SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rko'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DTL_A_BEPA205_1 (CARDIAC TROPONIN C)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K (Escherichia coli)	5 / 12	ALA J  12 ILE J  13 PHE J   5 LEU K  44 PHE J  43	None	1.17A	1dtlA-3rkoJ: undetectable	1dtlA-3rkoJ: 23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DTL_A_BEPA205_1 (CARDIAC TROPONIN C)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ILE N 269 PHE N 207 LEU N 316 LEU N 313 PHE N 251	None	1.19A	1dtlA-3rkoN: undetectable	1dtlA-3rkoN: 15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERR_A_CCSA381_0 (ESTROGEN RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	4 / 5	HIS N 224 GLU L 587 ALA N 288 SER N 301	None	1.30A	1errA-3rkoN: 1.9 1errB-3rkoN: undetectable	1errA-3rkoN: 21.21 1errB-3rkoN: 21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FM6_A_9CRA501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ILE N 250 ALA N 249 LEU N 119 ALA N 120 LEU N 306	None	0.87A	1fm6A-3rkoN: undetectable	1fm6A-3rkoN: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FM9_A_9CRA201_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ILE N 250 ALA N 249 LEU N 119 ALA N 120 LEU N 306	None	0.91A	1fm9A-3rkoN: undetectable	1fm9A-3rkoN: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1G50_B_ESTB1600_1 (ESTROGEN RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	LEU K  68 LEU N 134 ILE K  75 GLY J 151 LEU J 148	None	1.14A	1g50B-3rkoK: undetectable	1g50B-3rkoK: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1G50_C_ESTC2600_1 (ESTROGEN RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 11	LEU K  68 LEU N 134 ILE K  75 GLY J 151 LEU J 148	None	1.15A	1g50C-3rkoK: undetectable	1g50C-3rkoK: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTN_E_TRPE81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 6	THR M  94 SER M  43 GLY M 125 ILE M   7	None	0.80A	1gtnD-3rkoM: undetectable 1gtnE-3rkoM: undetectable	1gtnD-3rkoM: 9.84 1gtnE-3rkoM: 9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1H7X_A_URFA1033_1 (DIHYDROPYRIMIDINE DEHYDROGENASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 6	ASN N 121 ILE N   9 SER N  51 THR N  77	None	1.18A	1h7xA-3rkoN: undetectable	1h7xA-3rkoN: 18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1H7X_B_URFB1033_1 (DIHYDROPYRIMIDINE DEHYDROGENASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 6	ASN N 121 ILE N   9 SER N  51 THR N  77	None	1.18A	1h7xB-3rkoN: undetectable	1h7xB-3rkoN: 18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1H7X_C_URFC1033_1 (DIHYDROPYRIMIDINE DEHYDROGENASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 6	ASN N 121 ILE N   9 SER N  51 THR N  77	None	1.18A	1h7xC-3rkoN: undetectable	1h7xC-3rkoN: 18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1H7X_D_URFD1033_1 (DIHYDROPYRIMIDINE DEHYDROGENASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 6	ASN N 121 ILE N   9 SER N  51 THR N  77	None	1.18A	1h7xD-3rkoN: undetectable	1h7xD-3rkoN: 18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HK3_A_T44A3003_1 (SERUM ALBUMIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	3 / 4	LYS M 265 ALA M 268 MET M 345	None	1.02A	1hk3A-3rkoM: 3.0	1hk3A-3rkoM: 19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JLF_A_NVPA999_1 (HIV-1 RT A-CHAIN HIV-1 RT B-CHAIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 8	VAL L  35 TYR L 102 TRP L 105 TYR L 113	None	1.05A	1jlfA-3rkoL: undetectable 1jlfB-3rkoL: undetectable	1jlfA-3rkoL: 20.91 1jlfB-3rkoL: 19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JU6_A_LYAA317_1 (THYMIDYLATE SYNTHASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 11	PHE M 274 ILE M 189 GLY M 226 PHE M 227 ALA M 180	None None LFA  N 486 ( 4.1A) None None	1.39A	1ju6A-3rkoM: undetectable	1ju6A-3rkoM: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K74_A_9CRA463_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ILE N 250 ALA N 249 LEU N 119 ALA N 120 LEU N 306	None	0.88A	1k74A-3rkoN: undetectable	1k74A-3rkoN: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KT3_A_RTLA184_0 (PLASMA RETINOL-BINDING PROTEIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli; Escherichia coli)	4 / 7	LEU N 204 LEU N 202 TYR J 109 LEU L 606	None	1.08A	1kt3A-3rkoN: undetectable	1kt3A-3rkoN: 16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LQT_A_ACTA1871_0 (FPRA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 7	PHE N 105 PRO N 235 ALA N  91 SER N 345	None	1.22A	1lqtA-3rkoN: undetectable	1lqtA-3rkoN: 24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LQU_A_ACTA1428_0 (FPRA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 7	PHE N 105 PRO N 235 ALA N  91 SER N 345	None	1.22A	1lquA-3rkoN: undetectable	1lquA-3rkoN: 24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MT1_G_AG2G7003_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 6	LEU L 188 LEU L 181 GLY L 225 ILE L 266	None	0.90A	1mt1G-3rkoL: undetectable 1mt1J-3rkoL: undetectable	1mt1G-3rkoL: 6.36 1mt1J-3rkoL: 10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MT1_K_AG2K7002_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 7	ILE L 266 LEU L 188 LEU L 181 GLY L 225	None	0.91A	1mt1H-3rkoL: undetectable 1mt1K-3rkoL: undetectable	1mt1H-3rkoL: 10.42 1mt1K-3rkoL: 6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_D_THAD4_2 (LIVER CARBOXYLESTERASE I)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	3 / 3	PHE N 169 LEU K  19 MET K  31	None	0.88A	1mx1D-3rkoN: undetectable	1mx1D-3rkoN: 24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N5X_A_TEIA3006_1 (XANTHINE DEHYDROGENASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K (Escherichia coli)	5 / 12	LEU J  32 ASN K  40 GLU K  36 ALA K  69 ALA K  70	None	1.11A	1n5xA-3rkoJ: undetectable	1n5xA-3rkoJ: 9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N5X_A_TEIA3006_1 (XANTHINE DEHYDROGENASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	LEU J 147 GLU K  72 LEU N 137 PHE N 140 ALA N 164	None	1.14A	1n5xA-3rkoJ: undetectable	1n5xA-3rkoJ: 9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N5X_A_TEIA3006_1 (XANTHINE DEHYDROGENASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	LEU J 147 GLU K  72 LEU N 137 SER N 136 PHE N 140	None	1.19A	1n5xA-3rkoJ: undetectable	1n5xA-3rkoJ: 9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N5X_B_TEIB4006_1 (XANTHINE DEHYDROGENASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K (Escherichia coli)	5 / 12	LEU J  32 ASN K  40 GLU K  36 ALA K  69 ALA K  70	None	1.11A	1n5xB-3rkoJ: undetectable	1n5xB-3rkoJ: 9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N5X_B_TEIB4006_1 (XANTHINE DEHYDROGENASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	LEU J 147 GLU K  72 LEU N 137 PHE N 140 ALA N 164	None	1.14A	1n5xB-3rkoJ: undetectable	1n5xB-3rkoJ: 9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N5X_B_TEIB4006_1 (XANTHINE DEHYDROGENASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	LEU J 147 GLU K  72 LEU N 137 SER N 136 PHE N 140	None	1.19A	1n5xB-3rkoJ: undetectable	1n5xB-3rkoJ: 9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBI_C_SAMC2293_0 (GLYCINE N-METHYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 12	GLY M 428 THR M 426 SER M 433 GLY M 324 HIS M 322	None	1.29A	1nbiC-3rkoM: undetectable	1nbiC-3rkoM: 20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBI_D_SAMD3293_0 (GLYCINE N-METHYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 12	GLY M 428 THR M 426 SER M 433 GLY M 324 HIS M 322	None	1.29A	1nbiD-3rkoM: undetectable	1nbiD-3rkoM: 20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NV8_A_SAMA300_0 (HEMK PROTEIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 12	GLY L 228 GLY L 225 THR L 174 VAL L 176 PRO L 234	None	1.11A	1nv8A-3rkoL: