SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rft'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		4 / 6 LYS A 140
LEU A  91
THR A 114
LEU A 146
 None
 1.13A 1etb2-3rftA:
undetectable		 1etb2-3rftA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		4 / 6 ALA A 159
SER A 181
ARG A 194
LEU A 198
 None
 1.16A 1gahA-3rftA:
undetectable		 1gahA-3rftA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		4 / 5 GLY A 205
TRP A 204
VAL A 202
SER A 110
 None
 1.27A 1p6kB-3rftA:
undetectable		 1p6kB-3rftA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		4 / 5 GLY A 205
TRP A 204
VAL A 202
SER A 110
 None
 1.27A 1rs6B-3rftA:
undetectable		 1rs6B-3rftA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		3 / 3 ALA A 159
VAL A 202
TRP A 204
 None
 0.99A 1tkqA-3rftA:
undetectable		 1tkqA-3rftA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		3 / 3 ARG A   5
ARG A  31
ILE A  68
 SO4  A 268 (-3.0A)
None
None
 0.81A 1uobA-3rftA:
undetectable		 1uobA-3rftA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		4 / 5 GLY A 205
TRP A 204
VAL A 202
SER A 110
 None
 1.27A 1zzuB-3rftA:
undetectable		 1zzuB-3rftA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 10 PHE A 193
TYR A  95
LEU A   7
VAL A   8
LEU A   6
 None
 1.45A 2w98A-3rftA:
5.5		 2w98A-3rftA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		4 / 5 VAL A  18
VAL A 186
ASP A 183
SER A 181
 None
None
SO4  A 269 ( 4.2A)
None
 1.30A 2x45A-3rftA:
undetectable		 2x45A-3rftA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		4 / 4 GLY A 205
TRP A 204
VAL A 202
SER A 110
 None
 1.27A 3n62A-3rftA:
0.0		 3n62A-3rftA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		4 / 4 GLY A 205
TRP A 204
VAL A 202
SER A 110
 None
 1.30A 3n65A-3rftA:
0.0		 3n65A-3rftA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		4 / 4 GLY A 205
TRP A 204
VAL A 202
SER A 110
 None
 1.30A 3n66A-3rftA:
0.0		 3n66A-3rftA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 10 GLY A  90
ASP A  51
GLY A  72
VAL A  62
VAL A  58
 None
 0.98A 3nu9B-3rftA:
undetectable		 3nu9B-3rftA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 11 ILE A  83
ILE A  74
GLY A  73
SER A 165
ARG A 174
 None
None
None
SO4  A 270 (-3.0A)
SO4  A 270 (-2.9A)
 0.88A 4ac9B-3rftA:
6.5
4ac9C-3rftA:
6.5		 4ac9B-3rftA:
18.16
4ac9C-3rftA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 12 ILE A 106
LEU A   7
GLY A  67
VAL A  62
ALA A  63
 None
 1.24A 4fqsA-3rftA:
undetectable		 4fqsA-3rftA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 12 ILE A 106
LEU A   7
GLY A  67
VAL A  62
ALA A  63
 None
 1.23A 4fqsB-3rftA:
undetectable		 4fqsB-3rftA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 9 GLY A 255
GLY A 256
ARG A 174
GLY A 116
ASP A 133
 None
None
SO4  A 270 (-2.9A)
None
None
 0.98A 4h2gA-3rftA:
undetectable		 4h2gA-3rftA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 11 GLY A  90
GLY A  73
ALA A  53
LEU A  52
GLN A  82
 None
 1.12A 4l8fD-3rftA:
4.2		 4l8fD-3rftA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		4 / 6 LYS A 140
LEU A  91
THR A 114
LEU A 146
 None
 1.06A 4pwjA-3rftA:
undetectable		 4pwjA-3rftA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 12 GLY A 143
LEU A  52
ILE A  68
THR A   9
GLY A  90
 None
 0.88A 5hieB-3rftA:
undetectable		 5hieB-3rftA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 12 PRO A 201
ILE A 189
ILE A  68
LEU A  71
THR A   9
 None
 1.10A 5tiwB-3rftA:
2.1		 5tiwB-3rftA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		4 / 5 GLY A 205
TRP A 204
VAL A 202
SER A 110
 None
 1.30A 5vunA-3rftA:
undetectable		 5vunA-3rftA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		4 / 6 LEU A  23
VAL A  69
LEU A  71
VAL A 107
 None
 0.88A 5x7zA-3rftA:
undetectable		 5x7zA-3rftA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3rft URONATE
DEHYDROGENASE
(Agrobacterium
fabrum) 		5 / 10 ASP A 248
GLY A 256
GLN A 120
VAL A 251
ASN A 172
 None
 1.26A 6nqaK-3rftA:
3.0		 6nqaK-3rftA:
20.73