SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rb9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 304
ALA A 302
TYR A 326
GLU A 329
 None
 0.90A 1dmaA-3rb9A:
undetectable		 1dmaA-3rb9A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 306
MET A 299
VAL A 352
ILE A 284
 None
 0.79A 1e06A-3rb9A:
undetectable		 1e06A-3rb9A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 213
ASN A  32
TRP A  28
 None
 1.24A 1r15C-3rb9A:
undetectable		 1r15C-3rb9A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 213
ASN A  32
TRP A  28
 None
 1.29A 1r15D-3rb9A:
undetectable		 1r15D-3rb9A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 213
ASN A  32
TRP A  28
 None
 1.27A 1r15E-3rb9A:
undetectable		 1r15E-3rb9A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 213
ASN A  32
TRP A  28
 None
 1.28A 1r15F-3rb9A:
undetectable		 1r15F-3rb9A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 261
LEU A 172
LEU A 178
ALA A 179
 None
 0.97A 2vcvB-3rb9A:
undetectable		 2vcvB-3rb9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 301
LEU A 340
ALA A 363
ALA A 273
 None
 0.95A 2vcvB-3rb9A:
undetectable		 2vcvB-3rb9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 301
LEU A 340
ALA A 363
ALA A 273
 None
 0.91A 2vcvK-3rb9A:
undetectable		 2vcvK-3rb9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  89
THR A  90
LEU A 118
VAL A 100
GLU A 103
 None
 1.08A 2vn0A-3rb9A:
undetectable		 2vn0A-3rb9A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		4 / 5 ARG A  19
ALA A  23
ASP A  24
GLU A  20
 None
 1.24A 2xrzA-3rb9A:
undetectable		 2xrzA-3rb9A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 336
ALA A 291
ALA A 288
ALA A 310
 None
 0.89A 3a2qA-3rb9A:
undetectable		 3a2qA-3rb9A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		3 / 3 ILE A 171
SER A 196
SER A 194
 None
 0.54A 3iltH-3rb9A:
undetectable		 3iltH-3rb9A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 118
VAL A  81
SER A  82
VAL A 100
LEU A  54
 None
 1.31A 3m7rA-3rb9A:
undetectable		 3m7rA-3rb9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		5 / 9 VAL A 306
PHE A 301
THR A 341
VAL A 297
VAL A 287
 None
 1.20A 3me6D-3rb9A:
undetectable		 3me6D-3rb9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 306
GLN A 296
ILE A 284
MET A 275
 None
 0.98A 4iilA-3rb9A:
undetectable		 4iilA-3rb9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		3 / 3 CYH A 111
ASN A 113
LYS A  96
 None
 0.73A 4k50A-3rb9A:
undetectable		 4k50A-3rb9A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 189
LEU A 191
GLU A 190
 None
 0.64A 4l3gF-3rb9A:
undetectable		 4l3gF-3rb9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 322
VAL A 324
MET A 299
PHE A 354
VAL A 352
 None
 1.31A 4nc3A-3rb9A:
undetectable		 4nc3A-3rb9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 180
THR A 181
ALA A 154
VAL A 206
ALA A 208
 None
 0.95A 4qvnK-3rb9A:
undetectable
4qvnL-3rb9A:
undetectable		 4qvnK-3rb9A:
19.60
4qvnL-3rb9A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 180
THR A 181
ALA A 154
VAL A 206
ALA A 208
 None
 0.96A 4qvnY-3rb9A:
undetectable
4qvnZ-3rb9A:
undetectable		 4qvnY-3rb9A:
19.60
4qvnZ-3rb9A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		5 / 12 ARG A 168
ALA A 203
PHE A 261
ALA A 179
VAL A 188
 None
 1.45A 4ryaA-3rb9A:
undetectable		 4ryaA-3rb9A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		4 / 5 ALA A 278
HIS A 269
PRO A 367
PHE A 354
 None
 1.21A 4ze2A-3rb9A:
undetectable		 4ze2A-3rb9A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 147
GLU A 146
LEU A 139
LEU A 143
LEU A 178
 None
 1.19A 4zn7A-3rb9A:
undetectable		 4zn7A-3rb9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		5 / 7 LEU A 164
THR A 181
PRO A 259
LEU A 394
MET A 396
 None
 1.00A 5fxtA-3rb9A:
36.2		 5fxtA-3rb9A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		5 / 8 THR A 181
LEU A 186
PRO A 259
LEU A 394
MET A 396
 None
 0.66A 5g48A-3rb9A:
35.9		 5g48A-3rb9A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		5 / 8 THR A 181
LEU A 186
PRO A 362
LEU A 394
MET A 396
 None
 0.44A 5g48A-3rb9A:
35.9		 5g48A-3rb9A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		6 / 9 LEU A 164
THR A 181
PRO A 259
PRO A 362
LEU A 394
MET A 396
 None
 0.96A 5g48B-3rb9A:
35.9		 5g48B-3rb9A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		6 / 9 THR A 181
LEU A 186
PRO A 259
PRO A 362
LEU A 394
MET A 396
 None
 0.69A 5g48B-3rb9A:
35.9		 5g48B-3rb9A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 240
ILE A 242
ALA A 214
PHE A 144
 None
 0.92A 5m0oC-3rb9A:
undetectable		 5m0oC-3rb9A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		5 / 9 ILE A 148
VAL A 206
GLU A 213
ASN A  32
ILE A 242
 None
 1.16A 5mzpA-3rb9A:
undetectable		 5mzpA-3rb9A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 3rb9 DNA POLYMERASE III
SUBUNIT BETA
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 386
VAL A 387
GLY A 355
ALA A 271
TYR A 326
 None
 0.97A 5n5dA-3rb9A:
undetectable		 5n5dA-3rb9A:
20.35