undetectable	1nv8A-3rkoL: 20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NW5_A_SAMA401_0 (MODIFICATION METHYLASE RSRI)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli; Escherichia coli)	5 / 12	TRP L  67 PHE M 404 SER M 433 VAL M 430 ALA M 394	None	1.20A	1nw5A-3rkoL: undetectable	1nw5A-3rkoL: 20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NX9_A_AICA5001_1 (ALPHA-AMINO ACID ESTER HYDROLASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 8	TYR L 140 GLU M 407 SER M 321 TYR M 435	None	1.30A	1nx9A-3rkoL: undetectable	1nx9A-3rkoL: 21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NX9_B_AICB5002_1 (ALPHA-AMINO ACID ESTER HYDROLASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 8	TYR L 140 GLU M 407 SER M 321 TYR M 435	None	1.29A	1nx9B-3rkoL: undetectable	1nx9B-3rkoL: 21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NX9_C_AICC5003_1 (ALPHA-AMINO ACID ESTER HYDROLASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 8	TYR L 140 GLU M 407 SER M 321 TYR M 435	None	1.31A	1nx9C-3rkoL: undetectable	1nx9C-3rkoL: 21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NX9_D_AICD5004_1 (ALPHA-AMINO ACID ESTER HYDROLASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 8	TYR L 140 GLU M 407 SER M 321 TYR M 435	None	1.31A	1nx9D-3rkoL: undetectable	1nx9D-3rkoL: 21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_F_FUAF704_1 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 11	SER N  84 PHE N 241 SER N  41 VAL J 153 VAL N  21	None	1.39A	1q23F-3rkoN: undetectable	1q23F-3rkoN: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_I_FUAI707_2 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 11	SER N  84 PHE N 241 SER N  41 VAL J 153 VAL N  21	None	1.37A	1q23I-3rkoN: undetectable	1q23I-3rkoN: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QAB_F_RTLF2_0 (PROTEIN (RETINOL BINDING PROTEIN))	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 12	PHE M 116 LEU M  33 GLY M 360 LEU M 103 HIS M 159	None	1.25A	1qabF-3rkoM: undetectable	1qabF-3rkoM: 16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QZZ_A_SAMA635_0 (ACLACINOMYCIN-10-HYD ROXYLASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 12	GLY M 129 GLY M 126 GLY M 125 LEU M   6 PRO M  10	None	0.97A	1qzzA-3rkoM: undetectable	1qzzA-3rkoM: 21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S9P_C_DESC500_1 (ESTROGEN-RELATED RECEPTOR GAMMA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	LEU N  79 LEU N  82 LEU N  85 ALA N  86 ILE N 248	LFA  N 488 ( 4.8A) None None None None	0.99A	1s9pC-3rkoN: undetectable	1s9pC-3rkoN: 19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_B_PODB700_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT A NADH-QUINONE OXIDOREDUCTASE SUBUNIT J (Escherichia coli)	5 / 12	LEU A  62 ALA A  66 LEU A  70 MET A  73 ALA J 155	None	1.06A	1sa1A-3rkoA: undetectable 1sa1B-3rkoA: undetectable	1sa1A-3rkoA: 15.08 1sa1B-3rkoA: 14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_D_PODD701_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT A NADH-QUINONE OXIDOREDUCTASE SUBUNIT J (Escherichia coli)	5 / 12	LEU A  62 ALA A  66 LEU A  70 MET A  73 ALA J 155	None	1.05A	1sa1C-3rkoA: undetectable 1sa1D-3rkoA: undetectable	1sa1C-3rkoA: 15.08 1sa1D-3rkoA: 14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TKQ_B_DVAB8_0 (GRAMICIDIN A)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 5	VAL M 130 GLY M 129 VAL M 127 TRP M 122	None	1.31A	1tkqB-3rkoM: undetectable	1tkqB-3rkoM: 2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TW4_A_CHDA130_0 (FATTY ACID-BINDING PROTEIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 12	LEU L 239 ALA L 242 ILE L 154 MET L 258 ILE L  99	None	1.01A	1tw4A-3rkoL: undetectable	1tw4A-3rkoL: 13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UKB_A_BEZA1301_0 (2-HYDROXY-6-OXO-7-ME THYLOCTA-2,4-DIENOAT E HYDROLASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 6	LEU L 293 PHE L 296 ALA L 297 TRP L 535	None	1.03A	1ukbA-3rkoL: undetectable	1ukbA-3rkoL: 20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UTD_B_TRPB81_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 8	GLY M 125 ILE M   7 THR M  94 SER M  43	None	0.80A	1utdB-3rkoM: undetectable 1utdC-3rkoM: undetectable	1utdB-3rkoM: 9.84 1utdC-3rkoM: 9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UTD_J_TRPJ81_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 8	GLY M 125 ILE M   7 THR M  94 SER M  43	None	0.80A	1utdJ-3rkoM: undetectable 1utdK-3rkoM: undetectable	1utdJ-3rkoM: 9.84 1utdK-3rkoM: 9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA472_1 (CYTOCHROME P450 51)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 6	MET N 174 VAL N 254 LEU N 257 PHE N 186	None	1.14A	1x8vA-3rkoN: undetectable	1x8vA-3rkoN: 22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XDK_A_9CRA500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ILE N 250 ALA N 249 LEU N 119 ALA N 120 LEU N 306	None	0.91A	1xdkA-3rkoN: undetectable	1xdkA-3rkoN: 19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XDK_E_9CRE1500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ILE N 250 ALA N 249 LEU N 119 ALA N 120 LEU N 306	None	0.91A	1xdkE-3rkoN: undetectable	1xdkE-3rkoN: 19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XDK_F_9CRF1600_1 (RETINOIC ACID RECEPTOR, BETA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ALA N 120 LEU N 128 ILE N 132 ILE N 135 LEU N 214	None	1.02A	1xdkF-3rkoN: undetectable	1xdkF-3rkoN: 20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XDS_A_SAMA5635_0 (PROTEIN RDMB)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 12	GLY M 129 GLY M 126 GLY M 125 LEU M   6 PRO M  10	None	0.99A	1xdsA-3rkoM: undetectable	1xdsA-3rkoM: 21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XDS_B_SAMB9635_0 (PROTEIN RDMB)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 12	GLY M 129 GLY M 126 GLY M 125 LEU M   6 PRO M  10	None	0.99A	1xdsB-3rkoM: undetectable	1xdsB-3rkoM: 21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XIU_A_9CRA201_1 (RXR-LIKE PROTEIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ILE N 250 ALA N 249 LEU N 119 ALA N 120 LEU N 306	None	0.85A	1xiuA-3rkoN: undetectable	1xiuA-3rkoN: 20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLS_A_9CRA801_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ILE N 250 ALA N 249 LEU N 119 ALA N 120 LEU N 306	None	0.91A	1xlsA-3rkoN: undetectable	1xlsA-3rkoN: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLS_B_9CRB802_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ILE N 250 ALA N 249 LEU N 119 ALA N 120 LEU N 306	None	0.91A	1xlsB-3rkoN: undetectable	1xlsB-3rkoN: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLS_C_9CRC803_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ILE N 250 ALA N 249 LEU N 119 ALA N 120 LEU N 306	None	0.90A	1xlsC-3rkoN: undetectable	1xlsC-3rkoN: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLS_D_9CRD804_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ILE N 250 ALA N 249 LEU N 119 ALA N 120 LEU N 306	None	0.90A	1xlsD-3rkoN: undetectable	1xlsD-3rkoN: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XMU_B_ROFB102_0 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 12	MET L 432 TYR L 102 ILE L 353 MET L 243 SER L 250	None	1.23A	1xmuB-3rkoL: undetectable	1xmuB-3rkoL: 20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOQ_A_ROFA502_0 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 12	MET L 432 TYR L 102 ILE L 353 MET L 243 SER L 250	None	1.36A	1xoqA-3rkoL: undetectable	1xoqA-3rkoL: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XWF_A_ADNA433_2 (ADENOSYLHOMOCYSTEINA SE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	3 / 3	THR M 401 GLU M 407 HIS M 348	None	0.90A	1xwfA-3rkoM: undetectable	