SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ray'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XRZ_A_ACTA1470_0 (DEOXYRIBODIPYRIMIDIN E PHOTOLYASE)	3ray	PR DOMAIN-CONTAINING PROTEIN 11 (Homo sapiens)	4 / 5	ARG A 141 ALA A 65 ASP A 63 GLU A 134	None	1.21A	2xrzA-3rayA: undetectable	2xrzA-3rayA: 19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U15_B_0HKB1201_2 (MUSCARINIC ACETYLCHOLINE RECEPTOR M3,LYSOZYME,MUSCARIN IC ACETYLCHOLINE RECEPTOR M3)	3ray	PR DOMAIN-CONTAINING PROTEIN 11 (Homo sapiens)	4 / 4	ASN A 138 TRP A 139 LEU A 177 PHE A 115	None	1.36A	4u15B-3rayA: undetectable	4u15B-3rayA: 18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DPD_A_SAMA601_0 (PROTEIN LYSINE METHYLTRANSFERASE 1)	3ray	PR DOMAIN-CONTAINING PROTEIN 11 (Homo sapiens)	5 / 12	GLU A 161 LEU A 118 SER A 128 ILE A 129 HIS A 159	None UNX A 238 ( 4.2A) None None None	1.04A	5dpdA-3rayA: undetectable	5dpdA-3rayA: 16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HD4_B_STIB602_1 (TYROSINE-PROTEIN KINASE ABL1)	3ray	PR DOMAIN-CONTAINING PROTEIN 11 (Homo sapiens)	4 / 6	LEU A 154 VAL A 120 PHE A 98 GLY A 95	None	0.96A	6hd4B-3rayA: undetectable	6hd4B-3rayA: 15.61

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2XRZ_A_ACTA1470_0","DEOXYRIBODIPYRIMIDINE PHOTOLYASE","3ray","PR DOMAIN-CONTAINING PROTEIN 11","Homo sapiens",4,"ARG A 141;ALA A  65;ASP A  63;GLU A 134","None","1.21A","2xrzA-3rayA:undetectable","2xrzA-3rayA:19.25"],["4U15_B_0HKB1201_2","MUSCARINIC ACETYLCHOLINE RECEPTOR M3,LYSOZYME,MUSCARINIC ACETYLCHOLINE RECEPTOR M3","3ray","PR DOMAIN-CONTAINING PROTEIN 11","Homo sapiens",4,"ASN A 138;TRP A 139;LEU A 177;PHE A 115","None","1.36A","4u15B-3rayA:undetectable","4u15B-3rayA:18.20"],["5DPD_A_SAMA601_0","PROTEIN LYSINE METHYLTRANSFERASE 1","3ray","PR DOMAIN-CONTAINING PROTEIN 11","Homo sapiens",5,"GLU A 161;LEU A 118;SER A 128;ILE A 129;HIS A 159","None;UNX A 238 ( 4.2A);None;None;None","1.04A","5dpdA-3rayA:undetectable","5dpdA-3rayA:16.48"],["6HD4_B_STIB602_1","TYROSINE-PROTEIN KINASE ABL1","3ray","PR DOMAIN-CONTAINING PROTEIN 11","Homo sapiens",4,"LEU A 154;VAL A 120;PHE A  98;GLY A  95","None","0.96A","6hd4B-3rayA:undetectable","6hd4B-3rayA:15.61"]]