SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rf7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		4 / 8 ASP A 104
GLY A 273
THR A 191
GLY A 145
 NAD  A 358 (-2.7A)
None
NAD  A 358 (-3.0A)
None
 0.68A 1jr1B-3rf7A:
undetectable		 1jr1B-3rf7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		3 / 3 THR A 206
GLU A 201
ASP A 194
 None
None
FE  A 360 (-2.0A)
 0.83A 1nt2A-3rf7A:
undetectable		 1nt2A-3rf7A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		4 / 5 THR A  72
SER A 119
PRO A 157
SER A 118
 None
None
None
PEG  A 368 ( 4.5A)
 1.26A 2hdnA-3rf7A:
undetectable
2hdnB-3rf7A:
undetectable
2hdnD-3rf7A:
undetectable		 2hdnA-3rf7A:
9.19
2hdnB-3rf7A:
21.05
2hdnD-3rf7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		4 / 5 SER A 118
THR A  72
SER A 119
PRO A 157
 PEG  A 368 ( 4.5A)
None
None
None
 1.28A 2hdnB-3rf7A:
undetectable
2hdnC-3rf7A:
undetectable
2hdnD-3rf7A:
undetectable		 2hdnB-3rf7A:
21.05
2hdnC-3rf7A:
9.19
2hdnD-3rf7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		4 / 6 THR A  72
SER A 119
PRO A 157
SER A 118
 None
None
None
PEG  A 368 ( 4.5A)
 1.24A 2hdnI-3rf7A:
undetectable
2hdnJ-3rf7A:
undetectable
2hdnL-3rf7A:
undetectable		 2hdnI-3rf7A:
9.19
2hdnJ-3rf7A:
21.05
2hdnL-3rf7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		4 / 6 SER A 118
THR A  72
SER A 119
PRO A 157
 PEG  A 368 ( 4.5A)
None
None
None
 1.24A 2hdnJ-3rf7A:
undetectable
2hdnK-3rf7A:
undetectable
2hdnL-3rf7A:
undetectable		 2hdnJ-3rf7A:
21.05
2hdnK-3rf7A:
9.19
2hdnL-3rf7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		5 / 10 ASP A 104
GLY A 100
GLY A 137
ILE A 173
THR A 168
 NAD  A 358 (-2.7A)
NAD  A 358 (-3.2A)
None
None
None
 1.05A 3el9B-3rf7A:
undetectable		 3el9B-3rf7A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		5 / 9 ASP A 104
GLY A 100
GLY A 137
ILE A 173
THR A 168
 NAD  A 358 (-2.7A)
NAD  A 358 (-3.2A)
None
None
None
 1.03A 3gguB-3rf7A:
undetectable		 3gguB-3rf7A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		5 / 10 VAL A  95
LEU A 179
GLY A  96
VAL A  41
GLY A  98
 None
 1.17A 3ls4H-3rf7A:
undetectable		 3ls4H-3rf7A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		3 / 3 LYS A  48
PRO A  49
LEU A  50
 NAD  A 358 (-4.6A)
None
None
 0.66A 3tpxE-3rf7A:
undetectable		 3tpxE-3rf7A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		6 / 12 SER A 242
GLY A 143
GLY A 137
GLY A 145
VAL A  95
ILE A 138
 None
 1.37A 4ctkC-3rf7A:
undetectable		 4ctkC-3rf7A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		4 / 7 HIS A 198
ASP A 194
HIS A 258
VAL A 153
 FE  A 360 ( 3.4A)
FE  A 360 (-2.0A)
NI  A 361 ( 3.1A)
NAD  A 358 (-4.2A)
 1.02A 4hvrA-3rf7A:
undetectable		 4hvrA-3rf7A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		5 / 12 ALA A 146
MET A 103
ALA A 108
GLY A 162
LEU A 163
 NAD  A 358 (-3.7A)
None
None
CL  A 364 (-3.5A)
None
 1.04A 4oaeA-3rf7A:
undetectable		 4oaeA-3rf7A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		5 / 12 HIS A 272