1xwfA-3rkoM: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA4_C_CTXC1383_1 (CES1 PROTEIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 5	TRP N  94 PRO N  93 LEU N 346 GLY N 342	None	1.44A	1ya4C-3rkoN: 0.9	1ya4C-3rkoN: 24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YAJ_D_BEZD2385_0 (CES1 PROTEIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli; Escherichia coli)	4 / 5	LEU K  68 LEU N 130 LEU N 128 LEU J 147	None	0.89A	1yajD-3rkoK: undetectable	1yajD-3rkoK: 13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YAJ_F_BEZF5023_0 (CES1 PROTEIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 6	LEU L  18 GLY L  34 SER L  37 ILE L 124	None	0.96A	1yajF-3rkoL: undetectable	1yajF-3rkoL: 22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A58_A_RBFA300_1 (6,7-DIMETHYL-8-RIBIT YLLUMAZINE SYNTHASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 11	GLY L 350 SER L 349 LEU L 308 ILE L 372 ALA L 355	None	1.42A	2a58A-3rkoL: undetectable 2a58E-3rkoL: undetectable	2a58A-3rkoL: 13.05 2a58E-3rkoL: 13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A58_D_RBFD303_1 (6,7-DIMETHYL-8-RIBIT YLLUMAZINE SYNTHASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 11	ILE L 372 ALA L 355 GLY L 350 SER L 349 LEU L 308	None	1.42A	2a58C-3rkoL: undetectable 2a58D-3rkoL: undetectable	2a58C-3rkoL: 13.05 2a58D-3rkoL: 13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AA6_B_STRB402_1 (MINERALOCORTICOID RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	LEU N 118 ALA N 122 MET N 174 MET K  61 LEU N 184	None	1.36A	2aa6B-3rkoN: undetectable	2aa6B-3rkoN: 19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AVS_B_MK1B902_1 (POL POLYPROTEIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 12	LEU M   6 VAL M 127 GLY M  98 VAL M  99 ILE M 128	None	0.88A	2avsA-3rkoM: undetectable	2avsA-3rkoM: 14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CBR_A_A80A201_1 (PROTEIN (CRABP-I))	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 12	LEU L 132 VAL L 128 VAL L  92 GLY L  83 LEU L 323	None	1.06A	2cbrA-3rkoL: undetectable	2cbrA-3rkoL: 10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CIZ_A_ACTA1320_0 (CHLOROPEROXIDASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	4 / 6	PHE M  75 ILE N 475 VAL N 328 GLU N 324	None	0.92A	2cizA-3rkoM: undetectable	2cizA-3rkoM: 20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F8G_B_017B401_1 (POL POLYPROTEIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 12	LEU M   6 VAL M 127 GLY M  98 VAL M  99 ILE M 128	None	1.00A	2f8gA-3rkoM: undetectable	2f8gA-3rkoM: 14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FL5_B_RBFB202_1 (IMMUNOGLOBULIN IGG1 LAMBDA LIGHT CHAIN IMMUNOGLOBULIN IGG1 HEAVY CHAIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 11	TYR N 159 GLU K  72 PHE N 140 VAL J 158 GLU K  36	None	1.47A	2fl5A-3rkoN: undetectable 2fl5B-3rkoN: undetectable 2fl5F-3rkoN: undetectable	2fl5A-3rkoN: 19.34 2fl5B-3rkoN: 19.20 2fl5F-3rkoN: 19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FL5_F_RBFF204_1 (IMMUNOGLOBULIN IGG1 LAMBDA LIGHT CHAIN IMMUNOGLOBULIN IGG1 HEAVY CHAIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 8	TYR N 159 GLU K  72 PHE N 140 VAL J 158	None	1.01A	2fl5E-3rkoN: undetectable 2fl5F-3rkoN: undetectable	2fl5E-3rkoN: 19.34 2fl5F-3rkoN: 19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FL5_H_RBFH201_1 (IMMUNOGLOBULIN IGG1 HEAVY CHAIN IMMUNOGLOBULIN IGG1 LAMBDA LIGHT CHAIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 9	GLU K  36 GLU K  72 PHE N 140 VAL J 158 TYR N 159	None	1.45A	2fl5D-3rkoK: undetectable 2fl5H-3rkoK: undetectable 2fl5L-3rkoK: undetectable	2fl5D-3rkoK: 20.45 2fl5H-3rkoK: 20.45 2fl5L-3rkoK: 16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FXD_A_DR7A102_1 (POL PROTEIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 11	ILE N 314 LEU N 273 GLY N 208 GLY L 601 VAL N 272	None	0.90A	2fxdA-3rkoN: undetectable	2fxdA-3rkoN: 13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J9C_C_ACTC1120_0 (HYPOTHETICAL NITROGEN REGULATORY PII-LIKE PROTEIN MJ0059)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K (Escherichia coli; Escherichia coli)	3 / 3	LYS K   1 TYR J   6 PRO K   3	None	1.35A	2j9cC-3rkoK: undetectable	2j9cC-3rkoK: 13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2M2P_B_DHIB24_0 (INSULIN B CHAIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	3 / 3	TYR N 159 GLY N 144 PHE N 140	None	0.68A	2m2pB-3rkoN: undetectable	2m2pB-3rkoN: 6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2M56_A_CAMA502_0 (CAMPHOR 5-MONOOXYGENASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 5	PHE L 549 TYR L 545 LEU L 235 VAL L 176	LFA  L 614 ( 4.2A) LFA  L 614 ( 4.4A) None None	1.22A	2m56A-3rkoL: undetectable	2m56A-3rkoL: 22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NMY_A_ROCA401_2 (PROTEASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT A NADH-QUINONE OXIDOREDUCTASE SUBUNIT J (Escherichia coli)	5 / 12	LEU A  83 GLY J  52 ALA J  53 ILE J 124 ALA A  87	None	0.97A	2nmyB-3rkoA: undetectable	2nmyB-3rkoA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OPX_A_DXCA1002_0 (ALDEHYDE DEHYDROGENASE A)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli; Escherichia coli)	3 / 3	GLY L 589 ARG K  99 TYR L 594	None	0.87A	2opxA-3rkoL: undetectable	2opxA-3rkoL: 23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OTH_A_NIMA300_1 (PHOSPHOLIPASE A2 VRV-PL-VIIIA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT A NADH-QUINONE OXIDOREDUCTASE SUBUNIT J (Escherichia coli)	4 / 5	LEU A  20 ALA J  53 ILE J  56 SER J  40	None	0.85A	2othA-3rkoA: 2.2	2othA-3rkoA: 18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OZ7_A_CA4A1_1 (ANDROGEN RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT A NADH-QUINONE OXIDOREDUCTASE SUBUNIT J (Escherichia coli)	5 / 12	LEU A 117 LEU A 114 GLY A 113 VAL A  76 ALA J 155	None	1.17A	2oz7A-3rkoA: undetectable	2oz7A-3rkoA: 18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OZ7_A_CA4A1_1 (ANDROGEN RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K (Escherichia coli)	5 / 12	LEU K  19 LEU K  22 GLY K  21 ALA J 101 LEU J 104	None	1.07A	2oz7A-3rkoK: undetectable	2oz7A-3rkoK: 20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PNJ_B_CHDB501_0 (FERROCHELATASE, MITOCHONDRIAL)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT A NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli; Escherichia coli; Escherichia coli)	5 / 12	LEU N 134 LEU J 147 SER K  67 VAL A  80 VAL A 109	None	1.28A	2pnjB-3rkoN: undetectable	2pnjB-3rkoN: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PO7_B_CHDB503_0 (FERROCHELATASE, MITOCHONDRIAL)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	3 / 3	LEU N 139 PRO N 138 LEU N 142	None	0.45A	2po7B-3rkoN: undetectable	2po7B-3rkoN: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD4_B_CHDB926_0 (FERROCHELATASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 10	LEU L 153 ILE L 253 PRO L  11 VAL L  92 GLY L  96	None	1.33A	2qd4B-3rkoL: undetectable	2qd4B-3rkoL: 19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RLC_A_CHDA332_0 (CHOLOYLGLYCINE HYDROLASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli; Escherichia coli)	5 / 12	ILE M 176 ALA L 573 ILE N 282 ILE N 281 LEU N 289	None	0.90A	2rlcA-3rkoM: undetectable	2rlcA-3rkoM: 21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_A_KLNA1500_1 (CYTOCHROME P450 3A4)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 11	PHE J  67 SER N 136 LEU N 171 ALA N 166 LEU K  35	None	1.37A	2v0mA-3rkoJ: undetectable	2v0mA-3rkoJ: 16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_C_KLNC1499_1 (CYTOCHROME P450 3A4)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K (Escherichia coli)	4 / 7	LEU J  46 PHE J   5 ILE J  39 GLY K  50	None	0.90A	2v0mC-3rkoJ: undetectable	2v0mC-3rkoJ: 