SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rj8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 12 GLU A 374
GLY A 186
ALA A 181
PHE A 194
ASN A 446
 None
 1.07A 1nw3A-3rj8A:
undetectable		 1nw3A-3rj8A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_A_ADNA1501_1
(CLASS B ACID
PHOSPHATASE)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 10 LEU A 155
THR A 131
GLY A 130
THR A 325
TYR A 425
 None
FAD  A 501 (-3.7A)
FAD  A 501 (-3.2A)
None
FAD  A 501 (-4.6A)
 1.34A 1rmtA-3rj8A:
undetectable		 1rmtA-3rj8A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		3 / 3 ARG A 432
TYR A 320
LYS A 322
 None
 0.88A 1uujB-3rj8A:
undetectable		 1uujB-3rj8A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		3 / 3 THR A  46
GLU A 174
HIS A 105
 None
 0.91A 1xwfB-3rj8A:
undetectable		 1xwfB-3rj8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		3 / 3 THR A  46
GLU A 174
HIS A 105
 None
 0.90A 1xwfD-3rj8A:
undetectable		 1xwfD-3rj8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		4 / 6 LEU A 450
SER A 192
ILE A 426
HIS A 143
 None
FAD  A 501 (-4.0A)
None
FAD  A 501 (-4.8A)
 0.96A 1yajF-3rj8A:
undetectable		 1yajF-3rj8A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 12 GLY A 191
SER A 192
GLY A 195
VAL A 157
ASP A 158
 None
FAD  A 501 (-4.0A)
None
None
None
 1.19A 2b25B-3rj8A:
undetectable		 2b25B-3rj8A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 12 LEU A 183
LEU A 453
GLY A 191
ASN A 193
ALA A  65
 None
None
None
None
FAD  A 501 (-3.6A)
 1.05A 2bm9B-3rj8A:
undetectable		 2bm9B-3rj8A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 12 SER A  64
LEU A 450
HIS A 143
ALA A 438
ALA A 468
 None
None
FAD  A 501 (-4.8A)
None
None
 0.99A 2bxcA-3rj8A:
undetectable		 2bxcA-3rj8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD8_0
(GRAMICIDIN D)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		4 / 4 VAL A 348
TRP A 409
VAL A 344
TRP A 353
 None
 1.47A 2izqC-3rj8A:
undetectable
2izqD-3rj8A:
undetectable		 2izqC-3rj8A:
3.76
2izqD-3rj8A:
3.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		4 / 5 LEU A 112
SER A 138
GLY A 139
HIS A  70
 None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.2A)
FAD  A 501 (-2.5A)
 1.01A 2otfA-3rj8A:
undetectable		 2otfA-3rj8A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		3 / 3 SER A 150
GLY A 145
GLY A 130
 None
FAD  A 501 ( 3.7A)
FAD  A 501 (-3.2A)
 0.56A 3bogA-3rj8A:
undetectable
3bogC-3rj8A:
undetectable		 3bogA-3rj8A:
undetectable
3bogC-3rj8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		3 / 3 GLY A  79
PRO A 431
LEU A  33
 None
 0.63A 3hcpB-3rj8A:
undetectable		 3hcpB-3rj8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 12 VAL A 245
VAL A 359
PRO A 276
ILE A 259
VAL A 233
 None
 1.23A 3iw1A-3rj8A:
undetectable		 3iw1A-3rj8A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 12 TYR A 465
SER A  71
ILE A 426
GLY A 189
ALA A 190
 FAD  A 501 ( 4.3A)
FAD  A 501 (-4.3A)
None
None
None
 1.12A 3kk6A-3rj8A:
undetectable		 3kk6A-3rj8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 12 PHE A 141
HIS A 143
GLY A 144
ALA A 110
GLY A 109
 None
FAD  A 501 (-4.8A)
None
None
None
 1.22A 3v3oA-3rj8A:
undetectable		 3v3oA-3rj8A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		4 / 7 ILE A 230
GLY A 229
PHE A 247
LEU A 277
 None
 0.90A 3v7pA-3rj8A:
undetectable		 3v7pA-3rj8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 11 VAL A 163
ALA A 175
GLY A 189
LEU A 183
GLY A 191
 None
 1.06A 3zosA-3rj8A:
1.1
3zosB-3rj8A:
1.0		 3zosA-3rj8A:
