SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rd8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		3 / 3 THR A 143
THR A 145
PRO A 142
 None
 0.83A 1dscC-3rd8A:
undetectable		 1dscC-3rd8A:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASN A 366
PHE A  98
GLY A 101
SER A 102
THR A 104
 None
 1.36A 1g60A-3rd8A:
undetectable		 1g60A-3rd8A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 9 GLY A  53
GLY A  82
GLY A  87
ASP A  90
ARG A  46
 None
 1.20A 1mxdA-3rd8A:
undetectable		 1mxdA-3rd8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 4 SER A 375
VAL A 334
PHE A 371
VAL A 212
 None
 1.40A 1o86A-3rd8A:
3.2		 1o86A-3rd8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		3 / 3 SER A 298
GLY A 297
ARG A 183
 None
 0.59A 1t9wA-3rd8A:
undetectable		 1t9wA-3rd8A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		3 / 3 THR A 143
THR A 145
PRO A 142
 None
 0.84A 1unjW-3rd8A:
undetectable		 1unjW-3rd8A:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		3 / 3 THR A 143
THR A 145
PRO A 142
 None
 0.85A 1unjX-3rd8A:
undetectable		 1unjX-3rd8A:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		3 / 3 THR A 145
PRO A 142
THR A 143
 None
 0.87A 1unmE-3rd8A:
undetectable		 1unmE-3rd8A:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		3 / 3 THR A 143
THR A 145
PRO A 142
 None
 0.84A 1unmE-3rd8A:
undetectable		 1unmE-3rd8A:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		3 / 3 THR A 143
THR A 145
PRO A 142
 None
 0.86A 1unmF-3rd8A:
undetectable		 1unmF-3rd8A:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ILE A 147
LEU A 368
ALA A 152
GLU A 151
 None
 1.26A 1xvaA-3rd8A:
undetectable
1xvaB-3rd8A:
undetectable		 1xvaA-3rd8A:
22.53
1xvaB-3rd8A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASN A 132
ASN A 111
ILE A  84
THR A 140
 None
 1.17A 2hkkA-3rd8A:
undetectable		 2hkkA-3rd8A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ALA A 335
LEU A 374
VAL A 377
ILE A 205
LEU A 164
 None
 1.37A 3fl9H-3rd8A:
undetectable		 3fl9H-3rd8A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 7 PHE A 371
ARG A 269
LEU A 256
THR A  47
 None
 0.88A 3nxuA-3rd8A:
undetectable		 3nxuA-3rd8A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ILE A 147
ALA A 259
LEU A 222
LEU A  55
ALA A  51
 None
 0.94A 3ozvB-3rd8A:
undetectable		 3ozvB-3rd8A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 360
SER A 102
GLY A 101
SER A 105
THR A 104
 None
 1.17A 3r75A-3rd8A:
undetectable		 3r75A-3rd8A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 360
SER A 102
GLY A 101
SER A 105
THR A 104
 None
 1.19A 3r75B-3rd8A:
undetectable		 3r75B-3rd8A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 7 PHE A 141
ALA A  51
THR A  47
LEU A 368
 None
 0.88A 3t3sC-3rd8A:
0.6		 3t3sC-3rd8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB802_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A 239
SER A 262
SER A 136
CYH A  59
PRO A 236
 None
 1.37A 3v8vB-3rd8A:
0.0		 3v8vB-3rd8A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ALA A 254
GLY A 252
LEU A 256
ASN A 249
ILE A 147
 None
 1.15A 3wdmB-3rd8A:
undetectable		 3wdmB-3rd8A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 389
SER A 167
PHE A 198
ARG A 294
PRO A 328
 None
 1.49A 4b3aA-3rd8A:
undetectable		 4b3aA-3rd8A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 6 PHE A 141
ALA A  51
THR A  47
LEU A 368
 None
 0.90A 4ejgD-3rd8A:
0.1		 4ejgD-3rd8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 289
ALA A 169
ILE A 307
LEU A 389
ILE A 293
 None
 0.95A 4kjjA-3rd8A:
undetectable		 4kjjA-3rd8A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ALA A 382
ASP A 292
ILE A 293
ILE A 307
 None
 0.85A 4kttD-3rd8A:
undetectable		 4kttD-3rd8A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLY A 230
GLY A 226
GLY A 225
ALA A 228
GLN A 135
 None
 1.17A 4l8fB-3rd8A:
