SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rgg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 3rgg PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, PURE
PROTEIN
(Treponema
denticola) 		5 / 11 GLY A  82
ILE A  85
ALA A 120
VAL A   5
ILE A  30
 None
 0.98A 2nnhA-3rggA:
undetectable		 2nnhA-3rggA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 3rgg PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, PURE
PROTEIN
(Treponema
denticola) 		5 / 12 PHE A 128
ALA A 125
ILE A  85
ALA A 112
GLY A  82
 None
 0.90A 3nxuA-3rggA:
undetectable		 3nxuA-3rggA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 3rgg PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, PURE
PROTEIN
(Treponema
denticola) 		5 / 10 ALA A  39
TYR A  62
LEU A  50
ILE A  34
ILE A  21
 None
 0.93A 3prsA-3rggA:
undetectable		 3prsA-3rggA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3rgg PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, PURE
PROTEIN
(Treponema
denticola) 		5 / 9 ILE A  30
ILE A   7
ILE A   6
MET A  49
ILE A  34
 None
 1.13A 3zosA-3rggA:
undetectable		 3zosA-3rggA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 3rgg PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, PURE
PROTEIN
(Treponema
denticola) 		4 / 6 THR A  27
GLY A  29
ILE A 135
LEU A  25
 None
 1.09A 4ac9C-3rggA:
8.5		 4ac9C-3rggA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3rgg PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, PURE
PROTEIN
(Treponema
denticola) 		4 / 6 THR A  27
GLY A  29
ILE A 135
LEU A  25
 None
 1.04A 4acaC-3rggA:
3.2		 4acaC-3rggA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3rgg PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, PURE
PROTEIN
(Treponema
denticola) 		4 / 6 THR A  27
GLY A  29
ILE A 135
LEU A  25
 None
 1.03A 4acbC-3rggA:
2.4		 4acbC-3rggA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3rgg PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, PURE
PROTEIN
(Treponema
denticola) 		5 / 11 THR A  42
GLY A  37
GLY A  10
SER A  11
SER A  13
 None
None
AIR  A1001 (-3.5A)
AIR  A1001 (-2.7A)
AIR  A1001 ( 3.7A)
 1.06A 4qvwK-3rggA:
undetectable
4qvwL-3rggA:
undetectable		 4qvwK-3rggA:
23.11
4qvwL-3rggA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3rgg PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, PURE
PROTEIN
(Treponema
denticola) 		5 / 11 THR A  42
GLY A  37
GLY A  10
SER A  11
SER A  13
 None
None
AIR  A1001 (-3.5A)
AIR  A1001 (-2.7A)
AIR  A1001 ( 3.7A)
 1.07A 4qvwY-3rggA:
undetectable
4qvwZ-3rggA:
undetectable		 4qvwY-3rggA:
23.11
4qvwZ-3rggA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3rgg PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, PURE
PROTEIN
(Treponema
denticola) 		4 / 6 ALA A 120
ILE A  34
SER A  73
ILE A  85
 None
 0.71A 4r21A-3rggA:
undetectable		 4r21A-3rggA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3rgg PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, PURE
PROTEIN
(Treponema
denticola) 		5 / 12 TYR A  62
ARG A  58
LEU A  56
ALA A  33
ILE A   7
 None
 1.39A 5ewjC-3rggA:
5.3
5ewjD-3rggA:
6.3		 5ewjC-3rggA:
19.39
5ewjD-3rggA:
18.46