SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rim'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.38A 1c9sB-3rimA:
undetectable
1c9sC-3rimA:
undetectable		 1c9sB-3rimA:
7.83
1c9sC-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 1c9sC-3rimA:
undetectable
1c9sD-3rimA:
undetectable		 1c9sC-3rimA:
7.83
1c9sD-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 1c9sF-3rimA:
undetectable
1c9sG-3rimA:
undetectable		 1c9sF-3rimA:
7.83
1c9sG-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 668
ILE A 667
ARG A 522
 None
 0.71A 1cd2A-3rimA:
undetectable		 1cd2A-3rimA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		3 / 3 PHE A 262
LEU A 200
SER A 189
 None
 0.91A 1e7aA-3rimA:
undetectable		 1e7aA-3rimA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 155
HIS A 454
PRO A 456
ALA A 148
GLY A 144
 None
 1.42A 1mjqC-3rimA:
undetectable
1mjqD-3rimA:
undetectable		 1mjqC-3rimA:
9.16
1mjqD-3rimA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 8 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.93A 1o76B-3rimA:
undetectable		 1o76B-3rimA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 331
PHE A 167
TRP A 338
 None
 1.40A 1r15C-3rimA:
undetectable		 1r15C-3rimA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 331
PHE A 167
TRP A 338
 None
 1.39A 1r15F-3rimA:
undetectable		 1r15F-3rimA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 331
PHE A 167
TRP A 338
 None
 1.40A 1r15G-3rimA:
undetectable		 1r15G-3rimA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 331
PHE A 167
TRP A 338
 None
 1.39A 1r15H-3rimA:
undetectable		 1r15H-3rimA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 536
ARG A 458
TRP A 623
LEU A 548
 None
 1.43A 1s8fA-3rimA:
2.2
1s8fB-3rimA:
2.2		 1s8fA-3rimA:
14.11
1s8fB-3rimA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_A_BEZA306_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 353
GLY A 455
PRO A 456
HIS A 169
HIS A 454
 None
 1.32A 1s9aA-3rimA:
undetectable		 1s9aA-3rimA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.91A 1t85A-3rimA:
undetectable		 1t85A-3rimA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.93A 1t87A-3rimA:
undetectable		 1t87A-3rimA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.89A 1t87B-3rimA:
undetectable		 1t87B-3rimA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.37A 1utdA-3rimA:
undetectable
1utdB-3rimA:
undetectable		 1utdA-3rimA:
7.83
1utdB-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.38A 1utdD-3rimA:
undetectable
1utdE-3rimA:
undetectable		 1utdD-3rimA:
7.83
1utdE-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 8 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.86A 1uyuA-3rimA:
undetectable		 1uyuA-3rimA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 8 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.88A 1uyuB-3rimA:
undetectable		 1uyuB-3rimA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.83A 1yrcA-3rimA:
undetectable		 1yrcA-3rimA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.85A 1yrdA-3rimA:
undetectable		 1yrdA-3rimA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 6 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.83A 2feuA-3rimA:
undetectable		 2feuA-3rimA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.85A 2feuB-3rimA:
undetectable		 2feuB-3rimA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 140
GLY A 138
GLY A 133
VAL A  80
SER A 189
 None
 1.08A 2okcA-3rimA:
undetectable		 2okcA-3rimA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 140
GLY A 138
GLY A 133
VAL A  80
SER A 189
 None
 1.08A 2okcB-3rimA:
2.4		 2okcB-3rimA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 5 ILE A  92
LEU A  33
ASP A  28
PHE A 301
 None
 1.06A 2opxA-3rimA:
undetectable		 2opxA-3rimA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 6 SER A 165
PHE A 167
ASP A 168
GLU A 342
 None
 0.67A 2vn1B-3rimA:
undetectable		 2vn1B-3rimA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 6 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.87A 2zuiA-3rimA:
undetectable		 2zuiA-3rimA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.84A 2zwtA-3rimA:
undetectable		 2zwtA-3rimA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.84A 2zwuA-3rimA:
undetectable		 2zwuA-3rimA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 478
LEU A 477
MET A 481
ILE A 171
 None
 0.90A 3cldB-3rimA:
undetectable		 3cldB-3rimA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 ARG A 150
ILE A 130
GLY A 450
ILE A 451
ILE A 171
 None
 1.11A 3ekqB-3rimA:
undetectable		 3ekqB-3rimA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 ARG A 150
ILE A 130
GLY A 450
ILE A 451
ILE A 171
 None
 1.26A 3ekyB-3rimA:
undetectable		 3ekyB-3rimA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 680
TRP A 654
VAL A 520
ILE A 549
THR A 592
 None
 1.18A 3em0B-3rimA:
undetectable		 3em0B-3rimA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.84A 3fwfA-3rimA:
undetectable		 3fwfA-3rimA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.83A 3fwfB-3rimA:
undetectable		 3fwfB-3rimA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.86A 3fwiA-3rimA:
undetectable		 3fwiA-3rimA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.85A 3fwjA-3rimA:
undetectable		 3fwjA-3rimA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 349
GLY A 455
PRO A 456
HIS A 169
HIS A 454
 None
 1.37A 3hgiA-3rimA:
undetectable		 3hgiA-3rimA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 353
GLY A 455
PRO A 456
HIS A 169
HIS A 454
 None
 1.20A 3hgiA-3rimA:
undetectable		 3hgiA-3rimA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 207
PRO A 117
GLY A  84
ASP A 205
ILE A 174
 MG  A1001 ( 2.6A)
None
None
None
None
 1.30A 3iv6A-3rimA:
2.5		 3iv6A-3rimA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 647
GLY A 570
ARG A 513
GLY A 547
ASN A 541
 None
 1.17A 3jzjA-3rimA:
undetectable		 3jzjA-3rimA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.83A 3l63A-3rimA:
undetectable		 3l63A-3rimA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 461
ILE A 515
GLY A 547
ALA A 478
ALA A 479
 None
 0.83A 3sudC-3rimA:
undetectable		 3sudC-3rimA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 461
ILE A 515
GLY A 547
ALA A 478
ALA A 479
 None
 0.85A 3sueA-3rimA:
undetectable		 3sueA-3rimA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 461
ILE A 515
GLY A 547
ALA A 478
ALA A 479
 None
 0.90A 3sufB-3rimA:
undetectable		 3sufB-3rimA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 461
ILE A 515
GLY A 547
ALA A 478
ALA A 479
 None
 0.81A 3sufD-3rimA:
undetectable		 3sufD-3rimA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 548
ILE A 536
ALA A 532
ILE A 410
LEU A 388
 None
 0.99A 3vrmA-3rimA:
undetectable		 3vrmA-3rimA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 437
TRP A 533
ILE A 536
TRP A 489
 None
 1.43A 3w37A-3rimA:
0.0		 3w37A-3rimA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 447
TRP A 533
ILE A 536
TRP A 489
 None
 1.18A 3welA-3rimA:
2.5		 3welA-3rimA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.81A 3wrhA-3rimA:
undetectable		 3wrhA-3rimA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 135
GLY A 136
ILE A 174
VAL A 173
 TPP  A1002 (-3.9A)
None
None
None
 0.90A 3wriB-3rimA:
undetectable		 3wriB-3rimA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.83A 3wrjA-3rimA:
undetectable		 3wrjA-3rimA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.81A 3wrlA-3rimA:
undetectable		 3wrlA-3rimA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.82A 3wrlE-3rimA:
undetectable		 3wrlE-3rimA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.82A 3wrmA-3rimA:
undetectable		 3wrmA-3rimA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_F_CAMF503_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.83A 3wrmF-3rimA:
undetectable		 3wrmF-3rimA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 8 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.83A 4l4fA-3rimA:
undetectable		 4l4fA-3rimA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4G_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.93A 4l4gA-3rimA:
undetectable		 4l4gA-3rimA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 ARG A 681
ALA A 601
ILE A 667
HIS A 669
GLY A 671
 None
 1.13A 4l9qA-3rimA:
undetectable		 4l9qA-3rimA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 558