undetectable		 4l8fB-3rd8A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 10 LEU A 286
LEU A 164
ILE A 386
LEU A 168
LEU A 309
 None
 1.04A 4odoA-3rd8A:
undetectable		 4odoA-3rd8A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASN A 132
VAL A 131
LEU A 247
ALA A  60
GLY A 225
 None
 1.28A 4qckA-3rd8A:
undetectable		 4qckA-3rd8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 9 THR A 110
THR A 140
ILE A  49
GLY A  53
ALA A  51
 None
 0.95A 4qvqK-3rd8A:
undetectable
4qvqL-3rd8A:
undetectable		 4qvqK-3rd8A:
20.23
4qvqL-3rd8A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 9 THR A 110
THR A 140
ILE A  49
GLY A  53
ALA A  51
 None
 0.95A 4qvqY-3rd8A:
undetectable
4qvqZ-3rd8A:
undetectable		 4qvqY-3rd8A:
20.23
4qvqZ-3rd8A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 6 VAL A 123
LEU A  69
ILE A  77
ALA A  76
 None
 0.73A 4zf8A-3rd8A:
0.3		 4zf8A-3rd8A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A  60
VAL A 246
GLU A 250
LEU A 247
LEU A  54
 None
 0.90A 4zmeA-3rd8A:
undetectable		 4zmeA-3rd8A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ALA A  60
VAL A 246
GLU A 250
LEU A 247
LEU A  54
 None
 0.90A 4zmeB-3rd8A:
undetectable		 4zmeB-3rd8A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLU A 369
THR A 372
THR A 145
LEU A  44
 None
 1.26A 5axaA-3rd8A:
undetectable		 5axaA-3rd8A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLU A 369
THR A 372
THR A 145
LEU A  44
 None
 1.29A 5axaC-3rd8A:
undetectable		 5axaC-3rd8A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLU A 264
LEU A  52
ALA A 223
THR A 104
LEU A 356
 None
 1.34A 5mm4B-3rd8A:
undetectable		 5mm4B-3rd8A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLU A 306
ALA A 400
THR A 408
ARG A 463
ARG A 183
 None
 1.24A 5nd3B-3rd8A:
undetectable		 5nd3B-3rd8A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLY A 220
LEU A 219
HIS A 146
 None
 0.68A 5u63A-3rd8A:
undetectable		 5u63A-3rd8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLY A 220
LEU A 219
HIS A 146
 None
 0.66A 5u63B-3rd8A:
undetectable		 5u63B-3rd8A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 4 GLU A 369
THR A 372
THR A 145
LEU A  44
 None
 1.26A 5v96A-3rd8A:
undetectable		 5v96A-3rd8A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 4 GLU A 369
THR A 372
THR A 145
LEU A  44
 None
 1.27A 5v96B-3rd8A:
undetectable		 5v96B-3rd8A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 4 GLU A 369
THR A 372
THR A 145
LEU A  44
 None
 1.26A 5v96C-3rd8A:
undetectable		 5v96C-3rd8A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 4 GLU A 369
THR A 372
THR A 145
LEU A  44
 None
 1.25A 5v96D-3rd8A:
undetectable		 5v96D-3rd8A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 10 LEU A 164
GLY A 208
ILE A 282
PHE A 381
ILE A 289
 None
 1.23A 6ebpB-3rd8A:
4.5		 6ebpB-3rd8A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		5 / 10 LEU A 164
GLY A 208
ILE A 282
PHE A 381
ILE A 289
 None
 1.18A 6ebpC-3rd8A:
2.2		 6ebpC-3rd8A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASP A  90
ILE A  84
ARG A  46
ASN A 111
 None
 1.02A 6hisA-3rd8A:
2.2
6hisB-3rd8A:
2.2		 6hisA-3rd8A:
10.13
6hisB-3rd8A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASP A  90
ILE A  84
ARG A  46
ASN A 111
 None
 1.03A 6hisB-3rd8A:
2.2
6hisC-3rd8A:
2.2		 6hisB-3rd8A:
10.13
6hisC-3rd8A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASP A  90
ILE A  84
ARG A  46
ASN A 111
 None
 1.03A 6hisC-3rd8A:
2.2
6hisD-3rd8A:
2.1		 6hisC-3rd8A:
10.13
6hisD-3rd8A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASP A  90
ILE A  84
ARG A  46
ASN A 111
 None
 1.01A 6hisD-3rd8A:
2.1
6hisE-3rd8A:
2.2		 6hisD-3rd8A:
10.13
6hisE-3rd8A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3rd8 FUMARATE HYDRATASE
CLASS II
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASN A 111
ASP A  90
ILE A  84
ARG A  46
 None
 1.03A 6hisA-3rd8A:
2.2
6hisE-3rd8A:
2.2		 6hisA-3rd8A:
10.13
6hisE-3rd8A:
10.13