SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rbl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 8 ALA A 151
LEU A 287
LEU A 243
THR A 245
 None
 0.98A 1dvtA-3rblA:
undetectable
1dvtB-3rblA:
undetectable		 1dvtA-3rblA:
12.88
1dvtB-3rblA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_B_BZMB600_0
(ODORANT-BINDING
PROTEIN)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 9 ILE A 260
MET A 239
ASN A 253
GLY A 258
LEU A 268
 None
 1.41A 1dzmB-3rblA:
undetectable		 1dzmB-3rblA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 5 HIS A 302
ALA A  88
SER A  85
HIS A  72
 None
 1.34A 1errA-3rblA:
undetectable
1errB-3rblA:
undetectable		 1errA-3rblA:
20.75
1errB-3rblA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 6 ARG A 397
ILE A 467
TRP A 464
GLU A 465
 None
 1.13A 1nsiA-3rblA:
undetectable
1nsiB-3rblA:
undetectable		 1nsiA-3rblA:
21.46
1nsiB-3rblA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 6 TRP A 464
GLU A 465
ARG A 397
ILE A 467
 None
 1.17A 1nsiA-3rblA:
undetectable
1nsiB-3rblA:
undetectable		 1nsiA-3rblA:
21.46
1nsiB-3rblA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 6 ARG A 397
ILE A 467
TRP A 464
GLU A 465
 None
 1.13A 1nsiC-3rblA:
undetectable
1nsiD-3rblA:
undetectable		 1nsiC-3rblA:
21.46
1nsiD-3rblA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 6 TRP A 464
GLU A 465
ARG A 397
ILE A 467
 None
 1.14A 1nsiC-3rblA:
undetectable
1nsiD-3rblA:
undetectable		 1nsiC-3rblA:
21.46
1nsiD-3rblA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 12 ALA A 185
GLY A 203
GLY A 202
LEU A 156
LEU A 157
 None
 0.90A 1ya4A-3rblA:
undetectable		 1ya4A-3rblA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 7 ARG A 397
ILE A 467
TRP A 464
GLU A 465
 None
 1.11A 2nsiA-3rblA:
undetectable
2nsiB-3rblA:
undetectable		 2nsiA-3rblA:
21.46
2nsiB-3rblA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 7 TRP A 464
GLU A 465
ARG A 397
ILE A 467
 None
 1.12A 2nsiA-3rblA:
undetectable
2nsiB-3rblA:
undetectable		 2nsiA-3rblA:
21.46
2nsiB-3rblA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 7 ARG A 397
ILE A 467
TRP A 464
GLU A 465
 None
 1.14A 2nsiC-3rblA:
undetectable
2nsiD-3rblA:
undetectable		 2nsiC-3rblA:
21.46
2nsiD-3rblA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 7 TRP A 464
GLU A 465
ARG A 397
ILE A 467
 None
 1.15A 2nsiC-3rblA:
undetectable
2nsiD-3rblA:
undetectable		 2nsiC-3rblA:
21.46
2nsiD-3rblA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 7 ARG A 397
ILE A 467
TRP A 464
GLU A 465
 None
 1.14A 3e7gA-3rblA:
undetectable
3e7gB-3rblA:
undetectable		 3e7gA-3rblA:
20.56
3e7gB-3rblA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 7 TRP A 464
GLU A 465
ARG A 397
ILE A 467
 None
 1.17A 3e7gA-3rblA:
undetectable
3e7gB-3rblA:
undetectable		 3e7gA-3rblA:
20.56
3e7gB-3rblA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 7 ARG A 397
ILE A 467
TRP A 464
GLU A 465
 None
 1.20A 3e7gC-3rblA:
undetectable
3e7gD-3rblA:
undetectable		 3e7gC-3rblA:
20.56
3e7gD-3rblA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 8 ASP A 189
SER A 188
SER A 250
CYH A 438
 None
 0.98A 3m0wE-3rblA:
undetectable
3m0wF-3rblA:
undetectable
3m0wG-3rblA:
undetectable
3m0wH-3rblA:
undetectable		 3m0wE-3rblA:
12.70
3m0wF-3rblA:
12.70
3m0wG-3rblA:
12.70
3m0wH-3rblA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 12 SER A 211
SER A 250