16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V2G_A_BEZA1222_0 (PEROXIREDOXIN 6)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 7	THR L 247 PRO L 248 VAL L 249 SER L 250	None	0.87A	2v2gA-3rkoL: undetectable 2v2gB-3rkoL: undetectable	2v2gA-3rkoL: 15.99 2v2gB-3rkoL: 15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V2G_B_BEZB1220_0 (PEROXIREDOXIN 6)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 7	THR L 247 PRO L 248 VAL L 249 SER L 250	None	0.88A	2v2gA-3rkoL: undetectable 2v2gB-3rkoL: undetectable	2v2gA-3rkoL: 15.99 2v2gB-3rkoL: 15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V2G_C_BEZC1222_0 (PEROXIREDOXIN 6)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 7	THR L 247 PRO L 248 VAL L 249 SER L 250	None	0.87A	2v2gC-3rkoL: undetectable 2v2gD-3rkoL: undetectable	2v2gC-3rkoL: 15.99 2v2gD-3rkoL: 15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V2G_D_BEZD1221_0 (PEROXIREDOXIN 6)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 7	THR L 247 PRO L 248 VAL L 249 SER L 250	None	0.90A	2v2gC-3rkoL: undetectable 2v2gD-3rkoL: undetectable	2v2gC-3rkoL: 15.99 2v2gD-3rkoL: 15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V32_A_BEZA1222_0 (PEROXIREDOXIN 6)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 8	THR L 247 PRO L 248 VAL L 249 SER L 250	None	0.86A	2v32A-3rkoL: undetectable 2v32B-3rkoL: undetectable	2v32A-3rkoL: 15.99 2v32B-3rkoL: 15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V32_B_BEZB1220_0 (PEROXIREDOXIN 6)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 8	THR L 247 PRO L 248 VAL L 249 SER L 250	None	0.87A	2v32A-3rkoL: undetectable 2v32B-3rkoL: undetectable	2v32A-3rkoL: 15.99 2v32B-3rkoL: 15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V32_C_BEZC1222_0 (PEROXIREDOXIN 6)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 8	THR L 247 PRO L 248 VAL L 249 SER L 250	None	0.86A	2v32C-3rkoL: undetectable 2v32D-3rkoL: undetectable	2v32C-3rkoL: 15.99 2v32D-3rkoL: 15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V32_D_BEZD1221_0 (PEROXIREDOXIN 6)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 8	THR L 247 PRO L 248 VAL L 249 SER L 250	None	0.89A	2v32C-3rkoL: undetectable 2v32D-3rkoL: undetectable	2v32C-3rkoL: 15.99 2v32D-3rkoL: 15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V3K_A_SAMA1254_0 (ESSENTIAL FOR MITOTIC GROWTH 1)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	6 / 10	LEU N 214 PHE N 216 VAL N 254 GLY N 213 LEU N 170 SER N 167	None	1.43A	2v3kA-3rkoN: undetectable	2v3kA-3rkoN: 20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_C_BEZC1218_0 (PEROXIREDOXIN 6.)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 8	THR L 247 PRO L 248 VAL L 249 SER L 250	None	0.91A	2v41C-3rkoL: undetectable 2v41D-3rkoL: undetectable	2v41C-3rkoL: 15.99 2v41D-3rkoL: 15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_D_BEZD1222_0 (PEROXIREDOXIN 6.)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 8	THR L 247 PRO L 248 VAL L 249 SER L 250	None	0.91A	2v41C-3rkoL: undetectable 2v41D-3rkoL: undetectable	2v41C-3rkoL: 15.99 2v41D-3rkoL: 15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_E_BEZE1222_0 (PEROXIREDOXIN 6.)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 7	THR L 247 PRO L 248 VAL L 249 SER L 250	None	0.87A	2v41E-3rkoL: undetectable 2v41F-3rkoL: undetectable	2v41E-3rkoL: 15.99 2v41F-3rkoL: 15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_H_BEZH1222_0 (PEROXIREDOXIN 6.)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 8	THR L 247 PRO L 248 VAL L 249 SER L 250	None	0.94A	2v41G-3rkoL: undetectable 2v41H-3rkoL: undetectable	2v41G-3rkoL: 15.99 2v41H-3rkoL: 15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V57_A_PRLA1188_0 (TETR FAMILY TRANSCRIPTIONAL REPRESSOR LFRR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 8	HIS N 305 SER N 304 ILE N 281 TYR N 425	None	1.07A	2v57A-3rkoN: 0.6	2v57A-3rkoN: 17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V57_C_PRLC1187_0 (TETR FAMILY TRANSCRIPTIONAL REPRESSOR LFRR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 8	HIS N 305 SER N 304 ILE N 281 TYR N 425	None	1.06A	2v57C-3rkoN: 0.5	2v57C-3rkoN: 17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V95_A_HCYA1375_1 (CORTICOSTEROID-BINDI NG GLOBULIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ALA N  48 PRO N  13 VAL N  17 THR N  87 PHE N 241	None	1.29A	2v95A-3rkoN: undetectable	2v95A-3rkoN: 21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W3B_B_FOLB401_1 (DIHYDROFOLATE REDUCTASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	3 / 3	GLU M 108 GLN M 361 ARG M 365	None	0.66A	2w3bB-3rkoM: undetectable	2w3bB-3rkoM: 15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WD9_C_IBPC1570_1 (ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K (Escherichia coli)	5 / 10	THR J 132 ILE J 124 GLY K  54 GLN K  55 THR K  56	None	1.14A	2wd9C-3rkoJ: undetectable	2wd9C-3rkoJ: 14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2N_C_X2NC1479_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	PHE N 241 VAL N  21 ALA N 245 ALA N 249 MET J 146	None	1.09A	2x2nC-3rkoN: undetectable	2x2nC-3rkoN: 23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XRH_A_NIOA200_1 (PROTEIN HP0721)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 7	GLY L 317 ILE L 402 GLN L 315 LEU L 291	None	1.01A	2xrhA-3rkoL: undetectable	2xrhA-3rkoL: 10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y6R_B_CTCB1385_0 (TETX2 PROTEIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 8	ARG M 273 PHE M 131 GLY M 129 GLY M  85	None	0.95A	2y6rB-3rkoM: undetectable	2y6rB-3rkoM: 22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZIF_B_SAMB298_0 (PUTATIVE MODIFICATION METHYLASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	5 / 12	SER N 168 ALA K  41 PHE K  15 LEU K  64 TYR K  62	None	1.19A	2zifB-3rkoN: undetectable	2zifB-3rkoN: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A2Q_A_ACAA601_1 (6-AMINOHEXANOATE-CYC LIC-DIMER HYDROLASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 7	GLY M 333 ALA M 284 ALA M 287 VAL M 504	None	0.81A	3a2qA-3rkoM: undetectable	3a2qA-3rkoM: 21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ADX_A_IMNA2_2 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 7	ILE M  83 ILE M 346 LEU M   3 LEU M  40	None	0.96A	3adxA-3rkoM: undetectable	3adxA-3rkoM: 19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BXO_B_SAMB238_0 (N,N-DIMETHYLTRANSFER ASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 12	ALA L 385 GLY L 395 LEU L 389 PHE L 340 SER L 464	None None None LFA  L 616 (-4.4A) None	1.33A	3bxoB-3rkoL: undetectable	3bxoB-3rkoL: 16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D90_B_NOGB2001_1 (PROGESTERONE RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT K (Escherichia coli)	5 / 12	LEU K  90 LEU K  28 ASN K  27 LEU K  35 LEU K  77	None	1.30A	3d90B-3rkoK: undetectable	3d90B-3rkoK: 20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DH0_A_SAMA220_1 (SAM DEPENDENT METHYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 8	TYR M 338 ASP M  84 GLN M  62 GLU M 208	None	1.43A	3dh0A-3rkoM: undetectable	3dh0A-3rkoM: 17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DOU_A_SAMA1_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	5 / 12	GLY N 215 PRO N 222 GLY L 601 LEU N 306 ILE N 250	None	0.87A	3douA-3rkoN: undetectable	3douA-3rkoN: 16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DZY_A_9CRA463_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ILE N 250 ALA N 249 LEU N 119 ALA N 120 LEU N 306	None	1.00A	3dzyA-3rkoN: undetectable	3dzyA-3rkoN: 20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EL9_A_DR7A100_2 (PROTEASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 10	GLY M 261 ALA M 260 ILE M 123 PRO M 252 THR M 253	