20.68
3zosB-3rj8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQE_B_DXCB1079_0
(PROTEIN PRGI, CELL
INVASION PROTEIN
SIPD)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 11 PRO A 208
THR A 212
LEU A 211
ARG A 243
SER A 149
 None
 1.15A 3zqeA-3rj8A:
0.0
3zqeB-3rj8A:
0.0		 3zqeA-3rj8A:
21.09
3zqeB-3rj8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 12 GLY A 195
ALA A 168
PHE A 457
ILE A 187
VAL A 165
 None
 1.23A 4azsA-3rj8A:
undetectable		 4azsA-3rj8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 12 GLY A 195
ALA A 168
PHE A 457
ILE A 187
VAL A 165
 None
 1.19A 4azwA-3rj8A:
undetectable		 4azwA-3rj8A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		3 / 3 GLY A 139
SER A 138
TRP A 200
 FAD  A 501 (-3.2A)
FAD  A 501 (-3.0A)
None
 0.96A 4e7cD-3rj8A:
undetectable		 4e7cD-3rj8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 10 TYR A 341
ASP A 251
PHE A 342
ILE A 230
PHE A 337
 None
 1.35A 4laxA-3rj8A:
undetectable		 4laxA-3rj8A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 9 THR A 414
LEU A 406
GLN A 387
PHE A 388
LEU A 326
 None
 1.30A 4ltwA-3rj8A:
undetectable		 4ltwA-3rj8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7T_A_SAMA503_0
(BTRN)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 11 HIS A 379
GLU A 445
TYR A 377
THR A 375
SER A 192
 None
None
None
None
FAD  A 501 (-4.0A)
 1.46A 4m7tA-3rj8A:
undetectable		 4m7tA-3rj8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		4 / 5 ARG A 125
TYR A  97
THR A 101
VAL A 161
 None
 1.41A 4mjqA-3rj8A:
undetectable		 4mjqA-3rj8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 10 CYH A  55
CYH A   6
LEU A   7
LEU A  84
ALA A  39
 None
 1.26A 4p65A-3rj8A:
undetectable
4p65B-3rj8A:
undetectable
4p65F-3rj8A:
undetectable
4p65H-3rj8A:
undetectable		 4p65A-3rj8A:
4.45
4p65B-3rj8A:
5.84
4p65F-3rj8A:
5.84
4p65H-3rj8A:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		4 / 4 THR A 131
LEU A 112
HIS A 140
GLY A 134
 FAD  A 501 (-3.7A)
None
FAD  A 501 (-3.8A)
None
 1.44A 5gwyA-3rj8A:
undetectable		 5gwyA-3rj8A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		4 / 6 CYH A  55
CYH A   6
LEU A   7
LEU A  84
 None
 1.21A 5hpuC-3rj8A:
undetectable
5hpuD-3rj8A:
undetectable		 5hpuC-3rj8A:
4.45
5hpuD-3rj8A:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 12 VAL A 165
VAL A 163
SER A  67
LEU A 450
ILE A 426
 None
None
FAD  A 501 (-3.4A)
None
None
 1.15A 5hv1A-3rj8A:
undetectable		 5hv1A-3rj8A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 11 ASP A 358
PHE A 247
VAL A 233
ILE A 230
ILE A 386
 None
 1.40A 5hwcA-3rj8A:
undetectable		 5hwcA-3rj8A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		3 / 3 GLY A  69
GLY A  68
GLN A  87
 FAD  A 501 (-3.3A)
FAD  A 501 (-3.2A)
None
 0.30A 5imsA-3rj8A:
undetectable		 5imsA-3rj8A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		3 / 3 ASP A 430
PHE A 403
ARG A  32
 None
 1.03A 5yw0A-3rj8A:
undetectable		 5yw0A-3rj8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 12 LEU A 450
GLY A 189
GLY A 191
GLY A 195
PRO A 471
 None
 1.04A 6ce2B-3rj8A:
undetectable		 6ce2B-3rj8A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		4 / 5 ARG A  32
LEU A  33
PHE A  77
PHE A 319
 None
 1.30A 6nmpP-3rj8A:
undetectable
6nmpW-3rj8A:
undetectable		 6nmpP-3rj8A:
17.99
6nmpW-3rj8A:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 3rj8 CARBOHYDRATE OXIDASE
(Microdochium
nivale) 		5 / 10 PHE A 148
LEU A 202
ASP A 158
LEU A 155
GLY A 154
 None
 1.35A 6r2eD-3rj8A:
undetectable		 6r2eD-3rj8A:
21.25