SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rfn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_B_AZMB263_1
(CARBONIC ANHYDRASE 9)		 3rfn BB_1WNU_001
(Pyrococcus
horikoshii) 		5 / 11 HIS A  13
HIS A   9
VAL A  20
LEU A  42
THR A  33
 ZN  A   1 (-3.3A)
ZN  A   1 (-3.3A)
None
None
None
 1.32A 3iaiB-3rfnA:
undetectable		 3iaiB-3rfnA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 3rfn BB_1WNU_001
(Pyrococcus
horikoshii) 		5 / 12 HIS A 147
LEU A  12
HIS A  13
THR A   8
TYR A  34
 None
None
ZN  A   1 (-3.3A)
None
None
 1.24A 3thrA-3rfnA:
undetectable
3thrB-3rfnA:
undetectable
3thrC-3rfnA:
undetectable
3thrD-3rfnA:
undetectable		 3thrA-3rfnA:
20.97
3thrB-3rfnA:
20.97
3thrC-3rfnA:
20.97
3thrD-3rfnA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3rfn BB_1WNU_001
(Pyrococcus
horikoshii) 		3 / 3 PHE A  86
VAL A 107
GLU A 109
 None
 0.70A 4fvqA-3rfnA:
undetectable		 4fvqA-3rfnA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 3rfn BB_1WNU_001
(Pyrococcus
horikoshii) 		4 / 5 HIS A 147
VAL A 135
GLU A 145
VAL A  41
 None
 1.22A 4p6vB-3rfnA:
undetectable
4p6vE-3rfnA:
undetectable		 4p6vB-3rfnA:
16.51
4p6vE-3rfnA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3rfn BB_1WNU_001
(Pyrococcus
horikoshii) 		4 / 6 ILE A  43
GLY A  17
ASN A 112
ILE A 146
 None
 0.78A 5j4nB-3rfnA:
undetectable		 5j4nB-3rfnA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 3rfn BB_1WNU_001
(Pyrococcus
horikoshii) 		3 / 3 GLU A   5
HIS A   9
VAL A  35
 None
ZN  A   1 (-3.3A)
None
 0.52A 5trqB-3rfnA:
undetectable		 5trqB-3rfnA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 3rfn BB_1WNU_001
(Pyrococcus
horikoshii) 		4 / 6 ALA A 115
VAL A 113
ASP A  92
TYR A  91
 None
 1.20A 5umd2-3rfnA:
undetectable
5umdF-3rfnA:
undetectable		 5umd2-3rfnA:
17.07
5umdF-3rfnA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 3rfn BB_1WNU_001
(Pyrococcus
horikoshii) 		4 / 6 LEU A 150
THR A   8
GLY A  40
ARG A 133
 None
 1.36A 6gtqB-3rfnA:
undetectable
6gtqD-3rfnA:
undetectable		 6gtqB-3rfnA:
21.35
6gtqD-3rfnA:
12.58