SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rjo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)		 3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 HIS A 943
HIS A 944
HIS A 945
 None
 0.64A 1rkyA-3rjoA:
undetectable		 1rkyA-3rjoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 5 PHE A 702
LEU A 664
PHE A 699
MET A 683
 None
 1.37A 1wrkB-3rjoA:
undetectable		 1wrkB-3rjoA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 SER A 648
PHE A 702
PHE A 699
MET A 683
 EDO  A   1 ( 4.3A)
None
None
None
 0.94A 1wrlC-3rjoA:
undetectable
1wrlD-3rjoA:
undetectable		 1wrlC-3rjoA:
11.63
1wrlD-3rjoA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 MET A 604
THR A 534
LEU A 532
ILE A 533
VAL A 602
 None
 1.29A 1wsvA-3rjoA:
undetectable		 1wsvA-3rjoA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 10 GLY A 893
THR A 879
VAL A 891
GLU A 890
SER A 897
 None
 1.27A 1z35A-3rjoA:
undetectable		 1z35A-3rjoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 GLU A 669
ASN A 634
PRO A 672
ALA A 637
 None
 1.49A 2ejgB-3rjoA:
undetectable		 2ejgB-3rjoA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 HIS A 943
HIS A 944
HIS A 945
 None
 0.69A 2w0qA-3rjoA:
undetectable		 2w0qA-3rjoA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 LEU A 591
LEU A 589
ILE A 535
TYR A 612
PHE A 569
 None
 1.16A 2weyA-3rjoA:
undetectable		 2weyA-3rjoA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 LEU A 710
LEU A 707
THR A 629
VAL A 673
 None
 0.85A 3dcjB-3rjoA:
undetectable		 3dcjB-3rjoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 HIS A 943
HIS A 944
HIS A 945
 None
 0.73A 3hiiA-3rjoA:
undetectable		 3hiiA-3rjoA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 HIS A 943
HIS A 944
HIS A 945
 None
 0.71A 3hiiB-3rjoA:
undetectable		 3hiiB-3rjoA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.87A 5b1aC-3rjoA:
undetectable
5b1aJ-3rjoA:
undetectable		 5b1aC-3rjoA:
20.24
5b1aJ-3rjoA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.87A 5b1aP-3rjoA:
1.6
5b1aW-3rjoA:
undetectable		 5b1aP-3rjoA:
20.24
5b1aW-3rjoA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.85A 5b3sC-3rjoA:
undetectable
5b3sJ-3rjoA:
undetectable		 5b3sC-3rjoA:
20.24
5b3sJ-3rjoA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.84A 5b3sP-3rjoA:
1.6		 5b3sP-3rjoA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 PHE A 864
ILE A 871
GLY A 877
LEU A 836
THR A 837
 None
 1.05A 5byjA-3rjoA:
undetectable		 5byjA-3rjoA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 GLY A 676
GLN A 675
LEU A 686
GLY A 920
PHE A 699
 None
 0.94A 5fsaB-3rjoA:
undetectable		 5fsaB-3rjoA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 THR A 534
MET A 544
HIS A 543
 None
 0.89A 5uunA-3rjoA:
1.7		 5uunA-3rjoA:
21.79