SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rgw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.75A 1a7yA-3rgwL:
undetectable		 1a7yA-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.84A 1a7yB-3rgwL:
undetectable		 1a7yB-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		4 / 6 CYH L  78
VAL L  77
HIS L  82
CYH L 600
 NFU  L1004 (-2.2A)
None
NFU  L1004 (-4.0A)
NFU  L1004 (-2.2A)
 1.43A 1ekjG-3rgwL:
undetectable
1ekjH-3rgwL:
undetectable		 1ekjG-3rgwL:
15.97
1ekjH-3rgwL:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.74A 1i3wE-3rgwL:
undetectable		 1i3wE-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.79A 1i3wE-3rgwL:
undetectable		 1i3wE-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.75A 1i3wF-3rgwL:
undetectable		 1i3wF-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.79A 1i3wG-3rgwL:
undetectable		 1i3wG-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.82A 1i3wG-3rgwL:
undetectable		 1i3wG-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.82A 1i3wH-3rgwL:
undetectable		 1i3wH-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 12 VAL L  36
ASP L  37
LEU L 591
THR L 590
PRO L 577
 None
 1.40A 1ia0B-3rgwL:
undetectable		 1ia0B-3rgwL:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.76A 1mnvD-3rgwL:
undetectable		 1mnvD-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.75A 1mnvD-3rgwL:
undetectable		 1mnvD-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 ALA L  93
VAL L 523
TRP L 366
 None
 0.89A 1nt5A-3rgwL:
undetectable		 1nt5A-3rgwL:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 ALA L  93
VAL L 523
TRP L 366
 None
 0.89A 1nt5B-3rgwL:
undetectable		 1nt5B-3rgwL:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.77A 1ovfB-3rgwL:
undetectable		 1ovfB-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 CYH L  78
ARG L 530
CYH L  75
 NFU  L1004 (-2.2A)
NFU  L1004 (-4.2A)
NFU  L1004 (-2.2A)
 1.40A 1p9gA-3rgwL:
undetectable		 1p9gA-3rgwL:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.73A 1qfiA-3rgwL:
undetectable		 1qfiA-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.86A 1qfiB-3rgwL:
undetectable		 1qfiB-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 ASP L 117
LEU L 113
HIS L 603
 None
None
MG  L1005 (-3.4A)
 0.77A 1qknA-3rgwL:
undetectable		 1qknA-3rgwL:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		4 / 8 ALA L 420
TYR L 417
LEU L 419
GLY L 323
 None
 0.86A 1rukH-3rgwL:
undetectable
1rukL-3rgwL:
undetectable		 1rukH-3rgwL:
15.74
1rukL-3rgwL:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 ALA L 506
VAL L 234
TRP L  68
 None
 0.84A 1tkqB-3rgwL:
undetectable		 1tkqB-3rgwL:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 12 VAL L  36
ASP L  37
LEU L 591
THR L 590
PRO L 577
 None
 1.40A 1tubB-3rgwL:
undetectable		 1tubB-3rgwL:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.81A 1unjF-3rgwL:
undetectable		 1unjF-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.75A 1unjF-3rgwL:
undetectable		 1unjF-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.87A 1unjL-3rgwL:
undetectable		 1unjL-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.85A 1unjL-3rgwL:
undetectable		 1unjL-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.87A 1unjR-3rgwL:
undetectable		 1unjR-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.82A 1unjR-3rgwL:
undetectable		 1unjR-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.86A 1unjX-3rgwL:
undetectable		 1unjX-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.84A 1unjX-3rgwL:
undetectable		 1unjX-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.87A 1unmF-3rgwL:
undetectable		 1unmF-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 553
