SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rby'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 3rby UNCHARACTERIZED
PROTEIN YLR301W
(Saccharomyces
cerevisiae) 		3 / 3 ALA A   3
VAL A 132
TRP A 175
 None
 0.92A 1gmkA-3rbyA:
undetectable
1gmkB-3rbyA:
undetectable		 1gmkA-3rbyA:
6.17
1gmkB-3rbyA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 3rby UNCHARACTERIZED
PROTEIN YLR301W
(Saccharomyces
cerevisiae) 		3 / 4 VAL A  71
TRP A 102
TRP A  99
 None
None
PGE  A 701 (-4.1A)
 1.24A 1gmkA-3rbyA:
undetectable
1gmkB-3rbyA:
undetectable		 1gmkA-3rbyA:
6.17
1gmkB-3rbyA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 3rby UNCHARACTERIZED
PROTEIN YLR301W
(Saccharomyces
cerevisiae) 		3 / 3 ALA A   3
VAL A 132
TRP A 175
 None
 1.00A 1gmkC-3rbyA:
undetectable
1gmkD-3rbyA:
undetectable		 1gmkC-3rbyA:
6.17
1gmkD-3rbyA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 3rby UNCHARACTERIZED
PROTEIN YLR301W
(Saccharomyces
cerevisiae) 		3 / 4 VAL A  71
TRP A 102
TRP A  99
 None
None
PGE  A 701 (-4.1A)
 1.29A 1gmkC-3rbyA:
undetectable
1gmkD-3rbyA:
undetectable		 1gmkC-3rbyA:
6.17
1gmkD-3rbyA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3rby UNCHARACTERIZED
PROTEIN YLR301W
(Saccharomyces
cerevisiae) 		5 / 12 SER A 232
THR A 231
ASN A 236
TRP A 237
VAL A 160
 None
 1.13A 2x2iA-3rbyA:
2.5		 2x2iA-3rbyA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3rby UNCHARACTERIZED
PROTEIN YLR301W
(Saccharomyces
cerevisiae) 		3 / 3 THR A  98
VAL A  70
GLU A 108
 None
 0.76A 3v4tA-3rbyA:
undetectable
3v4tD-3rbyA:
undetectable		 3v4tA-3rbyA:
19.86
3v4tD-3rbyA:
19.86