SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rhe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3rhe NAD-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 7 TRP A  86
GLU A  81
MET A  78
ILE A 118
 None
 1.43A 2nsiA-3rheA:
undetectable
2nsiB-3rheA:
undetectable		 2nsiA-3rheA:
18.31
2nsiB-3rheA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3rhe NAD-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE
(Legionella
pneumophila) 		4 / 7 TRP A  86
GLU A  81
MET A  78
ILE A 118
 None
 1.45A 2nsiC-3rheA:
undetectable
2nsiD-3rheA:
undetectable		 2nsiC-3rheA:
18.31
2nsiD-3rheA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)		 3rhe NAD-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 12 MET A 100
GLN A  72
VAL A  73
LEU A   7
ARG A  47
 None
 1.43A 3h52D-3rheA:
undetectable		 3h52D-3rheA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 3rhe NAD-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE
(Legionella
pneumophila) 		3 / 3 ARG A 117
TYR A  11
GLU A  68
 None
 0.68A 4zzbE-3rheA:
undetectable		 4zzbE-3rheA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 3rhe NAD-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE
(Legionella
pneumophila) 		5 / 12 LEU A 121
GLN A  72
VAL A  73
LEU A   7
ARG A  47
 None
 1.20A 5uc1A-3rheA:
undetectable		 5uc1A-3rheA:
18.06