THR L 554
PRO L 552
 NFU  L1004 (-3.8A)
None
NFU  L1004 (-3.6A)
 0.86A 1unmF-3rgwL:
undetectable		 1unmF-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 12 TYR L 192
ALA L 290
TYR L 287
GLY L 291
VAL L 585
 None
 1.29A 1vpoH-3rgwL:
undetectable
1vpoL-3rgwL:
undetectable		 1vpoH-3rgwL:
17.58
1vpoL-3rgwL:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 12 ALA L 532
GLY L 323
GLY L 324
MET L 409
LEU L 327
 None
 1.03A 1ya4A-3rgwL:
undetectable		 1ya4A-3rgwL:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YNN_C_RFPC1120_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 12 ARG L 403
SER L 601
LEU L 598
PRO L 559
ILE L 399
 None
 1.44A 1ynnC-3rgwL:
0.3		 1ynnC-3rgwL:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		4 / 5 PRO L 339
GLY L 524
ASN L  92
GLY L 522
 None
 1.17A 1zlqA-3rgwL:
undetectable		 1zlqA-3rgwL:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 10 ILE L 222
ILE L 219
VAL L 253
ILE L 108
ILE L 105
 None
 1.12A 3p4wD-3rgwL:
1.2		 3p4wD-3rgwL:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		4 / 8 LEU L 321
GLN L 114
TYR L 309
TYR L 417
 None
 1.31A 3po7A-3rgwL:
undetectable		 3po7A-3rgwL:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 12 LEU L 113
THR L 553
THR L 554
ILE L 399
ILE L  74
 None
NFU  L1004 (-3.8A)
None
None
None
 1.18A 3sp9A-3rgwL:
undetectable		 3sp9A-3rgwL:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		4 / 6 GLY L 567
PRO L 559
TYR L 396
GLY L  49
 None
 0.84A 4fjpA-3rgwL:
undetectable		 4fjpA-3rgwL:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 THR L 554
PRO L 552
THR L 553
 None
NFU  L1004 (-3.6A)
NFU  L1004 (-3.8A)
 0.82A 4hivD-3rgwL:
undetectable		 4hivD-3rgwL:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		4 / 5 LEU L 194
TRP L 130
ILE L 470
ASN L 446
 None
 1.45A 4i00A-3rgwL:
undetectable		 4i00A-3rgwL:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 ILE L  98
ALA L 102
GLY L 224
TYR L 232
GLU L  91
 None
 1.50A 4jdsD-3rgwL:
1.2		 4jdsD-3rgwL:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 12 ILE L  98
ALA L 102
GLY L 224
TYR L 232
GLU L  91
 None
 1.25A 4jlgA-3rgwL:
undetectable		 4jlgA-3rgwL:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 ILE L  98
ALA L 102
GLY L 224
TYR L 232
GLU L  91
 None
 1.16A 4jlgB-3rgwL:
undetectable		 4jlgB-3rgwL:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		4 / 5 GLU L 197
ARG L 143
PRO L 196
SER L 135
 None
 1.44A 4k17B-3rgwL:
undetectable		 4k17B-3rgwL:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 12 SER L 601
LEU L 598
PRO L 559
ILE L 399
ARG L 403
 None
 1.36A 4kmuC-3rgwL:
undetectable		 4kmuC-3rgwL:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 12 SER L 601
LEU L 598
PRO L 559
ILE L 399
ARG L 403
 None
 1.46A 4kmuH-3rgwL:
undetectable		 4kmuH-3rgwL:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		4 / 8 THR L 525
VAL L 345
VAL L 411
ASP L 305
 None
 1.07A 4l4dA-3rgwL:
undetectable		 4l4dA-3rgwL:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 12 ALA L 568
GLY L   8
SER L 572
GLY L 297
ASP L 561
 None
 1.22A 4mm8A-3rgwL:
undetectable		 4mm8A-3rgwL:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		4 / 8 LEU L 147
LEU L 150
VAL L 151
ILE L 449
 None
 0.74A 4oj4A-3rgwL:
undetectable		 4oj4A-3rgwL:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		4 / 5 ARG L  31
THR L  50
THR L  48
TYR L 374
 None
 1.22A 4oltB-3rgwL:
0.0		 4oltB-3rgwL:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.33A 4qvmV-3rgwL:
undetectable
4qvmb-3rgwL:
undetectable		 4qvmV-3rgwL:
16.21
4qvmb-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.33A 4qvmH-3rgwL:
undetectable
