SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rd7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		6 / 12 ALA A  43
ALA A  41
LEU A 180
PHE A 101
MET A  61
LEU A 203
 None
 1.49A 1qabF-3rd7A:
undetectable		 1qabF-3rd7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		4 / 8 PHE A 247
SER A 248
THR A 274
THR A 259
 None
 0.75A 1sbrA-3rd7A:
undetectable		 1sbrA-3rd7A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		4 / 7 PHE A 247
SER A 248
THR A 274
THR A 259
 None
 0.78A 1sbrB-3rd7A:
undetectable		 1sbrB-3rd7A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		4 / 6 ARG A 177
GLU A 207
PRO A 162
ALA A 165
 None
 1.01A 2ejfB-3rd7A:
undetectable		 2ejfB-3rd7A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		4 / 7 ARG A 177
GLU A 207
PRO A 162
ALA A 165
 None
 1.14A 2ejgA-3rd7A:
undetectable		 2ejgA-3rd7A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		4 / 6 PHE A 107
GLY A  48
THR A  50
ARG A  89
 None
 0.97A 2f7fA-3rd7A:
undetectable		 2f7fA-3rd7A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		4 / 6 LEU A 205
THR A 204
PHE A 244
LEU A 200
 None
 0.95A 2wm3A-3rd7A:
undetectable		 2wm3A-3rd7A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		4 / 5 VAL A  99
VAL A  98
GLN A  71
PHE A  63
 None
 1.23A 3bjwH-3rd7A:
undetectable		 3bjwH-3rd7A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		4 / 6 VAL A  99
VAL A  98
GLN A  71
PHE A  63
 None
 1.19A 3bjwF-3rd7A:
undetectable		 3bjwF-3rd7A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		5 / 12 ALA A 236
LEU A 242
LEU A 200
VAL A 196
LEU A   5
 None
 1.12A 3fl9B-3rd7A:
undetectable		 3fl9B-3rd7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		5 / 10 ALA A 236
LEU A 242
LEU A 200
VAL A 196
LEU A   5
 None
 1.09A 3fl9E-3rd7A:
undetectable		 3fl9E-3rd7A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		5 / 12 LEU A 242
LEU A 180
ARG A 181
PHE A 153
LEU A   5
 None
 1.34A 3gwuA-3rd7A:
undetectable		 3gwuA-3rd7A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		5 / 12 LEU A 191
CYH A 195
LEU A  14
GLY A  24
THR A  25
 None
 1.25A 3okxA-3rd7A:
undetectable		 3okxA-3rd7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		5 / 12 LEU A 191
CYH A 195
TYR A  75
LEU A  14
GLY A  24
 None
 1.32A 3okxA-3rd7A:
undetectable		 3okxA-3rd7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		5 / 12 LEU A 191
CYH A 195
LEU A  14
GLY A  24
THR A  25
 None
 1.24A 3okxB-3rd7A:
undetectable		 3okxB-3rd7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		5 / 12 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
 None
 1.07A 4j6dA-3rd7A:
undetectable		 4j6dA-3rd7A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		5 / 12 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
 None
 1.09A 4j6dB-3rd7A:
undetectable		 4j6dB-3rd7A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		5 / 11 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
 None
 1.09A 4jbtB-3rd7A:
undetectable		 4jbtB-3rd7A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		5 / 12 PHE A  63
GLY A  67
ILE A  35
SER A  37
GLN A 275
 None
 1.29A 4rtpA-3rd7A:
undetectable		 4rtpA-3rd7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3rd7 ACYL-COA
THIOESTERASE
(Mycobacterium
avium) 		3 / 3 VAL A 129
SER A 127
TRP A 179
 None
 0.98A 5jwaA-3rd7A:
undetectable		 5jwaA-3rd7A:
16.28