 115
THR R 145
PHE R  90
ILE R  93
LEU R 113
 None
 1.17A 3iv6A-3rapR:
undetectable		 3iv6A-3rapR:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 3rap PROTEIN (G PROTEIN
RAP2A)
(Homo
sapiens) 		3 / 3 GLU R  54
ARG R  41
GLN R  76
 None
 0.96A 4rtbA-3rapR:
undetectable		 4rtbA-3rapR:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 3rap PROTEIN (G PROTEIN
RAP2A)
(Homo
sapiens) 		4 / 8 ASP R 154
ALA R 158
VAL R 161
GLU R  45
 None
 0.87A 4zbqA-3rapR:
undetectable		 4zbqA-3rapR:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3rap PROTEIN (G PROTEIN
RAP2A)
(Homo
sapiens) 		4 / 8 ILE R  93
GLY R 115
THR R 145
LEU R 156
 None
 0.94A 5esfA-3rapR:
undetectable		 5esfA-3rapR:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3rap PROTEIN (G PROTEIN
RAP2A)
(Homo
sapiens) 		4 / 7 ILE R  93
GLY R 115
THR R 145
LEU R 156
 None
 0.97A 5esmA-3rapR:
undetectable		 5esmA-3rapR:
15.60