4qvmN-3rgwL:
undetectable		 4qvmH-3rgwL:
16.21
4qvmN-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.34A 4qvpV-3rgwL:
undetectable
4qvpb-3rgwL:
undetectable		 4qvpV-3rgwL:
16.21
4qvpb-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.32A 4qvqV-3rgwL:
undetectable
4qvqb-3rgwL:
undetectable		 4qvqV-3rgwL:
16.21
4qvqb-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.33A 4qvqH-3rgwL:
undetectable
4qvqN-3rgwL:
undetectable		 4qvqH-3rgwL:
16.21
4qvqN-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.34A 4qvwH-3rgwL:
undetectable
4qvwN-3rgwL:
undetectable		 4qvwH-3rgwL:
16.21
4qvwN-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.32A 4qw3V-3rgwL:
undetectable
4qw3b-3rgwL:
undetectable		 4qw3V-3rgwL:
16.21
4qw3b-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.33A 4qw3H-3rgwL:
undetectable
4qw3N-3rgwL:
undetectable		 4qw3H-3rgwL:
16.21
4qw3N-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		4 / 5 ARG L  31
THR L  50
THR L  48
TYR L 374
 None
 1.25A 4qwpB-3rgwL:
undetectable		 4qwpB-3rgwL:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.30A 5bxnV-3rgwL:
undetectable
5bxnb-3rgwL:
undetectable		 5bxnV-3rgwL:
16.21
5bxnb-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.34A 5cz7H-3rgwL:
undetectable
5cz7N-3rgwL:
undetectable		 5cz7H-3rgwL:
16.21
5cz7N-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.32A 5d0xV-3rgwL:
undetectable
5d0xb-3rgwL:
undetectable		 5d0xV-3rgwL:
16.21
5d0xb-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		3 / 3 ASP L  37
ASN L  44
PHE L   9
 None
 0.53A 5dsgB-3rgwL:
0.4		 5dsgB-3rgwL:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 12 VAL L 337
PHE L 335
ILE L 326
TRP L 331
ALA L 424
 None
 1.40A 5fctB-3rgwL:
undetectable		 5fctB-3rgwL:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 12 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.30A 5l5zV-3rgwL:
undetectable
5l5zb-3rgwL:
undetectable		 5l5zV-3rgwL:
16.21
5l5zb-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 12 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.30A 5l5zH-3rgwL:
undetectable
5l5zN-3rgwL:
undetectable		 5l5zH-3rgwL:
16.21
5l5zN-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.30A 5l66V-3rgwL:
undetectable
5l66b-3rgwL:
undetectable		 5l66V-3rgwL:
16.21
5l66b-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 11 HIS L 603
THR L 553
THR L 554
GLY L  28
ALA L 599
 MG  L1005 (-3.4A)
NFU  L1004 (-3.8A)
None
None
None
 1.30A 5l66H-3rgwL:
undetectable
5l66N-3rgwL:
undetectable		 5l66H-3rgwL:
16.21
5l66N-3rgwL:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		5 / 12 ILE L 283
LEU L 128
VAL L 203
ASP L 279
LEU L 147
 None
 1.06A 5tiwB-3rgwL:
undetectable		 5tiwB-3rgwL:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		4 / 7 GLY L 284
GLN L 148
ASP L 279
TYR L 276
 None
 1.20A 5vlmG-3rgwL:
1.2		 5vlmG-3rgwL:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		4 / 5 GLY L  15
ASN L  35
ASP L  13
ARG L  17
 None
 1.37A 6dwdB-3rgwL:
undetectable
6dwdD-3rgwL:
undetectable		 6dwdB-3rgwL:
22.31
6dwdD-3rgwL:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		4 / 5 ARG L  17
GLY L  15
ASN L  35
ASP L  13
 None
 1.37A 6dwjB-3rgwL:
undetectable
6dwjD-3rgwL:
0.8		 6dwjB-3rgwL:
22.31
6dwjD-3rgwL:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		4 / 8 ASP L 279
TYR L 123
ASN L 272
VAL L 115
 None
 1.01A 6giqL-3rgwL:
undetectable
6giqP-3rgwL:
undetectable
6giqT-3rgwL:
undetectable		 6giqL-3rgwL:
21.83
6giqP-3rgwL:
16.17
6giqT-3rgwL:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG
(Cupriavidus
necator) 		4 / 7 HIS L 364
ARG L 405
HIS L 407
ASP L 341
 None
 1.35A 6mn4F-3rgwL:
undetectable		 6mn4F-3rgwL:
18.80