SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rf5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3rf5 MACROPHAGE MIGRATION
INHIBITORY FACTOR
(Ancylostoma
ceylanicum) 		3 / 3 ASP A  71
ASP A 100
ASN A  31
 None
 0.72A 2bm9D-3rf5A:
undetectable		 2bm9D-3rf5A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3rf5 MACROPHAGE MIGRATION
INHIBITORY FACTOR
(Ancylostoma
ceylanicum) 		9 / 11 PRO A   1
MET A   2
LYS A  32
ARG A  36
SER A  63
ILE A  64
VAL A 106
PHE A 108
VAL A 113
 FUZ  A 202 (-3.7A)
FUZ  A 202 (-3.4A)
FUZ  A 202 (-2.7A)
None
FUZ  A 202 (-3.5A)
FUZ  A 202 (-3.8A)
None
FUZ  A 202 (-3.6A)
FUZ  A 202 (-4.6A)
 0.15A 3rf4A-3rf5A:
24.0
3rf4C-3rf5A:
23.7		 3rf4A-3rf5A:
100.00
3rf4C-3rf5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3rf5 MACROPHAGE MIGRATION
INHIBITORY FACTOR
(Ancylostoma
ceylanicum) 		9 / 11 PRO A   1
MET A   2
LYS A  32
ARG A  36
SER A  63
ILE A  64
VAL A 106
PHE A 108
VAL A 113
 FUZ  A 202 (-3.7A)
FUZ  A 202 (-3.4A)
FUZ  A 202 (-2.7A)
None
FUZ  A 202 (-3.5A)
FUZ  A 202 (-3.8A)
None
FUZ  A 202 (-3.6A)
FUZ  A 202 (-4.6A)
 0.18A 3rf4A-3rf5A:
24.0
3rf4B-3rf5A:
23.8		 3rf4A-3rf5A:
100.00
3rf4B-3rf5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3rf5 MACROPHAGE MIGRATION
INHIBITORY FACTOR
(Ancylostoma
ceylanicum) 		9 / 11 PRO A   1
MET A   2
LYS A  32
ARG A  36
SER A  63
ILE A  64
VAL A 106
PHE A 108
VAL A 113
 FUZ  A 202 (-3.7A)
FUZ  A 202 (-3.4A)
FUZ  A 202 (-2.7A)
None
FUZ  A 202 (-3.5A)
FUZ  A 202 (-3.8A)
None
FUZ  A 202 (-3.6A)
FUZ  A 202 (-4.6A)
 0.19A 3rf4B-3rf5A:
23.8
3rf4C-3rf5A:
23.7		 3rf4B-3rf5A:
100.00
3rf4C-3rf5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3rf5 MACROPHAGE MIGRATION
INHIBITORY FACTOR
(Ancylostoma
ceylanicum) 		4 / 8 VAL A  61
TYR A  98
ILE A  37
LEU A  25
 None
 0.70A 4jq1B-3rf5A:
undetectable		 4jq1B-3rf5A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3rf5 MACROPHAGE MIGRATION
INHIBITORY FACTOR
(Ancylostoma
ceylanicum) 		4 / 7 GLU A  62
ILE A  39
LEU A  87
ILE A  59
 None
 0.87A 4xumA-3rf5A:
undetectable		 4xumA-3rf5A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		 3rf5 MACROPHAGE MIGRATION
INHIBITORY FACTOR
(Ancylostoma
ceylanicum) 		5 / 12 ASN A  17
VAL A  41
VAL A   5
LEU A  87
THR A  86
 None
 1.15A 5jnaA-3rf5A:
undetectable		 5jnaA-3rf5A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3rf5 MACROPHAGE MIGRATION
INHIBITORY FACTOR
(Ancylostoma
ceylanicum) 		5 / 12 PRO A  10
GLY A  44
LYS A  88
ASP A  85
PRO A  15
 None
 1.24A 5zvgA-3rf5A:
undetectable		 5zvgA-3rf5A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3rf5 MACROPHAGE MIGRATION
INHIBITORY FACTOR
(Ancylostoma
ceylanicum) 		5 / 12 PRO A  10
GLY A  44
LYS A  88
ASP A  85
PRO A  15
 None
 1.26A 5zvgB-3rf5A:
undetectable		 5zvgB-3rf5A:
14.40