SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_A_MTXA1278_1
(PTERIDINE REDUCTASE
2)		 3rfe PLATELET
GLYCOPROTEIN IB BETA
CHAIN
(Homo
sapiens) 		5 / 10 ASP A  51
LEU A  56
LEU A  79
PRO A  83
TYR A  88
 None
 1.44A 1mxfA-3rfeA:
undetectable		 1mxfA-3rfeA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)		 3rfe PLATELET
GLYCOPROTEIN IB BETA
CHAIN
(Homo
sapiens) 		5 / 11 ASP A  51
LEU A  56
LEU A  79
PRO A  83
TYR A  88
 None
 1.46A 1mxfC-3rfeA:
undetectable		 1mxfC-3rfeA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_D_MTXD4278_1
(PTERIDINE REDUCTASE
2)		 3rfe PLATELET
GLYCOPROTEIN IB BETA
CHAIN
(Homo
sapiens) 		5 / 11 ASP A  51
LEU A  56
LEU A  79
PRO A  83
TYR A  88
 None
 1.49A 1mxfD-3rfeA:
undetectable		 1mxfD-3rfeA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3rfe PLATELET
GLYCOPROTEIN IB BETA
CHAIN
(Homo
sapiens) 		4 / 5 PRO A   4
GLY A  18
ASN A  40
GLY A  15
 None
NAG  A 130 (-4.0A)
None
None
 1.00A 1zlqA-3rfeA:
undetectable		 1zlqA-3rfeA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 3rfe PLATELET
GLYCOPROTEIN IB BETA
CHAIN
(Homo
sapiens) 		5 / 10 LEU A 107
LEU A  72
LEU A 104
ARG A 102
ARG A  92
 None
None
None
None
SO4  A 133 (-2.8A)
 0.88A 2riwA-3rfeA:
undetectable
2riwB-3rfeA:
undetectable		 2riwA-3rfeA:
14.50
2riwB-3rfeA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3rfe PLATELET
GLYCOPROTEIN IB BETA
CHAIN
(Homo
sapiens) 		5 / 12 TRP A  21
ALA A  52
VAL A  12
LEU A  42
LEU A  61
 None
 1.30A 3b0wB-3rfeA:
undetectable		 3b0wB-3rfeA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 3rfe PLATELET
GLYCOPROTEIN IB BETA
CHAIN
(Homo
sapiens) 		4 / 6 ARG A  17
GLY A  15
SER A   6
VAL A  36
 None
 1.23A 5ysiA-3rfeA:
undetectable		 5ysiA-3rfeA:
21.02