SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rf0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA2_0
(ACTINOMYCIN D)		 3rf0 EXOPOLYPHOSPHATASE
(Yersinia
pestis) 		4 / 4 THR A 146
PRO A 148
THR A 147
PRO A 165
 None
 1.34A 1a7yA-3rf0A:
undetectable
1a7yC-3rf0A:
undetectable		 1a7yA-3rf0A:
14.00
1a7yC-3rf0A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 3rf0 EXOPOLYPHOSPHATASE
(Yersinia
pestis) 		3 / 3 THR A 146
PRO A 148
THR A 147
 None
 0.87A 1a7yB-3rf0A:
undetectable		 1a7yB-3rf0A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3rf0 EXOPOLYPHOSPHATASE
(Yersinia
pestis) 		5 / 12 ALA A  12
HIS A  63
LEU A  62
LEU A  98
THR A  11
 None
 1.10A 1bzfA-3rf0A:
undetectable		 1bzfA-3rf0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 3rf0 EXOPOLYPHOSPHATASE
(Yersinia
pestis) 		4 / 5 LEU A 132
LEU A  62
MET A  74
THR A  32
 None
 1.40A 2oaxD-3rf0A:
3.2		 2oaxD-3rf0A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 3rf0 EXOPOLYPHOSPHATASE
(Yersinia
pestis) 		5 / 9 ASP A 178
LEU A 138
THR A  32
HIS A  63
LEU A 134
 None
 1.15A 3hy7A-3rf0A:
undetectable		 3hy7A-3rf0A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 3rf0 EXOPOLYPHOSPHATASE
(Yersinia
pestis) 		4 / 5 LEU A  55
LEU A  98
GLN A  49
TYR A 124
 None
None
NO3  A 212 (-3.6A)
NO3  A 212 (-4.0A)
 1.27A 5uc3A-3rf0A:
3.2		 5uc3A-3rf0A:
17.34