SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rfr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 3rfr PMOA
(Methylocystis
sp.
M) 		3 / 3 TRP J 157
VAL J 151
TRP J 135
 None
 0.90A 1gmkC-3rfrJ:
undetectable
1gmkD-3rfrJ:
undetectable		 1gmkC-3rfrJ:
6.14
1gmkD-3rfrJ:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 3rfr PMOB
(Methylocystis
sp.
M) 		3 / 3 ASP A 382
LEU A 376
LEU A 379
 None
 0.56A 1ikeA-3rfrA:
undetectable		 1ikeA-3rfrA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 3rfr PMOB
(Methylocystis
sp.
M) 		5 / 10 LEU A 342
GLU A 374
LEU A 376
ALA A 321
GLY A 389
 None
 1.40A 1mjqC-3rfrA:
undetectable
1mjqD-3rfrA:
undetectable		 1mjqC-3rfrA:
13.72
1mjqD-3rfrA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 3rfr PMOA
(Methylocystis
sp.
M) 		4 / 5 VAL J 152
GLY J 153
VAL J 151
TRP J 157
 None
 1.28A 1tkqB-3rfrJ:
undetectable		 1tkqB-3rfrJ:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 3rfr PMOA
(Methylocystis
sp.
M) 		4 / 6 TRP J 157
LEU J 155
LEU J 159
PRO J  70
 None
 1.20A 2dqyC-3rfrJ:
undetectable		 2dqyC-3rfrJ:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3rfr PMOA
(Methylocystis
sp.
M) 		4 / 7 VAL J  57
SER J 122
PHE J 193
HIS J 192
 None
 1.06A 2f78A-3rfrJ:
undetectable		 2f78A-3rfrJ:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3rfr PMOA
(Methylocystis
sp.
M) 		4 / 7 VAL J  57
SER J 122
PHE J 193
HIS J 192
 None
 1.04A 2f78B-3rfrJ:
undetectable		 2f78B-3rfrJ:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3rfr PMOA
(Methylocystis
sp.
M) 		4 / 6 VAL J  57
SER J 122
PHE J 193
HIS J 192
 None
 1.00A 2f8dA-3rfrJ:
undetectable		 2f8dA-3rfrJ:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 3rfr PMOB
(Methylocystis
sp.
M) 		3 / 3 PRO A 339
GLY A 150
TYR A 341
 None
 0.65A 2vouA-3rfrA:
undetectable		 2vouA-3rfrA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 3rfr PMOB
(Methylocystis
sp.
M) 		3 / 3 PRO A 339
GLY A 150
TYR A 341
 None
 0.67A 2vouB-3rfrA:
undetectable		 2vouB-3rfrA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 3rfr PMOB
(Methylocystis
sp.
M) 		3 / 3 PRO A 339
GLY A 150
TYR A 341
 None
 0.67A 2vouC-3rfrA:
undetectable		 2vouC-3rfrA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 3rfr PMOB
(Methylocystis
sp.
M) 		3 / 3 VAL A 277
ASN A  44
TRP A  45
 None
 1.04A 2y00B-3rfrA:
undetectable		 2y00B-3rfrA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 3rfr PMOA
(Methylocystis
sp.
M) 		4 / 6 ILE J 189
ARG J 195
PRO J 120
VAL J  98
 None
 1.17A 2ygoA-3rfrJ:
undetectable		 2ygoA-3rfrJ:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3rfr PMOB
(Methylocystis
sp.
M) 		5 / 12 SER A  71
ALA A  72
GLY A 407
VAL A 387
GLY A 388
 None
 1.14A 3f8wA-3rfrA:
undetectable		 3f8wA-3rfrA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3rfr PMOB
(Methylocystis
sp.
M) 		5 / 12 SER A  71
HIS A  68
GLY A 407
VAL A 387
GLY A 388
 None
 0.95A 3f8wB-3rfrA:
undetectable		 3f8wB-3rfrA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3rfr PMOB
(Methylocystis
sp.
M) 		6 / 12 SER A  71
HIS A  68
ALA A  72
GLY A 407
VAL A 387
GLY A 388
 None
 1.14A 3f8wC-3rfrA:
undetectable		 3f8wC-3rfrA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3rfr PMOA
(Methylocystis
sp.
M) 		3 / 3 GLY J 115
THR J 117
ASN J 112
 None
 0.71A 3v4tD-3rfrJ:
undetectable		 3v4tD-3rfrJ:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 3rfr PMOB
(Methylocystis
sp.
M) 		4 / 5 GLY A 323
ALA A 322
GLY A 148
PRO A 149
 None
 0.93A 4u9uA-3rfrA:
undetectable		 4u9uA-3rfrA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 3rfr PMOB
(Methylocystis
sp.
M) 		4 / 5 GLY A 323
ALA A 322
GLY A 148
PRO A 149
 None
 0.95A 4u9uB-3rfrA:
undetectable		 4u9uB-3rfrA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3rfr PMOB
(Methylocystis
sp.
M) 		5 / 12 TRP A  45
GLY A  88
ASN A 139
PHE A 120
ILE A 122
 None
 1.21A 4zvmA-3rfrA:
undetectable
4zvmB-3rfrA:
undetectable		 4zvmA-3rfrA:
20.66
4zvmB-3rfrA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3rfr PMOB
(Methylocystis
sp.
M) 		5 / 10 TRP A  45
GLY A  88
ASN A 139
PHE A 120
ILE A 122
 None
 1.17A 5lbtA-3rfrA:
undetectable
5lbtB-3rfrA:
undetectable		 5lbtA-3rfrA:
20.24
5lbtB-3rfrA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 3rfr PMOB
(Methylocystis
sp.
M) 		4 / 7 GLY A  65
TYR A 341
TRP A  50
ASP A 117
 None
 1.10A 5vlmE-3rfrA:
undetectable		 5vlmE-3rfrA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 3rfr PMOB
(Methylocystis
sp.
M) 		3 / 3 LEU A 236
ASP A 226
ILE A 224
 None
 0.46A 6dh0B-3rfrA:
undetectable		 6dh0B-3rfrA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 3rfr PMOA
(Methylocystis
sp.
M) 		4 / 5 ASN J 108
TYR J  42
GLY J  41
HIS J  43
 None
 1.19A 6gh9A-3rfrJ:
undetectable		 6gh9A-3rfrJ:
15.11