VAL A 600
PHE A 680
SER A 493
GLY A 649
 None
 0.98A 4q15A-3rimA:
undetectable		 4q15A-3rimA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 558
VAL A 600
PHE A 680
SER A 493
GLY A 649
 None
 0.95A 4q15B-3rimA:
3.5		 4q15B-3rimA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 120
LEU A 109
SER A  86
HIS A  45
 None
 0.80A 4qknA-3rimA:
undetectable		 4qknA-3rimA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 403
SER A 399
GLY A 398
ALA A 380
GLY A 382
 None
 1.20A 4r29A-3rimA:
undetectable		 4r29A-3rimA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 403
SER A 399
GLY A 398
ALA A 380
GLY A 382
 None
 1.16A 4r29B-3rimA:
undetectable		 4r29B-3rimA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 403
SER A 399
GLY A 398
ALA A 380
GLY A 382
 None
 1.20A 4r29C-3rimA:
undetectable		 4r29C-3rimA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A 485
GLY A 461
ALA A 188
THR A 185
ALA A 446
 None
 1.09A 4uckB-3rimA:
3.0		 4uckB-3rimA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 SER A 189
LEU A  81
LEU A 139
ALA A 175
ALA A 142
 None
 1.23A 4x1kA-3rimA:
undetectable
4x1kB-3rimA:
undetectable		 4x1kA-3rimA:
21.42
4x1kB-3rimA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 558
VAL A 600
PHE A 680
SER A 493
GLY A 649
 None
 0.95A 4ydqA-3rimA:
undetectable		 4ydqA-3rimA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 ASP A 177
HIS A  85
LEU A  52
THR A  89
ALA A  49
 MG  A1001 ( 2.9A)
TPP  A1002 (-4.0A)
None
None
None
 1.24A 4yhaB-3rimA:
undetectable		 4yhaB-3rimA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 521
ARG A 458
VAL A 488
TRP A 533
 None
 1.35A 5adeA-3rimA:
undetectable
5adeB-3rimA:
undetectable		 5adeA-3rimA:
19.97
5adeB-3rimA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eeuA-3rimA:
undetectable
5eeuB-3rimA:
undetectable		 5eeuA-3rimA:
7.83
5eeuB-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5eeuB-3rimA:
undetectable
5eeuC-3rimA:
undetectable		 5eeuB-3rimA:
7.83
5eeuC-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eeuD-3rimA:
undetectable
5eeuE-3rimA:
undetectable		 5eeuD-3rimA:
7.83
5eeuE-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.35A 5eeuE-3rimA:
undetectable
5eeuF-3rimA:
undetectable		 5eeuE-3rimA:
7.83
5eeuF-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eeuH-3rimA:
undetectable
5eeuI-3rimA:
undetectable		 5eeuH-3rimA:
7.83
5eeuI-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eeuJ-3rimA:
undetectable
5eeuK-3rimA:
undetectable		 5eeuJ-3rimA:
7.83
5eeuK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5eeuA-3rimA:
undetectable
5eeuK-3rimA:
undetectable		 5eeuA-3rimA:
7.83
5eeuK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.38A 5eevB-3rimA:
undetectable
5eevC-3rimA:
undetectable		 5eevB-3rimA:
7.83
5eevC-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eevD-3rimA:
undetectable
5eevE-3rimA:
undetectable		 5eevD-3rimA:
7.83
5eevE-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.35A 5eevE-3rimA:
undetectable
5eevF-3rimA:
undetectable		 5eevE-3rimA:
7.83
5eevF-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eevH-3rimA:
undetectable
5eevI-3rimA:
undetectable		 5eevH-3rimA:
7.83
5eevI-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eevJ-3rimA:
undetectable
5eevK-3rimA:
undetectable		 5eevJ-3rimA:
7.83
5eevK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5eevA-3rimA:
undetectable
5eevK-3rimA:
undetectable		 5eevA-3rimA:
7.83
5eevK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5eewB-3rimA:
undetectable
5eewC-3rimA:
undetectable		 5eewB-3rimA:
7.83
5eewC-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eewD-3rimA:
undetectable
5eewE-3rimA:
undetectable		 5eewD-3rimA:
7.83
5eewE-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.35A 5eewE-3rimA:
undetectable
5eewF-3rimA:
undetectable		 5eewE-3rimA:
7.83
5eewF-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5eewH-3rimA:
undetectable
5eewI-3rimA:
undetectable		 5eewH-3rimA:
7.83
5eewI-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eewJ-3rimA:
undetectable
5eewK-3rimA:
undetectable		 5eewJ-3rimA:
7.83
