SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rfy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 GLU A 214
LYS A 208
VAL A 210
 None
 0.91A 1l2iA-3rfyA:
undetectable		 1l2iA-3rfyA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 ASN A 115
VAL A 121
GLY A 157
ILE A 161
ILE A 118
 None
 0.93A 1n49B-3rfyA:
undetectable		 1n49B-3rfyA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 ASN A 115
VAL A 121
GLY A 157
ILE A 161
ILE A 118
 None
 0.92A 1n49C-3rfyA:
undetectable		 1n49C-3rfyA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 211
ILE A 160
ILE A 177
ILE A 206
ILE A 118
 None
 1.01A 2hs1A-3rfyA:
undetectable		 2hs1A-3rfyA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 VAL A  93
ILE A  95
GLY A 293
LEU A 376
ILE A 349
 None
 0.90A 3em6B-3rfyA:
undetectable		 3em6B-3rfyA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 THR A 401
LEU A 262
VAL A 422
ASP A 242
VAL A 421
 None
 1.11A 4c9pB-3rfyA:
undetectable		 4c9pB-3rfyA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 VAL A 278
SER A  92
TYR A 283
LEU A 262
 None
 0.90A 4hxyB-3rfyA:
undetectable		 4hxyB-3rfyA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 220
ALA A 239
GLY A 237
PHE A 221
TYR A 265
 None
 1.20A 4r29A-3rfyA:
undetectable		 4r29A-3rfyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 220
ALA A 239
GLY A 237
PHE A 221
TYR A 265
 None
 1.17A 4r29B-3rfyA:
undetectable		 4r29B-3rfyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 220
ALA A 239
GLY A 237
PHE A 221
TYR A 265
 None
 1.20A 4r29C-3rfyA:
undetectable		 4r29C-3rfyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 TYR A 109
TYR A 399
GLU A 126
ASP A 130
 None
 1.26A 4x61A-3rfyA:
undetectable		 4x61A-3rfyA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 TYR A 109
TYR A 399
GLU A 126
ASP A 130
 None
 1.30A 5emlA-3rfyA:
undetectable		 5emlA-3rfyA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 THR A 270
PRO A 384
LEU A 234
MET A 232
 None
 0.99A 5fxtA-3rfyA:
undetectable		 5fxtA-3rfyA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 VAL A 295
VAL A  93
ARG A 290
ILE A 288
 None
 1.03A 5jw1B-3rfyA:
undetectable		 5jw1B-3rfyA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3rfy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP38, CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 VAL A 422
PHE A 274
VAL A 400
LEU A 262
VAL A 275
 None
 1.12A 5tudD-3rfyA:
2.3		 5tudD-3rfyA:
22.06