SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rc2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 3rc2 SUGAR
3-KETOREDUCTASE
(Actinomadura
kijaniata) 		5 / 12 ALA A  81
GLY A 178
GLY A 177
LEU A 232
LEU A 318
 NAP  A 336 ( 4.4A)
None
None
None
None
 0.93A 1eizA-3rc2A:
4.9		 1eizA-3rc2A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 3rc2 SUGAR
3-KETOREDUCTASE
(Actinomadura
kijaniata) 		4 / 6 PHE A 155
GLU A 245
LEU A 253
VAL A 140
 None
 1.07A 1hk1A-3rc2A:
undetectable		 1hk1A-3rc2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 3rc2 SUGAR
3-KETOREDUCTASE
(Actinomadura
kijaniata) 		4 / 8 LEU A 132
LEU A 104
SER A 312
GLU A 307
 None
 1.08A 1i7zA-3rc2A:
undetectable		 1i7zA-3rc2A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3rc2 SUGAR
3-KETOREDUCTASE
(Actinomadura
kijaniata) 		5 / 10 ALA A 298
ALA A 296
THR A  35
LEU A  29
VAL A  12
 None
 1.23A 2wuzA-3rc2A:
undetectable		 2wuzA-3rc2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3rc2 SUGAR
3-KETOREDUCTASE
(Actinomadura
kijaniata) 		5 / 10 ALA A 298
ALA A 296
THR A  35
LEU A  29
VAL A  12
 None
 1.24A 2wuzB-3rc2A:
undetectable		 2wuzB-3rc2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 3rc2 SUGAR
3-KETOREDUCTASE
(Actinomadura
kijaniata) 		5 / 12 LEU A  67
ALA A 100
ALA A 118
VAL A 117
ILE A  15
 None
 1.09A 3czhB-3rc2A:
undetectable		 3czhB-3rc2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3rc2 SUGAR
3-KETOREDUCTASE
(Actinomadura
kijaniata) 		5 / 9 LEU A  99
VAL A  14
ILE A  20
ALA A  21
ALA A  28
 None
None
NAP  A 336 (-3.8A)
None
None
 1.27A 3mdtA-3rc2A:
undetectable		 3mdtA-3rc2A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3rc2 SUGAR
3-KETOREDUCTASE
(Actinomadura
kijaniata) 		3 / 3 LEU A  79
PRO A  80
LEU A  83
 NAP  A 336 (-4.3A)
NAP  A 336 (-4.3A)
None
 0.43A 3w1wB-3rc2A:
3.9		 3w1wB-3rc2A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3rc2 SUGAR
3-KETOREDUCTASE
(Actinomadura
kijaniata) 		4 / 4 ALA A 316
VAL A 319
ASP A 320
LEU A 181
 None
 1.12A 4e7gA-3rc2A:
1.4		 4e7gA-3rc2A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3rc2 SUGAR
3-KETOREDUCTASE
(Actinomadura
kijaniata) 		4 / 5 GLN A 297
LEU A 300
SER A 301
ASP A 311
 None
 1.06A 4qtuD-3rc2A:
4.9		 4qtuD-3rc2A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 3rc2 SUGAR
3-KETOREDUCTASE
(Actinomadura
kijaniata) 		4 / 8 ILE A  10
ARG A  11
GLY A  13
THR A  38
 None
 0.93A 5hwaA-3rc2A:
undetectable		 5hwaA-3rc2A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3rc2 SUGAR
3-KETOREDUCTASE
(Actinomadura
kijaniata) 		3 / 3 THR A 106
PRO A 103
ASP A 182
 None
NAP  A 336 ( 4.8A)
NAP  A 336 (-3.5A)
 0.87A 5l8dB-3rc2A:
undetectable		 5l8dB-3rc2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3rc2 SUGAR
3-KETOREDUCTASE
(Actinomadura
kijaniata) 		3 / 3 THR A 106
PRO A 103
ASP A 182
 None
NAP  A 336 ( 4.8A)
NAP  A 336 (-3.5A)
 0.87A 5mwuB-3rc2A:
undetectable		 5mwuB-3rc2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3rc2 SUGAR
3-KETOREDUCTASE
(Actinomadura
kijaniata) 		5 / 12 LEU A 199
PHE A 155
PHE A 259
THR A 160
GLY A 235
 None
 1.24A 5xipA-3rc2A:
2.8		 5xipA-3rc2A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3rc2 SUGAR
3-KETOREDUCTASE
(Actinomadura
kijaniata) 		3 / 3 MET A 236
ASP A 182
ARG A  23
 None
NAP  A 336 (-3.5A)
TLO  A 335 ( 2.5A)
 1.22A 5z6kA-3rc2A:
undetectable		 5z6kA-3rc2A:
19.71