SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ri5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
5 / 12 ASN K  36
GLY K  48
VAL K  60
GLN K   6
LEU K  20
None
1.23A 1nhzA-3ri5K:
undetectable
1nhzA-3ri5K:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 VAL K 108
ARG K  63
VAL K  18
GLU K  85
None
1.21A 1zzrA-3ri5K:
undetectable
1zzrB-3ri5K:
undetectable
1zzrA-3ri5K:
19.60
1zzrB-3ri5K:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 GLU K  85
VAL K 108
ARG K  63
VAL K  18
None
1.21A 1zzrA-3ri5K:
undetectable
1zzrB-3ri5K:
undetectable
1zzrA-3ri5K:
19.60
1zzrB-3ri5K:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 VAL K 108
ARG K  63
VAL K  18
GLU K  85
None
1.20A 1zzuA-3ri5K:
undetectable
1zzuB-3ri5K:
undetectable
1zzuA-3ri5K:
19.60
1zzuB-3ri5K:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 GLU K  85
VAL K 108
ARG K  63
VAL K  18
None
1.20A 1zzuA-3ri5K:
undetectable
1zzuB-3ri5K:
undetectable
1zzuA-3ri5K:
19.60
1zzuB-3ri5K:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 LEU K 135
ALA K 133
LEU K 181
THR K 184
None
1.02A 3cfqA-3ri5K:
undetectable
3cfqB-3ri5K:
undetectable
3cfqA-3ri5K:
21.53
3cfqB-3ri5K:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 VAL K 108
ARG K  63
VAL K  18
GLU K  85
None
1.25A 3dqrA-3ri5K:
undetectable
3dqrB-3ri5K:
undetectable
3dqrA-3ri5K:
19.19
3dqrB-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 GLU K  85
VAL K 108
ARG K  63
VAL K  18
None
1.29A 3dqrA-3ri5K:
undetectable
3dqrB-3ri5K:
undetectable
3dqrA-3ri5K:
19.19
3dqrB-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 VAL K 108
ARG K  63
VAL K  18
GLU K  85
None
1.15A 3jx2A-3ri5K:
undetectable
3jx2B-3ri5K:
undetectable
3jx2A-3ri5K:
19.19
3jx2B-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 GLU K  85
VAL K 108
ARG K  63
VAL K  18
None
1.21A 3jx2A-3ri5K:
undetectable
3jx2B-3ri5K:
undetectable
3jx2A-3ri5K:
19.19
3jx2B-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 VAL K 108
ARG K  63
VAL K  18
GLU K  85
None
1.20A 3jx3A-3ri5K:
undetectable
3jx3B-3ri5K:
undetectable
3jx3A-3ri5K:
19.19
3jx3B-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 GLU K  85
VAL K 108
ARG K  63
VAL K  18
None
1.18A 3jx3A-3ri5K:
undetectable
3jx3B-3ri5K:
undetectable
3jx3A-3ri5K:
19.19
3jx3B-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 GLU K  85
VAL K 108
ARG K  63
VAL K  18
None
1.25A 3jx4A-3ri5K:
undetectable
3jx4B-3ri5K:
undetectable
3jx4A-3ri5K:
19.19
3jx4B-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 VAL K 108
ARG K  63
VAL K  18
GLU K  85
None
1.18A 3jx5A-3ri5K:
undetectable
3jx5B-3ri5K:
undetectable
3jx5A-3ri5K:
19.19
3jx5B-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 VAL K 108
ARG K  63
VAL K  18
GLU K  85
None
1.14A 3jx6A-3ri5K:
undetectable
3jx6B-3ri5K:
undetectable
3jx6A-3ri5K:
19.19
3jx6B-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 GLU K  85
VAL K 108
ARG K  63
VAL K  18
None
1.20A 3jx6A-3ri5K:
undetectable
3jx6B-3ri5K:
undetectable
3jx6A-3ri5K:
19.19
3jx6B-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 VAL K 108
ARG K  63
VAL K  18
GLU K  85
None
1.15A 3nljA-3ri5K:
undetectable
3nljB-3ri5K:
undetectable
3nljA-3ri5K:
19.19
3nljB-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 GLU K  85
VAL K 108
ARG K  63