5eewK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5eewA-3rimA:
undetectable
5eewK-3rimA:
undetectable		 5eewA-3rimA:
7.83
5eewK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.38A 5eexB-3rimA:
undetectable
5eexC-3rimA:
undetectable		 5eexB-3rimA:
7.83
5eexC-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eexD-3rimA:
undetectable
5eexE-3rimA:
undetectable		 5eexD-3rimA:
7.83
5eexE-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.35A 5eexE-3rimA:
undetectable
5eexF-3rimA:
undetectable		 5eexE-3rimA:
7.83
5eexF-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5eexH-3rimA:
undetectable
5eexI-3rimA:
undetectable		 5eexH-3rimA:
7.83
5eexI-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eexJ-3rimA:
undetectable
5eexK-3rimA:
undetectable		 5eexJ-3rimA:
7.83
5eexK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5eexA-3rimA:
undetectable
5eexK-3rimA:
undetectable		 5eexA-3rimA:
7.83
5eexK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.40A 5eexQ-3rimA:
undetectable
5eexR-3rimA:
undetectable		 5eexQ-3rimA:
7.83
5eexR-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5eeyB-3rimA:
undetectable
5eeyC-3rimA:
undetectable		 5eeyB-3rimA:
7.83
5eeyC-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eeyD-3rimA:
undetectable
5eeyE-3rimA:
undetectable		 5eeyD-3rimA:
7.83
5eeyE-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.35A 5eeyE-3rimA:
undetectable
5eeyF-3rimA:
undetectable		 5eeyE-3rimA:
7.83
5eeyF-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5eeyH-3rimA:
undetectable
5eeyI-3rimA:
undetectable		 5eeyH-3rimA:
7.83
5eeyI-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eeyJ-3rimA:
undetectable
5eeyK-3rimA:
undetectable		 5eeyJ-3rimA:
7.83
5eeyK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5eeyA-3rimA:
undetectable
5eeyK-3rimA:
undetectable		 5eeyA-3rimA:
7.83
5eeyK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5eezB-3rimA:
undetectable
5eezC-3rimA:
undetectable		 5eezB-3rimA:
7.83
5eezC-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eezD-3rimA:
undetectable
5eezE-3rimA:
undetectable		 5eezD-3rimA:
7.83
5eezE-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5eezH-3rimA:
undetectable
5eezI-3rimA:
undetectable		 5eezH-3rimA:
7.83
5eezI-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5eezJ-3rimA:
undetectable
5eezK-3rimA:
undetectable		 5eezJ-3rimA:
7.83
5eezK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5eezA-3rimA:
undetectable
5eezK-3rimA:
undetectable		 5eezA-3rimA:
7.83
5eezK-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5ef0B-3rimA:
undetectable
5ef0C-3rimA:
undetectable		 5ef0B-3rimA:
7.83
5ef0C-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5ef0D-3rimA:
undetectable
5ef0E-3rimA:
undetectable		 5ef0D-3rimA:
7.83
5ef0E-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5ef0H-3rimA:
undetectable
5ef0I-3rimA:
undetectable		 5ef0H-3rimA:
7.83
5ef0I-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5ef0J-3rimA:
undetectable
5ef0K-3rimA:
undetectable		 5ef0J-3rimA:
7.83
5ef0K-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5ef0A-3rimA:
undetectable
5ef0K-3rimA:
undetectable		 5ef0A-3rimA:
7.83
5ef0K-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5ef1B-3rimA:
undetectable
5ef1C-3rimA:
undetectable		 5ef1B-3rimA:
7.83
5ef1C-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5ef1D-3rimA:
undetectable
5ef1E-3rimA:
undetectable		 5ef1D-3rimA:
7.83
5ef1E-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5ef1H-3rimA:
undetectable
5ef1I-3rimA:
undetectable		 5ef1H-3rimA:
7.83
5ef1I-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5ef1J-3rimA:
undetectable
5ef1K-3rimA:
undetectable		 5ef1J-3rimA:
7.83
5ef1K-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5ef1A-3rimA:
undetectable
5ef1K-3rimA:
undetectable		 5ef1A-3rimA:
7.83
5ef1K-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5ef2B-3rimA:
undetectable
5ef2C-3rimA:
undetectable		 5ef2B-3rimA:
7.83
5ef2C-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5ef2D-3rimA:
undetectable
5ef2E-3rimA:
undetectable		 5ef2D-3rimA:
7.83
5ef2E-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5ef2H-3rimA:
undetectable
