SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rk6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLN A 218
GLU A 257
GLU A 252
ARG A 222
 None
 1.16A 1dtlA-3rk6A:
undetectable		 1dtlA-3rk6A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 117
GLU A 120
LEU A 121
LEU A  79
LEU A 150
 None
 0.95A 1errB-3rk6A:
undetectable		 1errB-3rk6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens) 		6 / 12 ARG A 222
LEU A 195
VAL A 192
LEU A 228
ALA A 178
PHE A 188
 None
 1.42A 1gseB-3rk6A:
3.1		 1gseB-3rk6A:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 243
LEU A 225
GLU A 223
GLY A 220
ALA A 214
 None
 1.08A 2bm9A-3rk6A:
undetectable		 2bm9A-3rk6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 243
LEU A 225
GLU A 223
GLY A 220
ALA A 214
 None
 1.04A 2bm9B-3rk6A:
undetectable		 2bm9B-3rk6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 243
LEU A 225
GLU A 223
GLY A 220
ALA A 214
 None
 1.10A 2bm9C-3rk6A:
undetectable		 2bm9C-3rk6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 243
LEU A 225
GLU A 223
GLY A 220
ALA A 214
 None
 1.12A 2bm9D-3rk6A:
undetectable		 2bm9D-3rk6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 THR A 114
ALA A 117
GLU A 120
LEU A 121
LEU A  79
 None
 1.15A 2qxsA-3rk6A:
undetectable		 2qxsA-3rk6A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ILE A 101
PHE A 104
ALA A 105
ARG A 166
LEU A 121
 None
 1.32A 2v0mA-3rk6A:
undetectable		 2v0mA-3rk6A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 152
ALA A 117
LEU A 118
VAL A 122
LEU A 142
 None
 1.10A 3ozuA-3rk6A:
undetectable		 3ozuA-3rk6A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 4 LEU A 244
GLY A 248
LEU A 251
GLU A 252
 None
 0.94A 3tgvB-3rk6A:
undetectable		 3tgvB-3rk6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 8 ILE A 132
GLN A 128
ILE A 125
LEU A  90
 None
 0.92A 4mj8A-3rk6A:
undetectable		 4mj8A-3rk6A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 246
LYS A 245
LEU A 251
LEU A 290
 None
 0.67A 5vkqA-3rk6A:
3.7
5vkqD-3rk6A:
4.4		 5vkqA-3rk6A:
8.83
5vkqD-3rk6A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 290
LEU A 246
LYS A 245
LEU A 251
 None
 0.67A 5vkqA-3rk6A:
3.7
5vkqB-3rk6A:
3.7		 5vkqA-3rk6A:
8.83
5vkqB-3rk6A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 290
LEU A 246
LYS A 245
LEU A 251
 None
 0.69A 5vkqB-3rk6A:
3.7
5vkqC-3rk6A:
3.7		 5vkqB-3rk6A:
8.83
5vkqC-3rk6A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 290
LEU A 246
LYS A 245
LEU A 251
 None
 0.66A 5vkqC-3rk6A:
3.7
5vkqD-3rk6A:
4.4		 5vkqC-3rk6A:
8.83
5vkqD-3rk6A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 6 VAL A  83
LEU A 108
LEU A 146
LEU A 118
 None
 1.04A 6f6sA-3rk6A:
undetectable
6f6sB-3rk6A:
undetectable		 6f6sA-3rk6A:
18.31
6f6sB-3rk6A:
14.10