VAL K  18
None
1.18A 3nljA-3ri5K:
undetectable
3nljB-3ri5K:
undetectable
3nljA-3ri5K:
19.19
3nljB-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 VAL K 108
ARG K  63
VAL K  18
GLU K  85
None
1.17A 3nlpA-3ri5K:
undetectable
3nlpB-3ri5K:
undetectable
3nlpA-3ri5K:
19.19
3nlpB-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 GLU K  85
VAL K 108
ARG K  63
VAL K  18
None
1.21A 3nlpA-3ri5K:
undetectable
3nlpB-3ri5K:
undetectable
3nlpA-3ri5K:
19.19
3nlpB-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 8 VAL K 108
ARG K  63
VAL K  18
GLU K  85
None
1.15A 3nlqA-3ri5K:
undetectable
3nlqB-3ri5K:
undetectable
3nlqA-3ri5K:
19.19
3nlqB-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 VAL K 108
ARG K  63
VAL K  18
GLU K  85
None
1.17A 3nlrA-3ri5K:
undetectable
3nlrB-3ri5K:
undetectable
3nlrA-3ri5K:
19.19
3nlrB-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 8 GLN K   6
PHE K 100
GLY K 101
GLY K  51
None
0.89A 3v3nB-3ri5K:
undetectable
3v3nB-3ri5K:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 8 GLN K   6
PHE K 100
GLY K 101
GLY K  51
None
0.89A 3v3nC-3ri5K:
undetectable
3v3nC-3ri5K:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 VAL K 108
ARG K  63
VAL K  18
GLU K  85
None
1.21A 4cx3A-3ri5K:
undetectable
4cx3B-3ri5K:
undetectable
4cx3A-3ri5K:
19.19
4cx3B-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 GLU K  85
VAL K 108
ARG K  63
VAL K  18
None
1.20A 4cx3A-3ri5K:
undetectable
4cx3B-3ri5K:
undetectable
4cx3A-3ri5K:
19.19
4cx3B-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 VAL K 108
ARG K  63
VAL K  18
GLU K  85
None
1.21A 4cx4A-3ri5K:
undetectable
4cx4B-3ri5K:
undetectable
4cx4A-3ri5K:
19.19
4cx4B-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 GLU K  85
VAL K 108
ARG K  63
VAL K  18
None
1.20A 4cx4A-3ri5K:
undetectable
4cx4B-3ri5K:
undetectable
4cx4A-3ri5K:
19.19
4cx4B-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
3 / 3 GLN K 166
THR K 165
THR K 164
None
0.74A 4fu9A-3ri5K:
undetectable
4fu9A-3ri5K:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
3 / 3 GLN K 166
THR K 165
THR K 164
None
0.76A 4fufA-3ri5K:
undetectable
4fufA-3ri5K:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 6 LEU K 135
ALA K 133
LEU K 181
THR K 184
None
1.07A 4i89A-3ri5K:
undetectable
4i89A-3ri5K:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
3 / 3 ALA K  91
TRP K  98
VAL K  99
None
0.30A 4w9nC-3ri5K:
undetectable
4w9nC-3ri5K:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 GLU K  85
VAL K 108
ARG K  63
VAL K  18
None
1.18A 5addA-3ri5K:
undetectable
5addB-3ri5K:
undetectable
5addA-3ri5K:
19.19
5addB-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 6 LEU K 135
ALA K 133
LEU K 181
THR K 184
None
1.05A 5bojA-3ri5K:
3.8
5bojA-3ri5K:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 7 VAL K 108
ARG K  63
VAL K  18
GLU K  85
None
1.21A 5g0pA-3ri5K:
undetectable
5g0pB-3ri5K:
undetectable
5g0pA-3ri5K:
19.19
5g0pB-3ri5K:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
4 / 6 LEU K 135
ALA K 133
LEU K 181
THR K 184
None
1.02A 5l4iA-3ri5K:
undetectable
5l4iA-3ri5K:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus
musculus)
5 / 12 LEU K 106
GLU K  16
VAL K  18
GLU K 201
HIS K 200
None
1.21A 5xiqD-3ri5K:
undetectable
5xiqD-3ri5K:
16.97