SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rj9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		5 / 12 ILE A 132
ILE A 179
LEU A  25
LEU A   3
ILE A  87
 None
 0.99A 1df7A-3rj9A:
undetectable		 1df7A-3rj9A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		5 / 12 LEU A 188
PHE A 192
SER A 152
ILE A 145
LEU A 206
 NAD  A 850 (-3.4A)
None
None
None
None
 1.26A 1dreA-3rj9A:
undetectable		 1dreA-3rj9A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		4 / 6 ILE A  94
ASN A 107
SER A 154
THR A 140
 None
 1.26A 1h7xA-3rj9A:
4.7		 1h7xA-3rj9A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		4 / 6 ILE A  94
ASN A 107
SER A 154
THR A 140
 None
 1.27A 1h7xB-3rj9A:
4.9		 1h7xB-3rj9A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		4 / 6 ILE A  94
ASN A 107
SER A 154
THR A 140
 None
 1.27A 1h7xC-3rj9A:
4.2		 1h7xC-3rj9A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		4 / 6 ILE A  94
ASN A 107
SER A 154
THR A 140
 None
 1.27A 1h7xD-3rj9A:
5.3		 1h7xD-3rj9A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		3 / 3 ALA A 157
VAL A 159
TRP A 246
 None
 0.88A 1micA-3rj9A:
undetectable
1micB-3rj9A:
undetectable		 1micA-3rj9A:
5.49
1micB-3rj9A:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		5 / 12 TYR A 151
ILE A  17
ALA A 156
SER A 154
GLY A 182
 NAD  A 850 (-4.8A)
NAD  A 850 (-4.0A)
None
None
NAD  A 850 (-4.9A)
 1.13A 1nbiA-3rj9A:
6.6		 1nbiA-3rj9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		5 / 12 TYR A 151
ILE A  17
ALA A 156
SER A 154
GLY A 182
 NAD  A 850 (-4.8A)
NAD  A 850 (-4.0A)
None
None
NAD  A 850 (-4.9A)
 1.13A 1nbiB-3rj9A:
6.8		 1nbiB-3rj9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		5 / 12 LEU A 188
PHE A 192
SER A 152
ILE A 145
LEU A 206
 NAD  A 850 (-3.4A)
None
None
None
None
 1.27A 1rh3A-3rj9A:
undetectable		 1rh3A-3rj9A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		5 / 12 ILE A 225
ALA A 224
ASN A 135
PHE A 221
VAL A   8
 None
 1.13A 1xdkA-3rj9A:
undetectable		 1xdkA-3rj9A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		5 / 12 ALA A 134
ILE A 133
ILE A  89
VAL A   8
ILE A  78
 None
 1.09A 1xozA-3rj9A:
undetectable		 1xozA-3rj9A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		4 / 4 SER A  22
ASP A  37
ARG A  38
ASP A  63
 None
NAD  A 850 (-2.7A)
None
NAD  A 850 (-3.3A)
 1.45A 2bm9C-3rj9A:
5.5		 2bm9C-3rj9A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		4 / 7 VAL A  85
THR A  84
PHE A  79
LYS A  76
 None
 1.11A 2kotA-3rj9A:
undetectable		 2kotA-3rj9A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		4 / 8 VAL A  85
THR A  84
PHE A  79
LYS A  76
 None
 1.17A 2kotB-3rj9A:
undetectable		 2kotB-3rj9A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		5 / 11 ILE A  17
GLY A  18
PHE A  10
GLY A  91
PRO A 181
 NAD  A 850 (-4.0A)
None
None
NAD  A 850 (-4.7A)
NAD  A 850 (-3.9A)
 1.03A 2y7kA-3rj9A:
undetectable		 2y7kA-3rj9A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		5 / 12 ILE A  17
GLY A  18
PHE A  10
GLY A  91
PRO A 181
 NAD  A 850 (-4.0A)
None
None
NAD  A 850 (-4.7A)
NAD  A 850 (-3.9A)
 1.11A 2y7kC-3rj9A:
undetectable		 2y7kC-3rj9A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		5 / 12 ILE A  17
GLY A  18
PHE A  10
GLY A  91
PRO A 181
 NAD  A 850 (-4.0A)
None
None
NAD  A 850 (-4.7A)
NAD  A 850 (-3.9A)
 1.12A 2y7kD-3rj9A:
undetectable		 2y7kD-3rj9A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		5 / 10 ILE A  17
GLY A  18
PHE A  10
GLY A  91
PRO A 181
 NAD  A 850 (-4.0A)
None
None
NAD  A 850 (-4.7A)
NAD  A 850 (-3.9A)
 1.32A 2y7wB-3rj9A:
undetectable		 2y7wB-3rj9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		4 / 8 LEU A  45
ILE A  35
PHE A  10
GLY A  18
 None
 0.83A 3b9lA-3rj9A:
undetectable		 3b9lA-3rj9A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		5 / 12 GLY A 110
ILE A 136
GLY A  93
ILE A  94
VAL A 158
 None
NAD  A 850 (-3.9A)
NAD  A 850 (-3.6A)
None
None
 0.92A 3el4A-3rj9A:
undetectable		 3el4A-3rj9A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		4 / 8 GLY A  91
ASN A  90
PHE A 221
ILE A 179
 NAD  A 850 (-4.7A)
None
None
None
 0.84A 4j4vC-3rj9A:
undetectable		 4j4vC-3rj9A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		5 / 10 LEU A   3
LEU A  30
ARG A  28
ILE A 225
THR A  58
 None
 1.34A 4mk4A-3rj9A:
3.5		 4mk4A-3rj9A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3rj9 ALCOHOL
DEHYDROGENASE
(Scaptodrosophila
lebanonensis) 		5 / 11 TRP A 250
ASP A 251
SER A 252
GLY A 231
ALA A 134
 None
 1.31A 6hu9A-3rj9A:
undetectable
6hu9E-3rj9A:
undetectable
6hu9I-3rj9A:
undetectable		 6hu9A-3rj9A:
23.56
6hu9E-3rj9A:
21.49
6hu9I-3rj9A:
11.81