SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rcy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 8 ALA A 257
ALA A 308
GLU A 335
LEU A 262
 None
None
None
RIB  A 433 (-4.7A)
 0.69A 2bxgA-3rcyA:
undetectable		 2bxgA-3rcyA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 8 TYR A  41
TYR A 128
HIS A 210
GLY A 208
 None
None
MG  A 500 ( 4.9A)
None
 1.06A 2ha4A-3rcyA:
undetectable		 2ha4A-3rcyA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 7 TYR A  41
TYR A 128
HIS A 210
GLY A 208
 None
None
MG  A 500 ( 4.9A)
None
 1.06A 2ha4B-3rcyA:
undetectable		 2ha4B-3rcyA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 7 TYR A 172
TYR A 132
GLU A 335
HIS A 310
 None
 1.22A 2ha4B-3rcyA:
undetectable		 2ha4B-3rcyA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_2
(NEURAMINIDASE)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 4 ASP A 370
TRP A  37
ILE A   9
ARG A 375
 None
 1.28A 2htqA-3rcyA:
undetectable		 2htqA-3rcyA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 12 ARG A 111
PHE A 324
ALA A 115
ILE A 328
ASN A 122
 None
 1.17A 2rlcA-3rcyA:
undetectable		 2rlcA-3rcyA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 6 ALA A 372
ALA A 374
THR A  11
PHE A 341
 None
 0.89A 2xfhA-3rcyA:
undetectable		 2xfhA-3rcyA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 8 GLU A 234
TYR A 172
GLU A 260
ILE A 225
 MG  A 500 (-3.0A)
None
MG  A 500 (-2.6A)
None
 0.80A 3jz0B-3rcyA:
undetectable		 3jz0B-3rcyA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		6 / 10 ALA A  93
VAL A  77
ILE A  91
GLY A 289
ILE A  99
VAL A  57
 None
 1.49A 3t3cB-3rcyA:
undetectable		 3t3cB-3rcyA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 11 HIS A 210
GLU A 260
HIS A 310
GLU A 335
TYR A 130
 MG  A 500 ( 4.9A)
MG  A 500 (-2.6A)
None
None
None
 1.45A 4c2pA-3rcyA:
undetectable		 4c2pA-3rcyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 11 GLY A  17
TRP A 143
TYR A 130
HIS A 342
GLY A 314
 None
 1.27A 4ey7A-3rcyA:
2.0		 4ey7A-3rcyA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 11 GLY A  17
TRP A 143
TYR A 130
HIS A 342
GLY A 314
 None
 1.26A 4ey7B-3rcyA:
undetectable		 4ey7B-3rcyA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 12 SER A 336
ALA A 283
GLU A 260
ALA A 313
TYR A  41
 None
None
MG  A 500 (-2.6A)
None
None
 1.39A 4ymgA-3rcyA:
undetectable		 4ymgA-3rcyA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 6 GLU A  48
GLY A 285
ARG A 286
GLY A  92
 None
 0.78A 5cdnA-3rcyA:
undetectable
5cdnB-3rcyA:
undetectable		 5cdnA-3rcyA:
21.73
5cdnB-3rcyA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 11 ARG A 286
GLU A 387
TYR A  22
GLY A  46
GLY A 383
 None
 1.33A 5e3iB-3rcyA:
undetectable		 5e3iB-3rcyA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 8 ILE A  34
GLY A  33
CYH A 101
ASP A   5
 None
 0.92A 5hieD-3rcyA:
undetectable		 5hieD-3rcyA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 6 GLU A 260
ARG A 261
LEU A 262
ARG A 286
 MG  A 500 (-2.6A)
None
RIB  A 433 (-4.7A)
None
 1.15A 5l6eA-3rcyA:
undetectable
5l6eB-3rcyA:
undetectable		 5l6eA-3rcyA:
20.24
5l6eB-3rcyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 11 GLY A 285
GLU A  98
GLY A  96
LEU A  88
GLU A 292
 None
 0.91A 5o96G-3rcyA:
undetectable		 5o96G-3rcyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		3 / 3 LEU A 221
ILE A 185
TYR A 395
 None
 0.60A 5uunB-3rcyA:
undetectable		 5uunB-3rcyA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 10 VAL A 157
GLY A 160
GLY A 355
LEU A 205
ALA A 203
 None
 1.01A 5vm8B-3rcyA:
undetectable		 5vm8B-3rcyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 8 PHE A  94
ILE A  91
PHE A  74
THR A  83
 None
 1.08A 5x23A-3rcyA:
undetectable		 5x23A-3rcyA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 4 GLY A  38
LEU A  25
VAL A 316
GLU A  39
 None
 1.39A 5yw0A-3rcyA:
undetectable		 5yw0A-3rcyA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 8 ARG A 159
THR A 339
PRO A 340
PRO A  16
 None
 1.12A 6a4iA-3rcyA:
undetectable		 6a4iA-3rcyA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 7 ARG A 159
THR A 339
PRO A 340
PRO A  16
 None
 1.15A 6a4iB-3rcyA:
undetectable		 6a4iB-3rcyA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 9 ILE A  91
PHE A  74
SER A  79
SER A  80
THR A 263
 None
 1.31A 6awpA-3rcyA:
undetectable		 6awpA-3rcyA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 12 MET A  50
ILE A  54
VAL A  10
LEU A  97
LEU A  28
 None
 1.19A 6b54A-3rcyA:
undetectable		 6b54A-3rcyA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		5 / 10 GLY A 288
GLY A 289
ILE A  91
ALA A 287
GLY A  92
 None
 0.97A 6e5zA-3rcyA:
undetectable		 6e5zA-3rcyA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		3 / 3 TRP A 232
GLU A 235
GLU A 335
 None
 0.97A 6fhwA-3rcyA:
undetectable		 6fhwA-3rcyA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 3rcy MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Roseovarius
sp.
TM1035) 		4 / 6 PRO A  13
TRP A  23
ILE A 337
GLY A  17
 None
 0.90A 6gqiA-3rcyA:
undetectable		 6gqiA-3rcyA:
23.67