SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ri6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 4 LEU A 147
PRO A 176
LEU A  94
ARG A  96
 None
 1.37A 1hrkB-3ri6A:
2.5		 1hrkB-3ri6A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		5 / 7 SER A 213
LEU A 267
GLY A 271
THR A 274
ILE A 392
 None
 1.49A 2bdmA-3ri6A:
undetectable		 2bdmA-3ri6A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 8 ALA A 243
PHE A 244
ALA A 248
LEU A 218
 None
 0.91A 2bxmA-3ri6A:
undetectable		 2bxmA-3ri6A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		5 / 12 LEU A 307
ASN A 303
THR A 328
LEU A 327
ALA A 290
 None
 1.04A 2egvA-3ri6A:
undetectable		 2egvA-3ri6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		5 / 12 LEU A 307
ASN A 303
THR A 328
LEU A 327
ALA A 290
 None
 1.05A 2egvB-3ri6A:
undetectable		 2egvB-3ri6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 4 LEU A 147
PRO A 176
LEU A  94
ARG A  96
 None
 1.35A 2hrcA-3ri6A:
undetectable		 2hrcA-3ri6A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 4 LEU A 147
PRO A 176
LEU A  94
ARG A  96
 None
 1.39A 2hrcB-3ri6A:
2.5		 2hrcB-3ri6A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		5 / 12 LEU A  68
GLY A  73
ALA A  74
VAL A 217
VAL A  77
 None
 0.98A 2nnkA-3ri6A:
undetectable		 2nnkA-3ri6A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 4 LEU A 147
PRO A 176
LEU A  94
ARG A  96
 None
 1.32A 2pnjB-3ri6A:
2.5		 2pnjB-3ri6A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 4 LEU A 147
PRO A 176
LEU A  94
ARG A  96
 None
 1.35A 3hcoB-3ri6A:
undetectable		 3hcoB-3ri6A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 5 GLU A  65
LEU A  80
GLN A 268
GLY A 216
 None
 1.19A 3pp1A-3ri6A:
undetectable		 3pp1A-3ri6A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 6 SER A 100
VAL A 170
THR A 103
THR A 104
 None
 1.02A 3tneA-3ri6A:
undetectable		 3tneA-3ri6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 8 LEU A  94
VAL A 252
TRP A 226
LEU A 229
 None
 1.09A 3v81A-3ri6A:
undetectable		 3v81A-3ri6A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		3 / 3 ASP A 180
ASN A 155
SER A 203
 None
 0.74A 4obwA-3ri6A:
3.0		 4obwA-3ri6A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 6 VAL A 200
LEU A 114
ILE A  91
ALA A  90
 None
 0.79A 4zf8A-3ri6A:
undetectable		 4zf8A-3ri6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 4 VAL A  61
ALA A 265
ASN A 264
GLN A 268
 None
 1.26A 4zgfA-3ri6A:
undetectable		 4zgfA-3ri6A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 8 TYR A 187
THR A 274
ARG A 281
ILE A 392
 None
 1.14A 5jhdE-3ri6A:
undetectable
5jhdG-3ri6A:
undetectable		 5jhdE-3ri6A:
19.53
5jhdG-3ri6A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 8 LEU A  64
VAL A 217
LEU A  71
ILE A 219
 None
 0.99A 5v0vA-3ri6A:
undetectable		 5v0vA-3ri6A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 7 HIS A 263
ASP A  63
THR A  60
LEU A  68
 None
 1.18A 5x1bA-3ri6A:
undetectable
5x1bC-3ri6A:
undetectable
5x1bP-3ri6A:
undetectable		 5x1bA-3ri6A:
21.43
5x1bC-3ri6A:
21.61
5x1bP-3ri6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 5 GLN A 268
THR A 204
THR A 181
LEU A  68
 None
 1.23A 6aphA-3ri6A:
undetectable		 6aphA-3ri6A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		5 / 12 LEU A  94
VAL A 252
PRO A 234
TRP A 226
LEU A 232
 None
 1.39A 6eliA-3ri6A:
undetectable		 6eliA-3ri6A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 4 GLN A 268
THR A 204
THR A 181
LEU A  68
 None
 1.22A 6f3mA-3ri6A:
2.2		 6f3mA-3ri6A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 4 GLN A 268
THR A 204
THR A 181
LEU A  68
 None
 1.22A 6f3mC-3ri6A:
2.8		 6f3mC-3ri6A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 5 GLN A 268
THR A 204
THR A 181
LEU A  68
 None
 1.24A 6gbnB-3ri6A:
undetectable		 6gbnB-3ri6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 8 HIS A 171
LYS A 173
GLY A 174
LEU A 147
 None
 0.82A 6mdqA-3ri6A:
undetectable		 6mdqA-3ri6A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE
(Wolinella
succinogenes) 		4 / 7 HIS A 263
ASP A  63
THR A  60
LEU A  68
 None
 1.10A 6nmfA-3ri6A:
undetectable
6nmfC-3ri6A:
undetectable
6nmfP-3ri6A:
undetectable		 6nmfA-3ri6A:
21.43
6nmfC-3ri6A:
21.61
6nmfP-3ri6A:
21.61