None	1.07A	3el9B-3rkoM: undetectable	3el9B-3rkoM: 14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3F33_A_PFLA2001_1 (FERRITIN LIGHT CHAIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 6	LEU J 143 SER J 145 LEU J 149 LEU N 134	None	0.77A	3f33A-3rkoJ: undetectable	3f33A-3rkoJ: 25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FW1_A_STIA233_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 10	PHE L 340 GLY L  96 GLY L  94 THR L  93 ILE L 124	LFA  L 616 (-4.4A) None LFA  L 616 ( 4.1A) None None	1.30A	3fw1A-3rkoL: undetectable	3fw1A-3rkoL: 16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G4L_A_ROFA901_0 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 12	MET L 432 TYR L 102 ILE L 353 MET L 243 SER L 250	None	1.37A	3g4lA-3rkoL: undetectable	3g4lA-3rkoL: 21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GWV_A_RFXA801_1 (TRANSPORTER)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K (Escherichia coli)	5 / 12	LEU K  10 GLY K   7 GLN K   5 ILE K  13 LEU J 104	None	0.90A	3gwvA-3rkoK: undetectable	3gwvA-3rkoK: 12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GWV_A_RFXA801_1 (TRANSPORTER)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	LEU K  35 GLY K  34 LEU K  32 ILE N 161 LEU L 591	None	0.91A	3gwvA-3rkoK: undetectable	3gwvA-3rkoK: 12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GWW_A_SFXA801_1 (TRANSPORTER)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K (Escherichia coli)	5 / 12	LEU J  54 GLY J  52 ILE K  66 PHE J  43 ALA J  60	None	1.07A	3gwwA-3rkoJ: 2.6	3gwwA-3rkoJ: 17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCR_A_CHDA4_0 (FERROCHELATASE, MITOCHONDRIAL)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	3 / 3	LEU N 139 PRO N 138 LEU N 142	None	0.39A	3hcrA-3rkoN: undetectable	3hcrA-3rkoN: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K9F_H_LFXH0_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 6	ARG K  85 ARG J 160 GLY J 159 GLU N 104	None	1.07A	3k9fA-3rkoK: 2.4 3k9fB-3rkoK: 2.4 3k9fD-3rkoK: undetectable	3k9fA-3rkoK: 13.13 3k9fB-3rkoK: 13.13 3k9fD-3rkoK: 18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_B_TFPB201_1 (PROTEIN S100-A4)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 8	GLY L 145 PHE L 183 PHE L 186 PHE M 408	None	0.99A	3ko0B-3rkoL: undetectable 3ko0J-3rkoL: undetectable	3ko0B-3rkoL: 8.96 3ko0J-3rkoL: 8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_D_TFPD201_1 (PROTEIN S100-A4)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 8	GLY L 145 PHE L 183 PHE L 186 PHE M 408	None	1.07A	3ko0D-3rkoL: undetectable 3ko0E-3rkoL: undetectable	3ko0D-3rkoL: 8.96 3ko0E-3rkoL: 8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_O_TFPO201_1 (PROTEIN S100-A4)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 8	GLY M  24 PHE N 366 GLY M 114 PHE M 115	None	0.97A	3ko0O-3rkoM: undetectable 3ko0Q-3rkoM: undetectable	3ko0O-3rkoM: 11.37 3ko0Q-3rkoM: 11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_Q_TFPQ201_1 (PROTEIN S100-A4)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 8	PHE L 437 GLY L 367 ILE L 304 PHE L 430	None	0.86A	3ko0O-3rkoL: undetectable 3ko0Q-3rkoL: 0.9	3ko0O-3rkoL: 8.96 3ko0Q-3rkoL: 8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_Q_TFPQ201_1 (PROTEIN S100-A4)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 8	GLY L 224 PHE L 180 ILE L 187 PHE M 427	None	0.89A	3ko0O-3rkoL: undetectable 3ko0Q-3rkoL: 0.9	3ko0O-3rkoL: 8.96 3ko0Q-3rkoL: 8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KU1_A_SAMA226_0 (SAM-DEPENDENT METHYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli; Escherichia coli)	5 / 12	LEU N 176 PRO K   3 GLY J   9 ALA K  12 ILE J  13	None	0.92A	3ku1A-3rkoN: undetectable	3ku1A-3rkoN: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KU1_C_SAMC226_0 (SAM-DEPENDENT METHYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli; Escherichia coli)	5 / 12	LEU N 176 PRO K   3 GLY J   9 ALA K  12 ILE J  13	None	0.90A	3ku1C-3rkoN: undetectable	3ku1C-3rkoN: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KU1_G_SAMG226_0 (SAM-DEPENDENT METHYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli; Escherichia coli)	5 / 12	LEU N 176 PRO K   3 GLY J   9 ALA K  12 ILE J  13	None	0.90A	3ku1G-3rkoN: undetectable	3ku1G-3rkoN: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KU1_H_SAMH226_0 (SAM-DEPENDENT METHYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli; Escherichia coli)	5 / 12	LEU N 176 PRO K   3 GLY J   9 ALA K  12 ILE J  13	None	0.94A	3ku1H-3rkoN: undetectable	3ku1H-3rkoN: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L35_H_DHIH3_0 (GP41 N-PEPTIDE HIV ENTRY INHIBITOR PIE12)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT A (Escherichia coli)	3 / 3	LEU A  85 TRP A  88 GLY A  99	None	0.75A	3l35A-3rkoA: undetectable 3l35H-3rkoA: undetectable	3l35A-3rkoA: 17.74 3l35H-3rkoA: 6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L35_K_DHIK3_0 (GP41 N-PEPTIDE HIV ENTRY INHIBITOR PIE12)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT A (Escherichia coli)	3 / 3	LEU A  85 TRP A  88 GLY A  99	None	0.80A	3l35B-3rkoA: undetectable 3l35K-3rkoA: undetectable	3l35B-3rkoA: 17.74 3l35K-3rkoA: 6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LBD_A_9CRA424_1 (RETINOIC ACID RECEPTOR GAMMA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	PHE N 172 ALA K  12 LEU J 104 ALA N 205 ILE J 111	None	1.30A	3lbdA-3rkoN: undetectable	3lbdA-3rkoN: 19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LD6_B_KKKB602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 12	PHE L 208 TYR L 189 GLY M 340 ALA M 337 THR M 332	None	1.45A	3ld6B-3rkoL: undetectable	3ld6B-3rkoL: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MDV_B_CL6B506_1 (CHOLESTEROL 24-HYDROXYLASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT A NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	VAL A  80 LEU N 137 ALA K  70 GLU K  72 ALA K  65	None	0.91A	3mdvB-3rkoA: undetectable	3mdvB-3rkoA: 16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N8X_A_NIMA701_2 (PROSTAGLANDIN G/H SYNTHASE 1)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	3 / 3	VAL N  23 SER N  27 LEU N  40	None	0.72A	3n8xA-3rkoN: undetectable	3n8xA-3rkoN: 24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NDI_A_SAMA601_0 (METHYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT A NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K (Escherichia coli; Escherichia coli; Escherichia coli)	5 / 12	TYR J  59 ILE A  77 PHE A  75 PHE A  74 ALA K  71	None	1.22A	3ndiA-3rkoJ: undetectable	3ndiA-3rkoJ: 20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O1C_A_ADNA127_1 (HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 10	ILE M 298 PHE M 325 ILE M 328 ILE M 424 LEU M 411	None	1.01A	3o1cA-3rkoM: undetectable	3o1cA-3rkoM: 13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O7W_A_SAMA801_0 (LEUCINE CARBOXYL METHYLTRANSFERASE 1)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli; Escherichia coli)	5 / 12	ALA J 110 GLY N 208 GLY N 206 PHE N 169 VAL L 605	None	1.10A	3o7wA-3rkoJ: undetectable	3o7wA-3rkoJ: 18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OAP_A_9CRA500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ILE N 250 ALA N 249 LEU N 119 ALA N 120 LEU N 306	None	0.85A	3oapA-3rkoN: undetectable	3oapA-3rkoN: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXW_D_017D200_2 (HIV-1 PROTEASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 10	LEU M   6 VAL M 127 GLY M  98 VAL M  99 ILE M 128	None	1.01A	3oxwD-3rkoM: undetectable	3oxwD-3rkoM: 10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXW_D_017D200_2 (HIV-1 PROTEASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 10	LEU M   6 VAL M 127 VAL M  99 VAL M  91 ILE M 128	None	0.89A	3oxwD-3rkoM: undetectable	