SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rfq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3rfq PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
MOAB2
(Mycobacterium
marinum) 		4 / 8 LEU A  87
ALA A  28
PHE A  58
VAL A  60
 None
 0.73A 1epbB-3rfqA:
undetectable		 1epbB-3rfqA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 3rfq PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
MOAB2
(Mycobacterium
marinum) 		5 / 12 LEU A  87
VAL A  63
LEU A 151
MET A 162
LEU A  52
 None
 1.41A 1nhzA-3rfqA:
undetectable		 1nhzA-3rfqA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 3rfq PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
MOAB2
(Mycobacterium
marinum) 		5 / 10 ASP A 132
GLY A 153
ALA A 152
ILE A 121
GLY A 161
 None
 0.95A 1t3rA-3rfqA:
undetectable		 1t3rA-3rfqA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 3rfq PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
MOAB2
(Mycobacterium
marinum) 		5 / 10 ASP A 132
GLY A 153
ALA A 152
ILE A 121
GLY A 161
 None
 0.92A 1t7iA-3rfqA:
undetectable		 1t7iA-3rfqA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 3rfq PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
MOAB2
(Mycobacterium
marinum) 		4 / 7 THR A  94
GLY A 138
THR A 102
VAL A 149
 None
 0.94A 4qwpB-3rfqA:
undetectable		 4qwpB-3rfqA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 3rfq PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
MOAB2
(Mycobacterium
marinum) 		5 / 9 ALA A 157
ASP A 160
ILE A 121
GLY A 134
PRO A 103
 None
NA  A 181 (-3.3A)
None
None
None
 1.18A 5kr2A-3rfqA:
undetectable		 5kr2A-3rfqA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 3rfq PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
MOAB2
(Mycobacterium
marinum) 		5 / 9 ALA A 157
ASP A 160
ILE A 121
GLY A 134
PRO A 103
 None
NA  A 181 (-3.3A)
None
None
None
 1.31A 5kr2C-3rfqA:
undetectable		 5kr2C-3rfqA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 3rfq PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
MOAB2
(Mycobacterium
marinum) 		4 / 8 PRO A 167
ILE A 117
ALA A 120
ILE A 121
 None
 0.43A 5mvmA-3rfqA:
undetectable
5mvmB-3rfqA:
undetectable		 5mvmA-3rfqA:
21.02
5mvmB-3rfqA:
21.02