SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rih'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3rih SHORT CHAIN
DEHYDROGENASE OR
REDUCTASE
(Mycobacteroides
abscessus) 		5 / 12 TYR A 170
THR A 154
ALA A 175
SER A 173
GLY A 201
 PG5  A 273 ( 3.9A)
EDO  A 279 ( 4.7A)
EDO  A 274 ( 3.7A)
None
None
 1.28A 1nbiC-3rihA:
6.8		 1nbiC-3rihA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3rih SHORT CHAIN
DEHYDROGENASE OR
REDUCTASE
(Mycobacteroides
abscessus) 		5 / 12 TYR A 170
THR A 154
ALA A 175
SER A 173
GLY A 201
 PG5  A 273 ( 3.9A)
EDO  A 279 ( 4.7A)
EDO  A 274 ( 3.7A)
None
None
 1.27A 1nbiD-3rihA:
6.9		 1nbiD-3rihA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 3rih SHORT CHAIN
DEHYDROGENASE OR
REDUCTASE
(Mycobacteroides
abscessus) 		5 / 12 GLN A 177
THR A 132
LEU A 199
GLN A 252
LEU A 178
 None
None
None
None
EDO  A 274 ( 4.1A)
 1.35A 3fsuA-3rihA:
1.8		 3fsuA-3rihA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 3rih SHORT CHAIN
DEHYDROGENASE OR
REDUCTASE
(Mycobacteroides
abscessus) 		5 / 11 ILE A  35
ILE A  31
GLY A  30
VAL A 256
GLY A 229
 None
 0.91A 4ac9B-3rihA:
6.6
4ac9C-3rihA:
6.4		 4ac9B-3rihA:
22.29
4ac9C-3rihA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3rih SHORT CHAIN
DEHYDROGENASE OR
REDUCTASE
(Mycobacteroides
abscessus) 		5 / 9 ALA A  87
THR A  90
ALA A  88
GLY A  73
ALA A  49
 None
None
EDO  A 276 ( 4.0A)
None
None
 1.22A 4qvnK-3rihA:
undetectable
4qvnL-3rihA:
undetectable		 4qvnK-3rihA:
22.67
4qvnL-3rihA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3rih SHORT CHAIN
DEHYDROGENASE OR
REDUCTASE
(Mycobacteroides
abscessus) 		5 / 9 ALA A  87
THR A  90
ALA A  88
GLY A  73
ALA A  49
 None
None
EDO  A 276 ( 4.0A)
None
None
 1.22A 4qvnY-3rihA:
undetectable
4qvnZ-3rihA:
undetectable		 4qvnY-3rihA:
22.67
4qvnZ-3rihA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3rih SHORT CHAIN
DEHYDROGENASE OR
REDUCTASE
(Mycobacteroides
abscessus) 		3 / 3 SER A  21
ALA A  47
VAL A  48
 None
 0.61A 4x1iA-3rihA:
6.0		 4x1iA-3rihA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3rih SHORT CHAIN
DEHYDROGENASE OR
REDUCTASE
(Mycobacteroides
abscessus) 		4 / 8 ILE A 107
GLY A 131
THR A 135
LEU A  76
 None
 0.92A 5esjA-3rihA:
undetectable		 5esjA-3rihA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3rih SHORT CHAIN
DEHYDROGENASE OR
REDUCTASE
(Mycobacteroides
abscessus) 		4 / 7 ILE A 107
GLY A 131
THR A 135
LEU A  76
 None
 0.97A 5esmA-3rihA:
undetectable		 5esmA-3rihA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 3rih SHORT CHAIN
DEHYDROGENASE OR
REDUCTASE
(Mycobacteroides
abscessus) 		4 / 7 ILE A  31
THR A 158
ILE A 157
SER A 156
 None
PG5  A 273 ( 4.2A)
None
PG5  A 273 ( 4.9A)
 0.78A 5fukA-3rihA:
undetectable
5fukB-3rihA:
undetectable		 5fukA-3rihA:
24.21
5fukB-3rihA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 3rih SHORT CHAIN
DEHYDROGENASE OR
REDUCTASE
(Mycobacteroides
abscessus) 		4 / 8 ALA A 176
SER A 156
THR A 154
GLY A 171
 None
PG5  A 273 ( 4.9A)
EDO  A 279 ( 4.7A)
None
 0.85A 5v0vA-3rihA:
undetectable		 5v0vA-3rihA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 3rih SHORT CHAIN
DEHYDROGENASE OR
REDUCTASE
(Mycobacteroides
abscessus) 		4 / 6 GLN A 137
VAL A  78
LEU A 188
ARG A 150
 EDO  A 278 (-3.8A)
None
None
None
 1.33A 6brdB-3rihA:
undetectable		 6brdB-3rihA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 3rih SHORT CHAIN
DEHYDROGENASE OR
REDUCTASE
(Mycobacteroides
abscessus) 		4 / 5 LEU A  76
THR A  25
THR A  28
GLY A  26
 None
 1.13A 6gtqA-3rihA:
undetectable		 6gtqA-3rihA:
21.72