3oxwD-3rkoM: 10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXX_A_DR7A100_1 (HIV-1 PROTEASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 12	LEU M   6 VAL M 127 GLY M  98 VAL M  99 ILE M 128	None	0.92A	3oxxA-3rkoM: undetectable	3oxxA-3rkoM: 10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PFG_A_SAMA264_0 (N-METHYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 12	ALA L 385 GLY L 395 LEU L 389 PHE L 340 SER L 464	None None None LFA  L 616 (-4.4A) None	1.34A	3pfgA-3rkoL: undetectable	3pfgA-3rkoL: 18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PO7_A_ZONA601_1 (AMINE OXIDASE [FLAVIN-CONTAINING] B)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 8	LEU N 184 GLN K  55 TYR N 178 TYR J 137	None	1.18A	3po7A-3rkoN: undetectable	3po7A-3rkoN: 21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q1E_C_T44C128_1 (5-HYDROXYISOURATE HYDROLASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 6	LEU M 147 PRO N 387 LEU M 186 LEU M 183	None	0.75A	3q1eA-3rkoM: undetectable 3q1eC-3rkoM: undetectable	3q1eA-3rkoM: 11.39 3q1eC-3rkoM: 11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	LEU K  68 LEU N 134 ILE K  75 GLY J 151 LEU J 148	None	1.12A	3q95A-3rkoK: undetectable	3q95A-3rkoK: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QGZ_A_ADNA127_1 (HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 1)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 10	ILE M 298 PHE M 325 ILE M 328 ILE M 424 LEU M 411	None	1.00A	3qgzA-3rkoM: undetectable	3qgzA-3rkoM: 13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TBG_B_RTZB1_1 (CYTOCHROME P450 2D6)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 12	LEU L 461 GLY L 383 LEU L 386 PHE L 379 ALA L 348	None	1.10A	3tbgB-3rkoL: undetectable	3tbgB-3rkoL: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_B_CLMB221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	5 / 12	SER N  84 PHE N 241 SER N  41 VAL J 153 VAL N  21	None	1.31A	3u9fB-3rkoN: undetectable 3u9fC-3rkoN: undetectable	3u9fB-3rkoN: 20.04 3u9fC-3rkoN: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_C_CLMC221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	5 / 11	PHE N 105 SER N  84 PHE N 241 SER N  41 VAL J 153	None	1.49A	3u9fA-3rkoN: undetectable 3u9fC-3rkoN: undetectable	3u9fA-3rkoN: 20.04 3u9fC-3rkoN: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_E_CLME221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	5 / 10	SER N  84 PHE N 241 SER N  41 VAL J 153 VAL N  21	None	1.38A	3u9fE-3rkoN: undetectable	3u9fE-3rkoN: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_F_CLMF221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	5 / 10	SER N  84 PHE N 241 SER N  41 VAL J 153 VAL N  21	None	1.40A	3u9fD-3rkoN: 0.0 3u9fF-3rkoN: 0.0	3u9fD-3rkoN: 20.04 3u9fF-3rkoN: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_H_CLMH221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	5 / 12	SER N  84 PHE N 241 SER N  41 VAL J 153 VAL N  21	None	1.36A	3u9fH-3rkoN: undetectable 3u9fI-3rkoN: undetectable	3u9fH-3rkoN: 20.04 3u9fI-3rkoN: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_J_CLMJ221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	5 / 12	SER N  84 PHE N 241 SER N  41 VAL J 153 VAL N  21	None	1.32A	3u9fJ-3rkoN: undetectable 3u9fK-3rkoN: undetectable	3u9fJ-3rkoN: 20.04 3u9fK-3rkoN: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_K_CLMK221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	5 / 10	SER N  84 PHE N 241 SER N  41 VAL J 153 VAL N  21	None	1.31A	3u9fK-3rkoN: undetectable	3u9fK-3rkoN: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_O_CLMO221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	5 / 11	SER N  84 PHE N 241 SER N  41 VAL J 153 VAL N  21	None	1.34A	3u9fM-3rkoN: undetectable 3u9fO-3rkoN: undetectable	3u9fM-3rkoN: 20.04 3u9fO-3rkoN: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U9F_R_CLMR221_0 (CHLORAMPHENICOL ACETYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	5 / 10	SER N  84 PHE N 241 SER N  41 VAL J 153 VAL N  21	None	1.31A	3u9fR-3rkoN: undetectable	3u9fR-3rkoN: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VHU_A_SNLA1001_2 (MINERALOCORTICOID RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 5	LEU N  79 LEU N  82 LEU N 338 SER N 336	LFA  N 488 ( 4.8A) None None None	1.03A	3vhuA-3rkoN: 1.4	3vhuA-3rkoN: 19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WXO_A_NIZA802_1 (CATALASE-PEROXIDASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 8	LEU M 276 ASN M 495 GLY M 494 ILE M 493	None	0.90A	3wxoA-3rkoM: undetectable	3wxoA-3rkoM: 20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A83_A_DXCA1160_0 (MAJOR POLLEN ALLERGEN BET V 1-A)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 12	PRO M  10 LEU M 124 ILE M 128 ALA M  41 SER M  43	None	1.20A	4a83A-3rkoM: undetectable	4a83A-3rkoM: 15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_I_ZPCI1318_2 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 6	GLU M 108 ILE M 109 HIS N 435 VAL N 430	None	1.15A	4a97I-3rkoM: 4.0	4a97I-3rkoM: 21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AQ7_A_LEUA902_0 (LEUCINE--TRNA LIGASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 7	LEU M 355 SER M 351 HIS M 322 HIS M 348	None	1.27A	4aq7A-3rkoM: 3.4	4aq7A-3rkoM: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4D7B_A_TCWA1126_1 (TRANSTHYRETIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 6	LEU L 347 LEU L 457 SER L 454 THR L 452	None	1.20A	4d7bB-3rkoL: undetectable	4d7bB-3rkoL: 12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EIL_C_FOLC703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 11	VAL N 253 SER N 246 PHE N 216 LEU N 218 VAL N 254	None	1.36A	4eilC-3rkoN: undetectable	4eilC-3rkoN: 22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EQ4_A_SALA601_1 (4-SUBSTITUTED BENZOATES-GLUTAMATE LIGASE GH3.12)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 7	LEU M 211 TYR M 207 ILE M 496 GLY M  59	None	0.92A	4eq4A-3rkoM: undetectable	4eq4A-3rkoM: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EQL_A_SALA602_1 (4-SUBSTITUTED BENZOATES-GLUTAMATE LIGASE GH3.12)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 7	LEU M 211 TYR M 207 ILE M 496 GLY M  59	None	0.90A	4eqlA-3rkoM: undetectable	4eqlA-3rkoM: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EQL_B_SALB602_1 (4-SUBSTITUTED BENZOATES-GLUTAMATE LIGASE GH3.12)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 7	LEU M 211 TYR M 207 ILE M 496 GLY M  59	None	0.90A	4eqlB-3rkoM: undetectable	4eqlB-3rkoM: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F8Y_A_VK3A202_1 (NADPH QUINONE OXIDOREDUCTASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 5	ARG J 160 TYR N  98 TYR N 145 LEU N  95	None	1.37A	4f8yA-3rkoJ: undetectable 4f8yB-3rkoJ: undetectable	4f8yA-3rkoJ: 25.33 4f8yB-3rkoJ: 25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F8Y_B_VK3B202_1 (NADPH QUINONE OXIDOREDUCTASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 6	ARG J 160 TYR N  98 TYR N 145 LEU N  95	None	1.46A	4f8yA-3rkoJ: undetectable 4f8yB-3rkoJ: undetectable	4f8yA-3rkoJ: 25.33 4f8yB-3rkoJ: 25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F8Y_C_VK3C202_1 (NADPH QUINONE OXIDOREDUCTASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 7	ARG J 160 TYR N  98 TYR N 145 LEU N  95	None	1.37A	4f8yC-3rkoJ: undetectable 4f8yD-3rkoJ: undetectable	4f8yC-3rkoJ: 25.33 4f8yD-3rkoJ: 25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_A_HFGA1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli; Escherichia coli)	5 / 12	PHE L 171 VAL L 176 GLU M 407 HIS M 322 THR M 401	None	1.16A	4hvcA-3rkoL: undetectable	4hvcA-3rkoL: 21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_B_HFGB1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli; Escherichia coli)	