SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ren'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 3ren GLYCOSYL HYDROLASE,
FAMILY 8
(Clostridium
perfringens) 		5 / 12 ASP A 196
ARG A 139
ILE A 141
ILE A 163
THR A 199
 None
 1.28A 1kijB-3renA:
undetectable		 1kijB-3renA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ren GLYCOSYL HYDROLASE,
FAMILY 8
(Clostridium
perfringens) 		5 / 12 ALA A 362
LEU A  88
PHE A 357
THR A 256
ILE A 257
 None
 1.13A 1re7A-3renA:
undetectable		 1re7A-3renA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3ren GLYCOSYL HYDROLASE,
FAMILY 8
(Clostridium
perfringens) 		5 / 10 THR A 298
PHE A 252
SER A 255
VAL A 230
GLY A 295
 None
 1.43A 2x2iD-3renA:
undetectable		 2x2iD-3renA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 3ren GLYCOSYL HYDROLASE,
FAMILY 8
(Clostridium
perfringens) 		4 / 5 TYR A 159
GLU A 111
ARG A 113
ASP A 107
 None
 1.24A 2yqzA-3renA:
undetectable		 2yqzA-3renA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 3ren GLYCOSYL HYDROLASE,
FAMILY 8
(Clostridium
perfringens) 		4 / 5 TYR A 159
GLU A 111
ARG A 113
ASP A 107
 None
 1.23A 2yqzB-3renA:
undetectable		 2yqzB-3renA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 3ren GLYCOSYL HYDROLASE,
FAMILY 8
(Clostridium
perfringens) 		5 / 11 GLY A 117
ILE A 119
SER A 120
PRO A 130
SER A 131
 None
None
None
SO4  A   2 ( 4.9A)
SO4  A   2 ( 3.9A)
 1.28A 3bjwB-3renA:
undetectable		 3bjwB-3renA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 3ren GLYCOSYL HYDROLASE,
FAMILY 8
(Clostridium
perfringens) 		5 / 11 GLY A 117
ILE A 119
SER A 120
PRO A 130
SER A 131
 None
None
None
SO4  A   2 ( 4.9A)
SO4  A   2 ( 3.9A)
 1.24A 3bjwH-3renA:
undetectable		 3bjwH-3renA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3ren GLYCOSYL HYDROLASE,
FAMILY 8
(Clostridium
perfringens) 		4 / 8 ALA A 326
ILE A 313
ASP A 319
ILE A 317
 None
 0.89A 4kttB-3renA:
undetectable		 4kttB-3renA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ren GLYCOSYL HYDROLASE,
FAMILY 8
(Clostridium
perfringens) 		5 / 12 ALA A 362
LEU A  88
PHE A 357
THR A 256
ILE A 257
 None
 1.13A 4nx6A-3renA:
undetectable		 4nx6A-3renA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ren GLYCOSYL HYDROLASE,
FAMILY 8
(Clostridium
perfringens) 		5 / 12 ALA A 362
LEU A  88
PHE A 357
THR A 256
ILE A 257
 None
 1.14A 4ptjA-3renA:
undetectable		 4ptjA-3renA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ren GLYCOSYL HYDROLASE,
FAMILY 8
(Clostridium
perfringens) 		5 / 12 ALA A 362
LEU A  88
PHE A 357
THR A 256
ILE A 257
 None
 1.14A 4x5fA-3renA:
undetectable		 4x5fA-3renA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 3ren GLYCOSYL HYDROLASE,
FAMILY 8
(Clostridium
perfringens) 		3 / 3 ASP A 103
SER A 153
TYR A 156
 None
 0.81A 5glmA-3renA:
undetectable		 5glmA-3renA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 3ren GLYCOSYL HYDROLASE,
FAMILY 8
(Clostridium
perfringens) 		5 / 12 GLY A 185
LYS A 186
ASN A 183
LEU A 114
LEU A 118
 None
 1.23A 5nwvA-3renA:
undetectable		 5nwvA-3renA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3ren GLYCOSYL HYDROLASE,
FAMILY 8
(Clostridium
perfringens) 		5 / 12 LEU A 312
ILE A 327
PHE A 280
LEU A 363
TYR A  92
 None
None
None
None
EDO  A 373 (-4.8A)
 1.22A 6djzA-3renA:
undetectable		 6djzA-3renA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3ren GLYCOSYL HYDROLASE,
FAMILY 8
(Clostridium
perfringens) 		4 / 7 ALA A 326
ILE A 313
ASP A 319
ILE A 317
 None
 0.88A 6fbnA-3renA:
undetectable		 6fbnA-3renA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 3ren GLYCOSYL HYDROLASE,
FAMILY 8
(Clostridium
perfringens) 		5 / 9 ILE A 276
ILE A 273
GLU A 302
VAL A 310
ILE A 313
 None
 1.46A 6hloA-3renA:
undetectable		 6hloA-3renA:
19.39