5ef2I-3rimA:
undetectable		 5ef2H-3rimA:
7.83
5ef2I-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5ef2J-3rimA:
undetectable
5ef2K-3rimA:
undetectable		 5ef2J-3rimA:
7.83
5ef2K-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5ef2A-3rimA:
undetectable
5ef2K-3rimA:
undetectable		 5ef2A-3rimA:
7.83
5ef2K-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5ef3B-3rimA:
undetectable
5ef3C-3rimA:
undetectable		 5ef3B-3rimA:
7.83
5ef3C-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5ef3D-3rimA:
undetectable
5ef3E-3rimA:
undetectable		 5ef3D-3rimA:
7.83
5ef3E-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.37A 5ef3H-3rimA:
undetectable
5ef3I-3rimA:
undetectable		 5ef3H-3rimA:
7.83
5ef3I-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 9 SER A 176
GLY A  47
HIS A  45
THR A  48
ILE A 269
 TPP  A1002 (-2.5A)
None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
 1.36A 5ef3J-3rimA:
undetectable
5ef3K-3rimA:
undetectable		 5ef3J-3rimA:
7.83
5ef3K-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  47
HIS A  45
THR A  48
ILE A 269
SER A 176
 None
None
TPP  A1002 (-2.5A)
TPP  A1002 ( 4.9A)
TPP  A1002 (-2.5A)
 1.35A 5ef3A-3rimA:
undetectable
5ef3K-3rimA:
undetectable		 5ef3A-3rimA:
7.83
5ef3K-3rimA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 123
ASP A 484
GLY A 544
ASP A 482
 None
 1.24A 5hp1A-3rimA:
undetectable		 5hp1A-3rimA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 123
GLY A 544
ASP A 482
ASP A 484
 None
 1.29A 5hp1A-3rimA:
undetectable		 5hp1A-3rimA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 625
TRP A 654
GLY A 570
ILE A 590
ALA A 591
 None
 1.13A 5j7wC-3rimA:
undetectable		 5j7wC-3rimA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 625
TRP A 654
GLY A 570
ILE A 590
ALA A 591
 None
 1.06A 5j7wD-3rimA:
undetectable		 5j7wD-3rimA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 680
ILE A 494
ALA A 651
SER A 510
ILE A 667
 None
 1.25A 5mlmA-3rimA:
undetectable		 5mlmA-3rimA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 333
ASP A 336
TRP A 338
ALA A 339
 None
 0.88A 5nwvA-3rimA:
undetectable		 5nwvA-3rimA:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 443
LEU A 448
ILE A 451
TYR A 151
PHE A 416
 None
 1.34A 5vlmE-3rimA:
undetectable		 5vlmE-3rimA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 561
LEU A 573
VAL A 600
VAL A 555
 None
 0.89A 5wk9A-3rimA:
undetectable		 5wk9A-3rimA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 7 ARG A  31
VAL A 295
PRO A 272
GLY A 270
 None
 0.98A 5x80C-3rimA:
undetectable
5x80D-3rimA:
undetectable		 5x80C-3rimA:
14.61
5x80D-3rimA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 558
VAL A 600
PHE A 680
SER A 493
GLY A 649
 None
 1.02A 5xiqA-3rimA:
undetectable		 5xiqA-3rimA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A  27
TYR A  57
GLU A 241
 None
 0.64A 5zmqD-3rimA:
undetectable
5zmqE-3rimA:
undetectable		 5zmqD-3rimA:
13.69
5zmqE-3rimA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 461
ILE A 515
GLY A 547
ALA A 478
ALA A 479
 None
 0.85A 6c2mD-3rimA:
undetectable		 6c2mD-3rimA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 245
GLU A 238
VAL A 237
LEU A 265
ILE A 263
 None
 1.02A 6ectA-3rimA:
2.6		 6ectA-3rimA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 245
GLU A 238
VAL A 237
LEU A 265
ILE A 263
 None
 0.97A 6ecxA-3rimA:
2.5		 6ecxA-3rimA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 395
LEU A 537
ARG A 458
 None
 0.67A 6fgdA-3rimA:
2.3		 6fgdA-3rimA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 6 TYR A 571
ASN A 527
TYR A 531
GLU A 369
 None
 1.17A 6gneA-3rimA:
2.8		 6gneA-3rimA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 571
ASN A 527
TYR A 531
GLU A 369
 None
 1.18A 6gneB-3rimA:
3.5		 6gneB-3rimA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 680
ILE A 494
SER A 510
TRP A 654
ILE A 667
 None
 1.24A 6gsdA-3rimA:
undetectable		 6gsdA-3rimA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 3rim TRANSKETOLASE
(Mycobacterium
tuberculosis) 		6 / 12 LEU A 385
THR A 485
ILE A 486
ALA A 403
LEU A 448
MET A 444
 None
 1.49A 6ie8A-3rimA:
undetectable		 6ie8A-3rimA:
14.51