SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rhd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 5 THR A 101
THR A 138
HIS A 163
LEU A 176
 None
 1.28A 1d4fC-3rhdA:
4.4		 1d4fC-3rhdA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 SER A 286
ILE A 287
ASP A 289
ASP A 284
 None
 1.00A 1yc5A-3rhdA:
3.8		 1yc5A-3rhdA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLU A 453
ASN A 159
GLU A 241
LEU A 240
LEU A 442
 None
 1.30A 2ha6A-3rhdA:
undetectable		 2ha6A-3rhdA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLU A 453
ASN A 159
GLU A 241
LEU A 240
LEU A 442
 None
 1.26A 2ha6B-3rhdA:
undetectable		 2ha6B-3rhdA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 THR A 157
ARG A  58
ASP A 114
THR A 126
 None
 1.19A 2okcB-3rhdA:
2.0		 2okcB-3rhdA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A 282
MET A 280
MET A 294
 None
 0.93A 2vavF-3rhdA:
undetectable		 2vavF-3rhdA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 TYR A 393
GLU A 368
ASN A 141
 None
 0.94A 2y7hC-3rhdA:
3.3		 2y7hC-3rhdA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 249
LEU A 251
ILE A 387
ILE A 287
VAL A 358
 None
 1.07A 2ygqA-3rhdA:
undetectable		 2ygqA-3rhdA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A 287
LEU A 256
PHE A 291
LEU A 341
 None
 0.98A 3adxA-3rhdA:
undetectable		 3adxA-3rhdA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  62
ILE A 155
ALA A 148
ALA A 450
ALA A 154
 None
 1.13A 3mdtB-3rhdA:
undetectable		 3mdtB-3rhdA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A  62
PHE A 102
ILE A 155
ALA A 450
ALA A 154
 None
 1.00A 3mdtB-3rhdA:
undetectable		 3mdtB-3rhdA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  85
GLY A 315
GLN A 273
LEU A 308
ASN A  18
 None
 1.22A 3sxjA-3rhdA:
4.0		 3sxjA-3rhdA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  85
GLY A 315
GLN A 273
LEU A 308
ASN A  18
 None
 1.21A 3sxjB-3rhdA:
4.3		 3sxjB-3rhdA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A 422
ILE A 399
PHE A 410
MET A 384
 None
 1.24A 3tvxB-3rhdA:
undetectable		 3tvxB-3rhdA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 8 VAL A 326
TRP A 325
HIS A 322
PRO A 375
 None
 1.35A 3v35A-3rhdA:
undetectable		 3v35A-3rhdA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ASP A 403
THR A 401
LEU A 251
GLU A 381
 None
 1.40A 4a3pA-3rhdA:
0.4		 4a3pA-3rhdA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 5 HIS A 396
SER A 425
SER A 277
VAL A 278
 None
 1.36A 4a99D-3rhdA:
2.4		 4a99D-3rhdA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 THR A 220
PRO A 139
PHE A 434
ARG A 428
 None
 1.39A 4kf9A-3rhdA:
undetectable		 4kf9A-3rhdA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A 272
GLU A 368
THR A 369
 None
 0.38A 4kouA-3rhdA:
undetectable		 4kouA-3rhdA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A  30
ILE A 318
LEU A 171
GLY A  85
LYS A  86
 None
 1.15A 4l9qB-3rhdA:
undetectable		 4l9qB-3rhdA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 5 SER A 218
ALA A 239
PHE A 219
GLU A 241
 None
None
NAP  A 500 (-4.4A)
None
 1.00A 4m93B-3rhdA:
undetectable
4m93C-3rhdA:
undetectable		 4m93B-3rhdA:
16.31
4m93C-3rhdA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ASP A 206
GLY A 226
PRO A 139
THR A 138
ILE A 137
 None
None
None
None
NAP  A 500 (-4.4A)
 1.02A 4njvB-3rhdA:
undetectable		 4njvB-3rhdA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A 315
PRO A 316
GLN A 273
 None
 0.38A 4oltB-3rhdA:
0.9		 4oltB-3rhdA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 SER A 147
LEU A  31
VAL A 204
ASP A  13
ILE A 174
 None
 1.38A 4pghC-3rhdA:
3.5		 4pghC-3rhdA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A 315
PRO A 316
GLN A 273
 None
 0.28A 4qwpB-3rhdA:
0.9		 4qwpB-3rhdA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 5 SER A 147
ALA A 148
HIS A 163
LEU A 176
 None
 1.38A 5dzkb-3rhdA:
undetectable
5dzkp-3rhdA:
undetectable		 5dzkb-3rhdA:
18.14
5dzkp-3rhdA:
1.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 5 GLU A 368
GLY A 221
SER A 223
GLY A 226
 None
NAP  A 500 ( 3.8A)
None
None
 1.10A 5kprA-3rhdA:
undetectable		 5kprA-3rhdA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A 217
ALA A 233
ILE A 229
ALA A 239
LEU A 240
 None
 1.12A 5mvmA-3rhdA:
undetectable
5mvmE-3rhdA:
undetectable		 5mvmA-3rhdA:
12.06
5mvmE-3rhdA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3rhd LACTALDEHYDE
DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 MET A  14
ALA A  30
LEU A  31
ILE A   9
 None
 0.87A 5mvmB-3rhdA:
undetectable
5mvmC-3rhdA:
undetectable		 5mvmB-3rhdA:
12.06
5mvmC-3rhdA:
12.06