ILE A 249
HIS A 198
GLU A 201
SER A 261
 NI  A 361 (-3.4A)
None
FE  A 360 ( 3.4A)
None
None
 1.29A 4r88B-3rf7A:
undetectable		 4r88B-3rf7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		5 / 12 HIS A 272
ILE A 249
HIS A 198
GLU A 201
SER A 261
 NI  A 361 (-3.4A)
None
FE  A 360 ( 3.4A)
None
None
 1.27A 4r88C-3rf7A:
undetectable		 4r88C-3rf7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		5 / 12 HIS A 272
ILE A 249
HIS A 198
GLU A 201
SER A 261
 NI  A 361 (-3.4A)
None
FE  A 360 ( 3.4A)
None
None
 1.27A 4r88F-3rf7A:
undetectable		 4r88F-3rf7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		5 / 12 SER A 119
THR A  73
GLN A  75
ALA A 108
THR A 168
 None
None
CL  A 362 (-4.3A)
None
None
 1.27A 5d0xH-3rf7A:
undetectable
5d0xI-3rf7A:
undetectable		 5d0xH-3rf7A:
21.18
5d0xI-3rf7A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		3 / 3 HIS A 198
ASP A 194
HIS A 272
 FE  A 360 ( 3.4A)
FE  A 360 (-2.0A)
NI  A 361 (-3.4A)
 0.73A 5oexA-3rf7A:
undetectable		 5oexA-3rf7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		3 / 3 HIS A 272
ASP A 194
HIS A 198
 NI  A 361 (-3.4A)
FE  A 360 (-2.0A)
FE  A 360 ( 3.4A)
 0.45A 5oexA-3rf7A:
undetectable		 5oexA-3rf7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		3 / 3 HIS A 198
ASP A 194
HIS A 272
 FE  A 360 ( 3.4A)
FE  A 360 (-2.0A)
NI  A 361 (-3.4A)
 0.74A 5oexB-3rf7A:
undetectable		 5oexB-3rf7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		3 / 3 HIS A 272
ASP A 194
HIS A 198
 NI  A 361 (-3.4A)
FE  A 360 (-2.0A)
FE  A 360 ( 3.4A)
 0.42A 5oexB-3rf7A:
undetectable		 5oexB-3rf7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		3 / 3 HIS A 198
ASP A 194
HIS A 272
 FE  A 360 ( 3.4A)
FE  A 360 (-2.0A)
NI  A 361 (-3.4A)
 0.71A 5oexC-3rf7A:
undetectable		 5oexC-3rf7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		3 / 3 HIS A 272
ASP A 194
HIS A 198
 NI  A 361 (-3.4A)
FE  A 360 (-2.0A)
FE  A 360 ( 3.4A)
 0.40A 5oexC-3rf7A:
undetectable		 5oexC-3rf7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		3 / 3 HIS A 198
ASP A 194
HIS A 272
 FE  A 360 ( 3.4A)
FE  A 360 (-2.0A)
NI  A 361 (-3.4A)
 0.71A 5oexD-3rf7A:
undetectable		 5oexD-3rf7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		3 / 3 HIS A 272
ASP A 194
HIS A 198
 NI  A 361 (-3.4A)
FE  A 360 (-2.0A)
FE  A 360 ( 3.4A)
 0.42A 5oexD-3rf7A:
undetectable		 5oexD-3rf7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		5 / 12 GLY A 100
ASP A 194
GLY A 246
SER A 149
PHE A 170
 NAD  A 358 (-3.2A)
FE  A 360 (-2.0A)
None
NAD  A 358 (-2.5A)
None
 1.19A 5vooF-3rf7A:
undetectable		 5vooF-3rf7A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		5 / 12 ILE A 197
THR A 325
VAL A 324
VAL A 322
VAL A 153
 None
None
None
None
NAD  A 358 (-4.2A)
 1.31A 6bzoC-3rf7A:
0.1		 6bzoC-3rf7A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE
(Shewanella
denitrificans) 		4 / 5 TYR A 207
VAL A 169
MET A 328
GLY A 329
 None
 1.25A 6hd4A-3rf7A:
undetectable		 6hd4A-3rf7A:
12.37