SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rb5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 3rb5 NA/CA EXCHANGE
PROTEIN
(Drosophila
melanogaster) 		4 / 4 LYS A 656
LEU A 653
ALA A 655
LEU A 647
 None
 1.41A 1f86B-3rb5A:
undetectable		 1f86B-3rb5A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3rb5 NA/CA EXCHANGE
PROTEIN
(Drosophila
melanogaster) 		5 / 12 GLY A 606
LEU A 624
ILE A 622
HIS A 641
TRP A 592
 None
 1.18A 1kyvA-3rb5A:
undetectable
1kyvE-3rb5A:
undetectable		 1kyvA-3rb5A:
20.91
1kyvE-3rb5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3rb5 NA/CA EXCHANGE
PROTEIN
(Drosophila
melanogaster) 		5 / 12 HIS A 641
TRP A 592
GLY A 606
LEU A 624
ILE A 622
 None
 1.18A 1kyvB-3rb5A:
undetectable
1kyvC-3rb5A:
undetectable		 1kyvB-3rb5A:
20.91
1kyvC-3rb5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3rb5 NA/CA EXCHANGE
PROTEIN
(Drosophila
melanogaster) 		5 / 12 HIS A 641
TRP A 592
GLY A 606
LEU A 624
ILE A 622
 None
 1.18A 1kyvC-3rb5A:
undetectable
1kyvD-3rb5A:
undetectable		 1kyvC-3rb5A:
20.91
1kyvD-3rb5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3rb5 NA/CA EXCHANGE
PROTEIN
(Drosophila
melanogaster) 		5 / 12 HIS A 641
TRP A 592
GLY A 606
LEU A 624
ILE A 622
 None
 1.17A 1kyvD-3rb5A:
undetectable
1kyvE-3rb5A:
undetectable		 1kyvD-3rb5A:
20.91
1kyvE-3rb5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 3rb5 NA/CA EXCHANGE
PROTEIN
(Drosophila
melanogaster) 		4 / 7 ALA A 474
ILE A 442
ILE A 470
ASP A 469
 None
 0.93A 1yc5A-3rb5A:
undetectable		 1yc5A-3rb5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 3rb5 NA/CA EXCHANGE
PROTEIN
(Drosophila
melanogaster) 		4 / 5 ALA A 474
ILE A 442
ILE A 470
ASP A 469
 None
 0.94A 2h4jA-3rb5A:
undetectable		 2h4jA-3rb5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 3rb5 NA/CA EXCHANGE
PROTEIN
(Drosophila
melanogaster) 		4 / 4 LYS A 656
LEU A 653
ALA A 655
LEU A 647
 None
 1.32A 2roxA-3rb5A:
2.4		 2roxA-3rb5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 3rb5 NA/CA EXCHANGE
PROTEIN
(Drosophila
melanogaster) 		4 / 6 LYS A 656
LEU A 653
ALA A 655
LEU A 647
 None
 1.27A 5a6iA-3rb5A:
2.7		 5a6iA-3rb5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3rb5 NA/CA EXCHANGE
PROTEIN
(Drosophila
melanogaster) 		5 / 12 ILE A 556
GLY A 683
ASN A 682
HIS A 553
GLU A 521
 None
 1.22A 5igyA-3rb5A:
undetectable		 5igyA-3rb5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 3rb5 NA/CA EXCHANGE
PROTEIN
(Drosophila
melanogaster) 		4 / 6 LYS A 656
LEU A 653
ALA A 655
LEU A 647
 None
 1.27A 5l4iB-3rb5A:
2.9		 5l4iB-3rb5A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3rb5 NA/CA EXCHANGE
PROTEIN
(Drosophila
melanogaster) 		4 / 6 SER A 637
PHE A 638
ASP A 596
HIS A 641
 None
 1.23A 5om3A-3rb5A:
undetectable
5om3B-3rb5A:
undetectable		 5om3A-3rb5A:
14.63
5om3B-3rb5A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 3rb5 NA/CA EXCHANGE
PROTEIN
(Drosophila
melanogaster) 		4 / 6 PHE A 491
GLY A 493
THR A 480
GLN A 481
 None
 1.24A 6ag0C-3rb5A:
undetectable		 6ag0C-3rb5A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 3rb5 NA/CA EXCHANGE
PROTEIN
(Drosophila
melanogaster) 		4 / 4 LYS A 656
LEU A 653
ALA A 655
LEU A 647
 None
 1.49A 6gnrA-3rb5A:
2.1		 6gnrA-3rb5A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 3rb5 NA/CA EXCHANGE
PROTEIN
(Drosophila
melanogaster) 		4 / 4 LYS A 656
LEU A 653
ALA A 655
LEU A 647
 None
 1.49A 6gnrB-3rb5A:
undetectable		 6gnrB-3rb5A:
18.21