SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rjt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		3 / 3 GLN A  96
HIS A 106
PRO A 100
 None
 0.99A 1d8cA-3rjtA:
undetectable		 1d8cA-3rjtA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		5 / 12 HIS A 199
GLY A  35
ASN A  34
GLY A  19
VAL A  37
 CSO  A  18 ( 4.2A)
CSO  A  18 ( 3.8A)
None
CSO  A  18 ( 2.4A)
None
 1.26A 1ffyA-3rjtA:
undetectable		 1ffyA-3rjtA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		3 / 3 ALA A  42
HIS A  43
VAL A  46
 None
 0.50A 1lqtB-3rjtA:
undetectable		 1lqtB-3rjtA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		3 / 3 ALA A  42
HIS A  43
VAL A  46
 None
 0.52A 1lquB-3rjtA:
undetectable		 1lquB-3rjtA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		3 / 3 LYS A  19
ASP A  92
ASP A  17
 CSO  A  18 ( 3.2A)
None
CSO  A  18 ( 3.9A)
 1.00A 2br4D-3rjtA:
2.7		 2br4D-3rjtA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		5 / 12 GLY A  59
GLY A  25
ASP A  13
LEU A 119
VAL A  56
 None
None
ACT  A 301 (-3.8A)
None
None
 1.06A 2hmyB-3rjtA:
undetectable		 2hmyB-3rjtA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		4 / 7 ASP A 144
TYR A 137
PRO A 140
THR A 184
 EDO  A 303 (-2.8A)
EDO  A 303 (-4.5A)
None
None
 1.43A 2q6kA-3rjtA:
2.8		 2q6kA-3rjtA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		5 / 12 LEU A 138
ASP A  13
ASN A  91
PHE A 136
HIS A 199
 None
ACT  A 301 (-3.8A)
ACT  A 301 (-3.0A)
None
CSO  A  18 ( 4.2A)
 1.11A 2x2iA-3rjtA:
2.9		 2x2iA-3rjtA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		5 / 12 LEU A 138
ASP A  13
ASN A  91
PHE A 136
HIS A 199
 None
ACT  A 301 (-3.8A)
ACT  A 301 (-3.0A)
None
CSO  A  18 ( 4.2A)
 1.09A 2x2iB-3rjtA:
2.8		 2x2iB-3rjtA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		4 / 8 TYR A  36
VAL A  56
ILE A  88
GLY A  59
 None
 0.96A 3hjoA-3rjtA:
undetectable		 3hjoA-3rjtA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		4 / 8 SER A  61
ASN A  63
ARG A  71
GLY A  19
 ACT  A 301 ( 4.3A)
None
None
CSO  A  18 ( 2.4A)
 0.98A 4af0A-3rjtA:
undetectable		 4af0A-3rjtA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		4 / 8 TYR A 112
ASP A  13
VAL A  68
LEU A 116
 None
ACT  A 301 (-3.8A)
None
None
 1.08A 4f8hA-3rjtA:
undetectable
4f8hB-3rjtA:
undetectable		 4f8hA-3rjtA:
19.88
4f8hB-3rjtA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		4 / 8 TYR A 112
ASP A  13
VAL A  68
LEU A 116
 None
ACT  A 301 (-3.8A)
None
None
 1.09A 4f8hB-3rjtA:
undetectable
4f8hC-3rjtA:
undetectable		 4f8hB-3rjtA:
19.88
4f8hC-3rjtA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		4 / 8 TYR A 112
ASP A  13
VAL A  68
LEU A 116
 None
ACT  A 301 (-3.8A)
None
None
 1.08A 4f8hC-3rjtA:
undetectable
4f8hD-3rjtA:
undetectable		 4f8hC-3rjtA:
19.88
4f8hD-3rjtA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		4 / 8 TYR A 112
ASP A  13
VAL A  68
LEU A 116
 None
ACT  A 301 (-3.8A)
None
None
 1.09A 4f8hD-3rjtA:
undetectable
4f8hE-3rjtA:
undetectable		 4f8hD-3rjtA:
19.88
4f8hE-3rjtA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		4 / 8 VAL A  68
LEU A 116
TYR A 112
ASP A  13
 None
None
None
ACT  A 301 (-3.8A)
 1.09A 4f8hA-3rjtA:
undetectable
4f8hE-3rjtA:
undetectable		 4f8hA-3rjtA:
19.88
4f8hE-3rjtA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		4 / 6 ASP A  92
ALA A  66
THR A 115
TYR A 112
 None
 1.47A 4w5qA-3rjtA:
3.8		 4w5qA-3rjtA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		4 / 6 ASP A  92
ALA A  66
THR A 115
TYR A 112
 None
 1.49A 4w5rA-3rjtA:
3.8		 4w5rA-3rjtA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		4 / 6 ASP A  92
ALA A  66
THR A 115
TYR A 112
 None
 1.49A 4z4cA-3rjtA:
3.7		 4z4cA-3rjtA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		4 / 7 LEU A 138
PRO A 194
ILE A 202
LEU A 133
 None
 1.04A 5fxtA-3rjtA:
undetectable		 5fxtA-3rjtA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		4 / 4 LEU A 133
MET A 130
ILE A 154
LEU A 116
 None
 1.15A 5nfpA-3rjtA:
undetectable		 5nfpA-3rjtA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		3 / 3 GLU A 139
ARG A 191
TYR A 137
 None
EDO  A 303 (-3.3A)
EDO  A 303 (-4.5A)
 0.66A 5trqB-3rjtA:
undetectable		 5trqB-3rjtA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 3rjt LIPOLYTIC PROTEIN
G-D-S-L FAMILY
(Alicyclobacillus
acidocaldarius) 		4 / 6 GLU A  73
ARG A 126
VAL A  84
PRO A  81
 None
 1.49A 6fgdA-3rjtA:
2.9		 6fgdA-3rjtA:
19.29