SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rht'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		3 / 3 TRP A 141
ALA A 127
VAL A 131
 None
 0.94A 1c4dC-3rhtA:
undetectable
1c4dD-3rhtA:
undetectable		 1c4dC-3rhtA:
6.52
1c4dD-3rhtA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 12 VAL A  80
PHE A 244
LEU A  22
TYR A 240
TRP A 219
 None
 1.34A 1mmkA-3rhtA:
undetectable		 1mmkA-3rhtA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		4 / 4 GLY A 149
VAL A 213
TRP A  85
GLY A  84
 None
None
GOL  A 260 (-4.1A)
GOL  A 260 (-3.5A)
 1.32A 1ng8A-3rhtA:
undetectable		 1ng8A-3rhtA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		4 / 4 GLY A 149
VAL A 213
TRP A  85
GLY A  84
 None
None
GOL  A 260 (-4.1A)
GOL  A 260 (-3.5A)
 1.32A 1ng8B-3rhtA:
undetectable		 1ng8B-3rhtA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 12 LEU A 190
LEU A 191
VAL A 251
LEU A  82
ILE A 148
 None
 1.12A 1s9pD-3rhtA:
undetectable		 1s9pD-3rhtA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 12 GLU A  86
GLY A  93
TYR A  88
ASN A 152
ALA A  58
 None
 1.09A 2bm9C-3rhtA:
undetectable		 2bm9C-3rhtA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 12 GLU A  86
GLY A  93
TYR A  88
ASN A 152
ALA A  58
 None
 1.25A 2br4B-3rhtA:
undetectable		 2br4B-3rhtA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		4 / 5 LEU A 248
ILE A  52
LEU A  53
SER A  54
 None
None
None
CA  A 257 ( 4.0A)
 0.90A 2byoA-3rhtA:
undetectable		 2byoA-3rhtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		4 / 8 SER A  87
ASP A  55
SER A  54
ASN A 152
 None
GOL  A 260 ( 2.7A)
CA  A 257 ( 4.0A)
None
 1.09A 2cmlC-3rhtA:
undetectable		 2cmlC-3rhtA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 9 GLY A  83
SER A  54
LEU A  19
ASP A   9
ASP A  55
 None
CA  A 257 ( 4.0A)
None
CA  A 257 (-3.2A)
GOL  A 260 ( 2.7A)
 1.49A 2j2pB-3rhtA:
undetectable
2j2pC-3rhtA:
undetectable		 2j2pB-3rhtA:
21.72
2j2pC-3rhtA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 12 ALA A 202
LEU A 248
LEU A  82
PHE A 204
LEU A 216
 None
 1.28A 2oipB-3rhtA:
undetectable		 2oipB-3rhtA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 12 ALA A 202
LEU A 248
LEU A  82
SER A 206
LEU A 216
 None
 1.17A 2oipB-3rhtA:
undetectable		 2oipB-3rhtA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 12 ALA A 202
LEU A 248
LEU A  82
SER A 206
LEU A 216
 None
 1.15A 2oipC-3rhtA:
undetectable		 2oipC-3rhtA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 12 ALA A 202
LEU A 248
LEU A  82
SER A 206
LEU A 216
 None
 1.18A 2oipD-3rhtA:
undetectable		 2oipD-3rhtA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 12 ALA A 202
LEU A 248
LEU A  82
SER A 206
LEU A 216
 None
 1.10A 2oipE-3rhtA:
undetectable		 2oipE-3rhtA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 12 GLN A 161
PHE A 204
ALA A 203
THR A 162
GLY A 194
 None
 1.40A 3aobC-3rhtA:
undetectable		 3aobC-3rhtA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 12 ALA A 202
LEU A 248
LEU A  82
SER A 206
LEU A 216
 None
 1.18A 3hj3A-3rhtA:
undetectable		 3hj3A-3rhtA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 12 ALA A 202
LEU A 248
LEU A  82
PHE A 204
LEU A 216
 None
 1.17A 3hj3C-3rhtA:
undetectable		 3hj3C-3rhtA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 12 ALA A 202
LEU A 248
LEU A  82
SER A 206
LEU A 216
 None
 1.15A 3hj3C-3rhtA:
undetectable		 3hj3C-3rhtA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		4 / 6 GLU A 195
PRO A 134
ARG A 200
GLY A 194
 None
 1.50A 3oxvA-3rhtA:
undetectable		 3oxvA-3rhtA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 12 GLY A  83
ASN A 152
LEU A  79
GLY A  90
ASP A 113
 None
 1.00A 4dc3A-3rhtA:
3.0		 4dc3A-3rhtA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 12 ALA A 202
LEU A 248
LEU A  82
SER A 206
LEU A 216
 None
 1.20A 4q0dC-3rhtA:
undetectable		 4q0dC-3rhtA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 12 ALA A 202
LEU A 248
LEU A  82
SER A 206
LEU A 216
 None
 1.20A 4q0dD-3rhtA:
undetectable		 4q0dD-3rhtA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 11 LEU A 190
PHE A 204
ASP A 207
ILE A  52
ASP A   9
 None
None
CA  A 257 ( 2.1A)
None
CA  A 257 (-3.2A)
 1.40A 4uuuA-3rhtA:
undetectable
4uuuB-3rhtA:
undetectable		 4uuuA-3rhtA:
22.81
4uuuB-3rhtA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 12 ILE A  52
LEU A 248
ASP A 207
VAL A 208
ALA A 209
 None
None
CA  A 257 ( 2.1A)
None
CA  A 257 ( 4.5A)
 0.78A 5km9B-3rhtA:
undetectable		 5km9B-3rhtA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		5 / 12 LEU A 191
LEU A  82
MET A  81
ILE A 108
LEU A 104
 None
 1.21A 5toaB-3rhtA:
undetectable		 5toaB-3rhtA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 3rht (GATASE1)-LIKE
PROTEIN
(Planctopirus
limnophila) 		4 / 6 TRP A  95
HIS A  89
ASN A 152
TYR A  88
 None
 1.44A 6gneA-3rhtA:
2.6		 6gneA-3rhtA:
19.81