VAL A 445
VAL A 402
CYH A 438
 None
 1.06A 3u9fB-3rblA:
undetectable
3u9fC-3rblA:
undetectable		 3u9fB-3rblA:
18.50
3u9fC-3rblA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 12 SER A 211
SER A 250
VAL A 445
VAL A 402
CYH A 438
 None
 0.96A 3u9fH-3rblA:
undetectable
3u9fI-3rblA:
undetectable		 3u9fH-3rblA:
18.50
3u9fI-3rblA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 12 SER A 211
SER A 250
VAL A 445
VAL A 402
CYH A 438
 None
 1.04A 3u9fJ-3rblA:
undetectable
3u9fK-3rblA:
undetectable		 3u9fJ-3rblA:
18.50
3u9fK-3rblA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_M_CLMM221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 10 SER A 211
SER A 250
VAL A 445
VAL A 402
CYH A 438
 None
 1.03A 3u9fM-3rblA:
0.0
3u9fN-3rblA:
0.0		 3u9fM-3rblA:
18.50
3u9fN-3rblA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 12 CYH A 438
SER A 211
SER A 250
VAL A 445
VAL A 402
 None
 1.08A 3u9fP-3rblA:
undetectable
3u9fS-3rblA:
undetectable		 3u9fP-3rblA:
18.50
3u9fS-3rblA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 8 ARG A 397
ILE A 467
TRP A 464
GLU A 465
 None
 1.10A 4cx7A-3rblA:
undetectable
4cx7B-3rblA:
undetectable		 4cx7A-3rblA:
21.46
4cx7B-3rblA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 8 TRP A 464
GLU A 465
ARG A 397
ILE A 467
 None
 1.11A 4cx7A-3rblA:
undetectable
4cx7B-3rblA:
undetectable		 4cx7A-3rblA:
21.46
4cx7B-3rblA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 8 ARG A 397
ILE A 467
TRP A 464
GLU A 465
 None
 1.12A 4cx7C-3rblA:
undetectable
4cx7D-3rblA:
undetectable		 4cx7C-3rblA:
21.46
4cx7D-3rblA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		3 / 3 GLY A 276
SER A 277
TRP A 304
 None
 0.93A 4e7cD-3rblA:
undetectable		 4e7cD-3rblA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 12 SER A 108
CYH A 111
PHE A 357
ASP A  92
GLY A  96
 None
 1.34A 4j7xA-3rblA:
undetectable		 4j7xA-3rblA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 12 SER A 108
CYH A 111
PHE A 357
ASP A  92
GLY A  96
 None
 1.32A 4j7xF-3rblA:
undetectable		 4j7xF-3rblA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 12 ALA A 275
GLY A 407
LEU A 384
ALA A 278
TYR A 377
 None
 1.05A 4lg1A-3rblA:
undetectable		 4lg1A-3rblA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 8 ARG A 285
VAL A 240
VAL A 291
GLY A 290
 None
 1.00A 4mk4A-3rblA:
4.2		 4mk4A-3rblA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 7 ARG A 397
ILE A 467
TRP A 464
GLU A 465
 None
 1.21A 4nosC-3rblA:
undetectable
4nosD-3rblA:
undetectable		 4nosC-3rblA:
20.48
4nosD-3rblA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		3 / 3 PRO A  87
MET A  89
TYR A  86
 None
 0.77A 4qa2B-3rblA:
4.8		 4qa2B-3rblA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 12 ALA A 148
SER A 277
ARG A 285
LEU A 128
THR A 152
 None
 1.14A 4qi9A-3rblA:
2.5		 4qi9A-3rblA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 5 LEU A 128
PHE A 299
LEU A 288
TRP A 315
 None
 1.50A 5m10A-3rblA:
undetectable		 5m10A-3rblA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		5 / 12 LEU A 222
ALA A 216
SER A 250
LEU A 243
MET A 239
 None
 1.23A 5mwyA-3rblA:
undetectable		 5mwyA-3rblA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3rbl AROMATIC L-AMINO
ACID DECARBOXYLASE
(Homo
sapiens) 		4 / 4 GLY A 290
ARG A 285
ASN A 289
LEU A 254
 None
 1.30A 6b58A-3rblA:
undetectable		 6b58A-3rblA:
20.85