SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rip'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		5 / 12 ILE A 356
ILE A 357
LEU A 543
ILE A 547
HIS A 560
 None
 1.09A 1bsxA-3ripA:
undetectable		 1bsxA-3ripA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		5 / 12 ILE A 356
ILE A 357
LEU A 543
ILE A 547
HIS A 560
 None
 1.09A 1bsxB-3ripA:
undetectable		 1bsxB-3ripA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		5 / 12 ALA A 400
LEU A 411
PHE A 372
LEU A 452
ALA A 395
 None
 1.05A 1bzfA-3ripA:
undetectable		 1bzfA-3ripA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		5 / 12 ALA A 400
PHE A 369
ARG A 485
PHE A 372
LEU A 452
 None
 1.06A 1drfA-3ripA:
undetectable		 1drfA-3ripA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		5 / 12 LEU A 197
GLU A 304
SER A 188
GLY A 194
GLY A 280
 None
 0.85A 1etrH-3ripA:
undetectable		 1etrH-3ripA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		5 / 12 LEU A 196
GLY A 194
VAL A 283
GLN A 186
LEU A 187
 None
 1.33A 1nhzA-3ripA:
undetectable		 1nhzA-3ripA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		3 / 3 ASP A 561
LEU A 564
HIS A 463
 None
 0.70A 1qknA-3ripA:
undetectable		 1qknA-3ripA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		4 / 5 GLY A 150
HIS A 149
ILE A 263
PHE A 203
 None
 0.97A 1xf1A-3ripA:
undetectable		 1xf1A-3ripA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		4 / 5 LEU A 104
LEU A  48
LEU A  25
LEU A 126
 None
 1.05A 1yajD-3ripA:
undetectable		 1yajD-3ripA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		4 / 7 PHE A  55
VAL A 168
VAL A 138
VAL A 139
 None
 0.97A 2qbnA-3ripA:
undetectable		 2qbnA-3ripA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		5 / 12 ALA A 400
PHE A 369
ARG A 485
PHE A 372
LEU A 452
 None
 1.11A 2w3bA-3ripA:
undetectable		 2w3bA-3ripA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		4 / 7 LEU A 192
GLU A 304
ASP A 305
SER A 188
 None
 1.01A 3dzgA-3ripA:
undetectable		 3dzgA-3ripA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		4 / 7 LEU A 192
GLU A 304
ASP A 305
SER A 188
 None
 1.05A 3dzgB-3ripA:
undetectable		 3dzgB-3ripA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		4 / 8 TYR A 267
HIS A 180
LEU A 187
MET A 191
 None
 1.40A 3uzzB-3ripA:
undetectable		 3uzzB-3ripA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		5 / 12 ILE A 613
LEU A 595
PHE A 592
LEU A 588
ILE A 512
 None
 1.02A 4pd4C-3ripA:
6.1		 4pd4C-3ripA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		4 / 7 VAL A 487
ILE A 585
ASN A 651
PHE A 579
 None
None
None
GOL  A 679 ( 4.3A)
 0.86A 5hieC-3ripA:
undetectable		 5hieC-3ripA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		5 / 12 PHE A 618
TRP A 495
LEU A 614
LEU A 595
GLN A 498
 None
 1.09A 5im2A-3ripA:
undetectable		 5im2A-3ripA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		3 / 3 HIS A 415
SER A 455
LYS A 457
 None
 0.63A 5os7A-3ripA:
undetectable		 5os7A-3ripA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		4 / 7 TYR A  52
GLN A 102
ASP A 106
TYR A  12
 None
 1.19A 5ov9B-3ripA:
2.1		 5ov9B-3ripA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		4 / 6 LEU A 462
GLN A 353
LEU A 351
LEU A 354
 None
 1.15A 5yvnA-3ripA:
2.4		 5yvnA-3ripA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4
(Homo
sapiens) 		3 / 3 HIS A 415
SER A 455
LYS A 457
 None
 0.63A 6gmdB-3ripA:
undetectable		 6gmdB-3ripA:
19.44