SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rcm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		5 / 12 ASP A   5
GLY A   7
ASP A 209
VAL A 235
GLY A 178
 None
None
CIT  A 289 (-3.3A)
None
None
 1.09A 1hsgB-3rcmA:
undetectable		 1hsgB-3rcmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		5 / 12 GLU A  97
HIS A  68
HIS A 133
ASP A 209
PRO A 211
 ZN  A 288 ( 2.3A)
CIT  A 289 (-4.0A)
ZN  A 288 ( 3.2A)
CIT  A 289 (-3.3A)
None
 1.38A 1ituA-3rcmA:
13.9		 1ituA-3rcmA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		5 / 12 GLU A  97
HIS A  68
HIS A 133
HIS A 158
PRO A 211
 ZN  A 288 ( 2.3A)
CIT  A 289 (-4.0A)
ZN  A 288 ( 3.2A)
ZN  A 288 ( 3.2A)
None
 1.36A 1ituA-3rcmA:
13.9		 1ituA-3rcmA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		5 / 12 GLU A  97
HIS A  68
HIS A 133
ASP A 209
PRO A 211
 ZN  A 288 ( 2.3A)
CIT  A 289 (-4.0A)
ZN  A 288 ( 3.2A)
CIT  A 289 (-3.3A)
None
 1.39A 1ituB-3rcmA:
13.6		 1ituB-3rcmA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		5 / 12 GLU A  97
HIS A  68
HIS A 133
HIS A 158
PRO A 211
 ZN  A 288 ( 2.3A)
CIT  A 289 (-4.0A)
ZN  A 288 ( 3.2A)
ZN  A 288 ( 3.2A)
None
 1.39A 1ituB-3rcmA:
13.6		 1ituB-3rcmA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		4 / 4 HIS A 133
GLU A  97
HIS A  68
HIS A  70
 ZN  A 288 ( 3.2A)
ZN  A 288 ( 2.3A)
CIT  A 289 (-4.0A)
ACT  A 290 ( 4.5A)
 1.29A 1uttA-3rcmA:
undetectable		 1uttA-3rcmA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		5 / 11 PRO A 220
GLU A 228
ILE A  22
ALA A 230
PRO A 283
 None
 0.94A 2admA-3rcmA:
undetectable		 2admA-3rcmA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		5 / 11 PRO A 220
GLU A 228
ILE A  22
ALA A 230
PRO A 283
 None
 0.93A 2admB-3rcmA:
undetectable		 2admB-3rcmA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		5 / 12 ASP A   5
GLY A   7
ASP A 209
VAL A 235
GLY A 178
 None
None
CIT  A 289 (-3.3A)
None
None
 1.08A 2avsB-3rcmA:
undetectable		 2avsB-3rcmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		5 / 9 GLU A 286
LEU A  54
LEU A  10
ALA A 230
ALA A  21
 None
 1.43A 2bxcB-3rcmA:
undetectable		 2bxcB-3rcmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		5 / 12 LEU A 116
GLU A 113
ALA A 143
LEU A 142
LEU A 100
 None
 1.10A 2c12C-3rcmA:
undetectable		 2c12C-3rcmA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		4 / 4 HIS A 133
GLU A  97
HIS A  68
HIS A  70
 ZN  A 288 ( 3.2A)
ZN  A 288 ( 2.3A)
CIT  A 289 (-4.0A)
ACT  A 290 ( 4.5A)
 1.34A 2ozrE-3rcmA:
undetectable		 2ozrE-3rcmA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		5 / 12 ASP A   5
GLY A   7
ASP A 209
VAL A 235
GLY A 178
 None
None
CIT  A 289 (-3.3A)
None
None
 1.07A 2z54A-3rcmA:
undetectable		 2z54A-3rcmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		5 / 12 ASP A   5
GLY A   7
ASP A 209
VAL A 235
GLY A 178
 None
None
CIT  A 289 (-3.3A)
None
None
 1.08A 3d1zB-3rcmA:
undetectable		 3d1zB-3rcmA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		4 / 6 GLN A  46
LEU A  48
GLU A  45
LEU A  86
 None
 0.85A 3h5gA-3rcmA:
undetectable
3h5gC-3rcmA:
undetectable		 3h5gA-3rcmA:
7.97
3h5gC-3rcmA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		5 / 12 PHE A 131
HIS A 133
GLY A  38
LEU A  36
ASP A 209
 None
ZN  A 288 ( 3.2A)
None
None
CIT  A 289 (-3.3A)
 1.21A 3i5uA-3rcmA:
undetectable		 3i5uA-3rcmA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		5 / 9 ASP A   5
GLY A   7
ASP A 209
GLY A 178
LEU A 232
 None
None
CIT  A 289 (-3.3A)
None
None
 1.03A 3ogpB-3rcmA:
undetectable		 3ogpB-3rcmA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		5 / 12 LEU A 232
SER A 246
LEU A   3
THR A 254
THR A 250
 None
 1.44A 3thrA-3rcmA:
undetectable
3thrB-3rcmA:
undetectable
3thrC-3rcmA:
undetectable
3thrD-3rcmA:
1.2		 3thrA-3rcmA:
22.36
3thrB-3rcmA:
22.36
3thrC-3rcmA:
22.36
3thrD-3rcmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		5 / 12 ARG A 135
HIS A 133
ALA A 166
HIS A 158
ASP A 209
 CIT  A 289 (-4.0A)
ZN  A 288 ( 3.2A)
None
ZN  A 288 ( 3.2A)
CIT  A 289 (-3.3A)
 1.17A 4aqlA-3rcmA:
15.3		 4aqlA-3rcmA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		4 / 5 PHE A 131
ILE A   6
GLY A   7
THR A  37
 None
 0.81A 4ejjC-3rcmA:
undetectable		 4ejjC-3rcmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		4 / 6 GLN A  33
PHE A  62
ILE A   4
PHE A 262
 None
 1.14A 4fgkA-3rcmA:
undetectable		 4fgkA-3rcmA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		3 / 3 ASP A 209
GLY A   7
ASP A   5
 CIT  A 289 (-3.3A)
None
None
 0.64A 4xdtA-3rcmA:
undetectable		 4xdtA-3rcmA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3rcm TATD FAMILY
HYDROLASE
(Pseudomonas
putida) 		4 / 6 HIS A 158
ASP A 101
HIS A  70
HIS A  68
 ZN  A 288 ( 3.2A)
None
ACT  A 290 ( 4.5A)
CIT  A 289 (-4.0A)
 0.95A 5nelB-3rcmA:
3.3
5nelC-3rcmA:
4.1		 5nelB-3rcmA:
19.40
5nelC-3rcmA:
19.40