SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rc3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 373
ILE A 459
LEU A 498
VAL A 371
ILE A 438
 None
 1.04A 1epbB-3rc3A:
undetectable		 1epbB-3rc3A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLU A 482
LEU A 354
ARG A 365
LEU A 494
 None
 0.96A 1ereF-3rc3A:
undetectable		 1ereF-3rc3A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU A 235
GLU A 242
ALA A 237
LEU A 233
 None
 1.18A 1etb1-3rc3A:
undetectable		 1etb1-3rc3A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 THR A 209
GLU A 322
ASP A 503
 ANP  A 801 (-3.5A)
None
None
 0.86A 1nt2A-3rc3A:
undetectable		 1nt2A-3rc3A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 473
ARG A 470
ILE A 351
 ANP  A 801 (-3.0A)
ANP  A 801 (-3.0A)
None
 0.82A 1uobA-3rc3A:
undetectable		 1uobA-3rc3A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A  98
PHE A 124
ARG A 128
 None
 0.68A 2a3aA-3rc3A:
undetectable		 2a3aA-3rc3A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLU A 242
ALA A 237
LEU A 233
THR A 275
 None
 0.91A 2roxB-3rc3A:
undetectable		 2roxB-3rc3A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLY A 110
PHE A 120
PHE A 100
ILE A 106
 None
 0.88A 2y7wC-3rc3A:
undetectable		 2y7wC-3rc3A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 TYR A 229
ASP A 291
ILE A 218
PHE A 222
ARG A 473
 None
ANP  A 801 ( 4.0A)
None
None
ANP  A 801 (-3.0A)
 1.44A 3a8iD-3rc3A:
undetectable		 3a8iD-3rc3A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU A 235
ALA A 237
LEU A 233
THR A 275
 None
 0.95A 3cfqA-3rc3A:
undetectable		 3cfqA-3rc3A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ILE A 612
GLN A 592
ILE A 655
LEU A 591
 None
 1.27A 3dzyD-3rc3A:
undetectable		 3dzyD-3rc3A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ALA A 577
PHE A 593
ILE A 655
LEU A 608
VAL A 634
 None
 0.88A 3n0hA-3rc3A:
undetectable		 3n0hA-3rc3A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 577
PHE A 593
ILE A 655
LEU A 608
VAL A 634
 None
 0.83A 3s3vA-3rc3A:
undetectable		 3s3vA-3rc3A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 TYR A 572
HIS A 511
LEU A 185
TRP A 191
 None
 1.30A 3uzzB-3rc3A:
undetectable		 3uzzB-3rc3A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 235
ALA A 237
LEU A 233
THR A 275
 None
 0.91A 4ikjA-3rc3A:
undetectable
4ikjB-3rc3A:
undetectable		 4ikjA-3rc3A:
12.70
4ikjB-3rc3A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 290
ALA A 288
ILE A 202
ALA A 217
VAL A 329
 None
 1.00A 4k6iA-3rc3A:
undetectable		 4k6iA-3rc3A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 577
PHE A 593
ILE A 655
LEU A 608
VAL A 634
 None
 0.84A 4kfjB-3rc3A:
undetectable		 4kfjB-3rc3A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLY A 367
ASP A 416
PRO A 414
ARG A 477
 None
 1.25A 4lajA-3rc3A:
undetectable
4lajB-3rc3A:
undetectable		 4lajA-3rc3A:
19.07
4lajB-3rc3A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 259
GLU A 258
ARG A 644
 None
 0.85A 4mwvA-3rc3A:
undetectable		 4mwvA-3rc3A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LEU A 109
ASP A 112
TYR A 113
 None
 0.54A 4qc6B-3rc3A:
undetectable		 4qc6B-3rc3A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 655
PHE A 593
LEU A 608
PHE A 585
 None
 0.95A 4qopC-3rc3A:
undetectable		 4qopC-3rc3A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ALA A 217
ARG A 200
THR A 336
GLU A 338
 None
 0.88A 5bs8A-3rc3A:
undetectable
5bs8C-3rc3A:
undetectable
5bs8D-3rc3A:
2.4		 5bs8A-3rc3A:
22.36
5bs8C-3rc3A:
22.36
5bs8D-3rc3A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ALA A 217
ARG A 200
THR A 336
GLU A 338
 None
 0.87A 5btgA-3rc3A:
undetectable
5btgB-3rc3A:
2.4
5btgC-3rc3A:
undetectable		 5btgA-3rc3A:
22.36
5btgB-3rc3A:
16.42
5btgC-3rc3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ALA A 217
ARG A 200
THR A 336
GLU A 338
 None
 0.80A 5btgA-3rc3A:
undetectable
5btgC-3rc3A:
undetectable
5btgD-3rc3A:
2.4		 5btgA-3rc3A:
22.36
5btgC-3rc3A:
22.36
5btgD-3rc3A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A  69
HIS A 165
PHE A 170
LEU A 115
PRO A  66
 None
 1.34A 5hnxB-3rc3A:
undetectable		 5hnxB-3rc3A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ILE A 370
ILE A 435
MET A 486
 None
 0.72A 5i9yA-3rc3A:
undetectable		 5i9yA-3rc3A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LEU A 361
TYR A 441
SER A 380
 None
 0.84A 5iktA-3rc3A:
undetectable		 5iktA-3rc3A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PHE A 411
ARG A 473
ILE A 435
GLY A 472
 None
ANP  A 801 (-3.0A)
None
None
 0.97A 5nzxA-3rc3A:
3.6		 5nzxA-3rc3A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 630
LEU A 616
ILE A 665
ILE A 666
SER A 398
 None
 1.38A 5uanB-3rc3A:
undetectable		 5uanB-3rc3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 PRO A 401
GLY A 402
THR A 403
LYS A 409
 None
 0.41A 5xxiA-3rc3A:
undetectable		 5xxiA-3rc3A:
21.26