SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ria'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 3ria MOUSE MONOCLONAL FAB
FRAGMENT, HEAVY
CHAIN
(Mus
musculus) 		4 / 4 THR F 125
PRO F 127
THR F 126
PRO F 156
 None
 1.27A 1dsdC-3riaF:
undetectable		 1dsdC-3riaF:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 3ria MOUSE MONOCLONAL FAB
FRAGMENT, HEAVY
CHAIN
(Mus
musculus) 		4 / 4 THR F 126
PRO F 156
THR F 125
PRO F 127
 None
 1.20A 1dsdC-3riaF:
undetectable		 1dsdC-3riaF:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 3ria MOUSE MONOCLONAL FAB
FRAGMENT, HEAVY
CHAIN
(Mus
musculus) 		4 / 4 THR F 125
PRO F 127
THR F 126
PRO F 156
 None
 1.27A 1dsdC-3riaF:
undetectable		 1dsdC-3riaF:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 3ria MOUSE MONOCLONAL FAB
FRAGMENT, HEAVY
CHAIN
(Mus
musculus) 		4 / 4 THR F 126
PRO F 156
THR F 125
PRO F 127
 None
 1.20A 1dsdC-3riaF:
undetectable		 1dsdC-3riaF:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 3ria MOUSE MONOCLONAL FAB
FRAGMENT, HEAVY
CHAIN
(Mus
musculus) 		3 / 3 ASP F  90
LEU F  84
LEU F  86
 None
 0.53A 1ikeA-3riaF:
undetectable		 1ikeA-3riaF:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 3ria MOUSE MONOCLONAL FAB
FRAGMENT, HEAVY
CHAIN
(Mus
musculus) 		3 / 3 ASP F  90
LEU F  84
LEU F  86
 None
 0.50A 1np1B-3riaF:
undetectable		 1np1B-3riaF:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 3ria MOUSE MONOCLONAL FAB
FRAGMENT, HEAVY
CHAIN
(Mus
musculus) 		3 / 3 TYR F 184
GLY F 153
PHE F 155
 None
 0.71A 2m2pB-3riaF:
undetectable		 2m2pB-3riaF:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ria MOUSE MONOCLONAL FAB
FRAGMENT, HEAVY
CHAIN
(Mus
musculus) 		3 / 3 THR F 119
GLU F 157
HIS F 208
 None
 0.76A 3g1uB-3riaF:
undetectable		 3g1uB-3riaF:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 3ria MOUSE MONOCLONAL FAB
FRAGMENT, HEAVY
CHAIN
(Mus
musculus) 		4 / 5 VAL F   2
TYR F  27
ARG F  98
TYR F 111
 None
 0.41A 4m7kH-3riaF:
23.2		 4m7kH-3riaF:
66.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3ria MOUSE MONOCLONAL FAB
FRAGMENT, HEAVY
CHAIN
(Mus
musculus) 		3 / 3 SER F 212
ALA F 207
VAL F 206
 None
 0.56A 4x1iA-3riaF:
undetectable		 4x1iA-3riaF:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3ria MOUSE MONOCLONAL FAB
FRAGMENT, HEAVY
CHAIN
(Mus
musculus) 		3 / 3 SER F 212
ALA F 207
VAL F 206
 None
 0.52A 5eypA-3riaF:
undetectable		 5eypA-3riaF:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 3ria MOUSE MONOCLONAL FAB
FRAGMENT, HEAVY
CHAIN
(Mus
musculus) 		3 / 3 SER F 212
ALA F 207
VAL F 206
 None
 0.54A 5xiwC-3riaF:
undetectable		 5xiwC-3riaF:
16.18