5 / 12	PHE L 171 VAL L 176 GLU M 407 HIS M 322 THR M 401	None	1.19A	4hvcB-3rkoL: undetectable	4hvcB-3rkoL: 21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J24_C_ESTC600_1 (ESTROGEN RECEPTOR BETA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K (Escherichia coli)	5 / 12	MET K  38 LEU K  35 ILE K  24 ILE J  20 LEU K  19	None	1.32A	4j24C-3rkoK: undetectable	4j24C-3rkoK: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JUO_F_LFXF101_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B E-SITE DNA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K (Escherichia coli)	3 / 4	SER J 100 GLY K  34 GLU K  72	None	0.61A	4juoA-3rkoJ: undetectable 4juoC-3rkoJ: undetectable	4juoA-3rkoJ: 17.17 4juoC-3rkoJ: 14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KOE_H_TR6H101_1 (DNA TOPOISOMERASE 4 SUBUNIT A DNA TOPOISOMERASE 4 SUBUNIT B E-SITE DNA4)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 7	SER M 489 GLY M 402 GLY M 406 GLU M 407	None	0.90A	4koeA-3rkoM: undetectable 4koeB-3rkoM: undetectable 4koeD-3rkoM: undetectable	4koeA-3rkoM: 21.18 4koeB-3rkoM: 21.18 4koeD-3rkoM: 18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KT0_A_PQNA2001_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 PHOTOSYSTEM I REACTION CENTER SUBUNIT IX)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 11	GLY N 394 LEU N 330 GLY N 327 ILE N 132 LEU N 170	None	1.07A	4kt0A-3rkoN: undetectable 4kt0J-3rkoN: undetectable	4kt0A-3rkoN: 23.62 4kt0J-3rkoN: 6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L39_A_SALA602_1 (4-SUBSTITUTED BENZOATES-GLUTAMATE LIGASE GH3.12)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 6	LEU M 211 TYR M 207 ILE M 496 GLY M  59	None	0.86A	4l39A-3rkoM: 1.0	4l39A-3rkoM: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L39_B_SALB601_1 (4-SUBSTITUTED BENZOATES-GLUTAMATE LIGASE GH3.12)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 7	LEU M 211 TYR M 207 ILE M 496 GLY M  59	None	0.85A	4l39B-3rkoM: undetectable	4l39B-3rkoM: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LTW_A_STRA301_1 (ANCESTRAL STEROID RECEPTOR 2)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	LEU N  79 LEU N  82 LEU N  85 ALA N  86 LEU N 463	LFA  N 488 ( 4.8A) None None None None	0.64A	4ltwA-3rkoN: undetectable	4ltwA-3rkoN: 20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OK1_A_198A1001_1 (ANDROGEN RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 12	LEU M 186 LEU M 183 GLY M 182 LEU M 147 VAL M 130	None	1.15A	4ok1A-3rkoM: undetectable	4ok1A-3rkoM: 18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OLF_A_HFGA802_0 (PROLINE--TRNA LIGASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli; Escherichia coli)	5 / 12	PHE L 171 VAL L 176 GLU M 407 HIS M 322 THR M 401	None	1.11A	4olfA-3rkoL: undetectable	4olfA-3rkoL: 20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OR0_B_NPSB603_1 (SERUM ALBUMIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 11	LEU M 120 VAL M 257 LEU M  97 LEU M 153 LEU M 124	None	1.27A	4or0B-3rkoM: 3.1	4or0B-3rkoM: 19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P6X_A_HCYA900_1 (GLUCOCORTICOID RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 12	MET L 432 GLY L 366 GLN L 442 ILE L 433 PHE L 437	None	1.35A	4p6xA-3rkoL: 2.1	4p6xA-3rkoL: 17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P6X_G_HCYG900_2 (GLUCOCORTICOID RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	3 / 3	LEU M 190 MET M 136 TYR M 197	None	0.85A	4p6xG-3rkoM: 1.9	4p6xG-3rkoM: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P6X_I_HCYI900_2 (GLUCOCORTICOID RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	3 / 3	MET N 376 MET N 388 TYR N 425	None	0.90A	4p6xI-3rkoN: undetectable	4p6xI-3rkoN: 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PTH_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	3 / 3	ASP M 135 LEU M 138 PHE M 137	None	0.66A	4pthA-3rkoM: undetectable	4pthA-3rkoM: 14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R29_C_SAMC301_0 (UNCHARACTERIZED PROTEIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli; Escherichia coli)	5 / 12	ALA N 164 SER N 163 ALA J 155 GLY K  76 GLU K  36	None	1.14A	4r29C-3rkoN: 2.8	4r29C-3rkoN: 17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R38_A_RBFA201_2 (BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K (Escherichia coli)	4 / 8	ASN K  27 LEU K  32 VAL J  71 LEU J  74	None	0.80A	4r38A-3rkoK: undetectable	4r38A-3rkoK: 20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RET_A_DGXA1107_1 (SODIUM/POTASSIUM-TRA NSPORTING ATPASE SUBUNIT ALPHA-1)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 12	LEU L 389 LEU L 291 GLY L 395 PHE L 341 LEU L 345	None	1.24A	4retA-3rkoL: 2.4	4retA-3rkoL: 21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RET_C_DGXC2005_1 (SODIUM/POTASSIUM-TRA NSPORTING ATPASE SUBUNIT ALPHA-1)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 12	LEU L 389 LEU L 291 GLY L 395 PHE L 341 LEU L 345	None	1.24A	4retC-3rkoL: undetectable	4retC-3rkoL: 21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RYA_A_MTLA501_0 (ABC TRANSPORTER SUBSTRATE BINDING PROTEIN (SORBITOL))	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	GLY N 412 ALA N 413 ALA N 274 VAL N 271 TRP N 409	LFA  N 489 ( 3.7A) None None None None	1.40A	4ryaA-3rkoN: undetectable	4ryaA-3rkoN: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_A_032A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 5	ILE L 372 VAL L 375 PHE L 346 HIS L 446	None	1.38A	4rzvA-3rkoL: 1.6	4rzvA-3rkoL: 19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U15_A_0HKA2001_2 (MUSCARINIC ACETYLCHOLINE RECEPTOR M3,LYSOZYME,MUSCARIN IC ACETYLCHOLINE RECEPTOR M3)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	3 / 3	ASN N 101 PHE N 105 TYR N  92	None None LFA  N 487 (-4.6A)	0.89A	4u15A-3rkoN: 2.9	4u15A-3rkoN: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UCI_A_SAMA2409_0 (RNA-DIRECTED RNA POLYMERASE L)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	GLY N 385 GLY N 391 GLY N 394 LEU N 381 ALA N 384	None	0.93A	4uciA-3rkoN: undetectable	4uciA-3rkoN: 23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UCI_B_SAMB2409_0 (RNA-DIRECTED RNA POLYMERASE L)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	GLY N 385 GLY N 391 GLY N 394 LEU N 381 ALA N 384	None	0.93A	4uciB-3rkoN: undetectable	4uciB-3rkoN: 23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UCK_A_SAMA2409_0 (RNA-DIRECTED RNA POLYMERASE L)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	GLY N 385 GLY N 391 GLY N 394 LEU N 381 ALA N 384	None	0.91A	4uckA-3rkoN: undetectable	4uckA-3rkoN: 23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4URO_D_NOVD2000_1 (DNA GYRASE SUBUNIT B)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ASN N 285 PRO N 228 ASP N 229 ILE N 303 ARG N 296	None	1.35A	4uroD-3rkoN: undetectable	4uroD-3rkoN: 17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4USW_A_ACTA1470_0 (ADENYLATE CYCLASE TYPE 10)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 6	LEU L  84 LEU L 132 VAL L 131 ARG L 268	None	1.19A	4uswA-3rkoL: undetectable	4uswA-3rkoL: 20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 11	LEU L 461 GLY L 383 LEU L 386 PHE L 379 ALA L 348	None	1.11A	4wnuA-3rkoL: 2.8	4wnuA-3rkoL: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_C_QDNC602_1 (CYTOCHROME P450 2D6)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 11	LEU L 461 GLY L 383 LEU L 386 PHE L 379 ALA L 348	None	1.12A	4wnuC-3rkoL: 1.1	4wnuC-3rkoL: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNW_A_RTZA602_1 (CYTOCHROME P450 2D6)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	PHE N 207 GLY N 215 LEU N 214 VAL N 254 VAL N 177	None	1.03A	4wnwA-3rkoN: 0.0	4wnwA-3rkoN: 23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XI3_A_29SA601_1 (ESTROGEN RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 12	THR L 247 ALA L 251 LEU L 252 LEU L 344 HIS L 453	None	1.27A	4xi3A-3rkoL: undetectable	4xi3A-3rkoL: 18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XI3_D_29SD601_1 (ESTROGEN RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 12	THR L 247 ALA L 251 LEU L 252 LEU L 344 HIS L 453	None	1.26A	4xi3D-3rkoL: undetectable	4xi3D-3rkoL: 18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y4D_A_CFFA411_1 (ENDOTHIAPEPSIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 6	LEU N 170 LEU K  68 PHE N 129 ILE N 135	None	1.04A	4y4dA-3rkoN: undetectable	4y4dA-3rkoN: 23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4F_A_IPHA902_0 (PROTEIN ARGONAUTE-2)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 7	LEU M 244 LYS M 234 PRO M 236 LEU M 259	None	0.98A	4z4fA-3rkoM: undetectable	4z4fA-3rkoM: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZBR_A_NPSA603_1 (SERUM ALBUMIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 10	ALA M 394 LEU M 478 ALA M 347 LEU M 355 ALA M 352	None	1.14A	4zbrA-3rkoM: undetectable	4zbrA-3rkoM: 21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZN7_B_DESB600_1 (ESTROGEN RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 11	MET K  61 LEU K  64 LEU N 118 LEU N 134 HIS N 124	None	1.30A	4zn7B-3rkoK: undetectable	4zn7B-3rkoK: 18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DLV_A_5D5A930_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 12	LEU M 132 ILE M 123 PHE M 131 ARG M 273 TYR M 269	None	1.37A	5dlvA-3rkoM: undetectable	5dlvA-3rkoM: 19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ECK_A_ILEA601_0 (JASMONIC ACID-AMIDO SYNTHETASE JAR1)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 6	ALA L  42 THR L  45 VAL L  44 VAL L 128	None	1.02A	5eckA-3rkoL: undetectable	5eckA-3rkoL: 22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ECK_D_ILED601_0 (JASMONIC ACID-AMIDO SYNTHETASE JAR1)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 6	ALA L  42 THR L  45 VAL L  44 VAL L 128	None	1.03A	5eckD-3rkoL: undetectable	5eckD-3rkoL: 22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ECL_D_ILED602_0 (JASMONIC ACID-AMIDO SYNTHETASE JAR1)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 6	ILE L 332 ALA L 339 VAL L  91 VAL L 263 HIS L 338	None	1.21A	5eclD-3rkoL: undetectable	5eclD-3rkoL: 22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EVY_X_SALX502_1 (SALICYLATE HYDROXYLASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 5	SER M 105 MET M 150 LEU M 153 PHE M 116	None	1.28A	5evyX-3rkoM: 1.1	5evyX-3rkoM: 22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FHZ_A_REAA602_1 (ALDEHYDE DEHYDROGENASE FAMILY 1 MEMBER A3)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	GLY N 141 PHE N 105 LEU N 108 CYH N  88 THR N  87	None	1.39A	5fhzA-3rkoN: undetectable	5fhzA-3rkoN: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FSA_A_X2NA590_1 (CYP51 VARIANT1)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ALA K  69 LEU K  19 ILE J 102 GLY L 601 LEU N 209	None	1.22A	5fsaA-3rkoK: 2.3	5fsaA-3rkoK: 11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FSA_B_X2NB590_1 (CYP51 VARIANT1)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 12	GLY M 413 GLN M 416 LEU M 272 ILE M  83 GLY M  85	None	1.19A	5fsaB-3rkoM: undetectable	5fsaB-3rkoM: 21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HG0_A_SAMA301_0 (PANTOTHENATE SYNTHETASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	GLY N 454 LEU N 346 VAL N 109 GLY N 342 LEU N 458	None	1.25A	5hg0A-3rkoN: undetectable	5hg0A-3rkoN: 18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWK_A_BEZA301_0 (GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOT RANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	5 / 10	GLY L 580 SER L 576 LEU N 286 TYR N 423 TYR N 424	None	1.31A	5hwkA-3rkoL: undetectable	5hwkA-3rkoL: 15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWK_B_BEZB301_0 (GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOT RANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	5 / 10	GLY L 580 SER L 576 LEU N 286 TYR N 423 TYR N 424	None	1.31A	5hwkB-3rkoL: undetectable	5hwkB-3rkoL: 15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HYR_B_ESTB601_1 (ESTROGEN RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 11	LEU K  68 ALA K  65 LEU N 171 LEU N 170 HIS N 124	None	1.46A	5hyrB-3rkoK: undetectable	5hyrB-3rkoK: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I9Y_A_1N1A1001_2 (EPHRIN TYPE-A RECEPTOR 2)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	3 / 3	ILE N 161 ILE K  75 MET K  31	None	0.68A	5i9yA-3rkoN: undetectable	5i9yA-3rkoN: 19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KPC_A_SAMA401_0 (PAVINE N-METHYLTRANSFERASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	GLY N  78 SER N  84 LEU N  85 ALA N  48 LEU N  52	LFA  N 488 ( 3.8A) None None None None	0.89A	5kpcA-3rkoN: undetectable	5kpcA-3rkoN: 21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L1F_C_6ZPC902_1 (GLUTAMATE RECEPTOR 2)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 7	ASP N 229 PRO N 228 TYR N 300 SER L 597	None	1.20A	5l1fC-3rkoN: 2.7	5l1fC-3rkoN: 22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L4I_B_6J3B201_0 (TRANSTHYRETIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 6	LEU L 347 LEU L 457 SER L 454 THR L 452	None	1.15A	5l4iB-3rkoL: undetectable	5l4iB-3rkoL: 11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L5F_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-8,PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 8	THR N 244 SER N 302 SER N 301 ALA N 340	None	1.13A	5l5fY-3rkoN: undetectable 5l5fZ-3rkoN: undetectable	5l5fY-3rkoN: 19.38 5l5fZ-3rkoN: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MUG_A_VIVA301_1 (ALPHA-TOCOPHEROL TRANSFER PROTEIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	3 / 3	SER N 302 SER N 219 PHE N 341	None	0.86A	5mugA-3rkoN: undetectable	5mugA-3rkoN: 18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ODH_G_ACTG710_0 (HETERODISULFIDE REDUCTASE, SUBUNIT A)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT A NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli; Escherichia coli)	4 / 4	ARG J 160 ILE A 120 TYR A 116 ILE N  28	None	0.88A	5odhG-3rkoJ: undetectable	5odhG-3rkoJ: 14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5T7B_A_IPHA902_0 (PROTEIN ARGONAUTE-2)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 7	LEU M 244 LYS M 234 PRO M 236 LEU M 259	None	1.00A	5t7bA-3rkoM: undetectable	5t7bA-3rkoM: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5U6N_A_SALA505_1 (UDP-GLYCOSYLTRANSFER ASE 74F2)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 8	SER L 398 HIS L 334 GLN L 315 THR L 425	None	1.14A	5u6nA-3rkoL: undetectable	5u6nA-3rkoL: 21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5U6N_B_SALB504_1 (UDP-GLYCOSYLTRANSFER ASE 74F2)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 6	SER L 398 HIS L 334 GLN L 315 THR L 425	None	1.12A	5u6nB-3rkoL: undetectable	5u6nB-3rkoL: 21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UAN_A_9CRA503_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ILE N 250 ALA N 249 LEU N 119 ALA N 120 LEU N 306	None	0.89A	5uanA-3rkoN: undetectable	5uanA-3rkoN: 21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UMW_B_RBFB201_1 (GLYOXALASE/BLEOMYCIN RESISANCE PROTEIN/DIOXYGENASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 7	VAL N 328 ARG M  74 GLU N 324 LEU M 190	None	1.20A	5umwB-3rkoN: undetectable 5umwE-3rkoN: undetectable	5umwB-3rkoN: 9.73 5umwE-3rkoN: 9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5V0V_A_8QPA613_1 (SERUM ALBUMIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K (Escherichia coli)	4 / 8	ALA K  45 VAL K  48 PHE J   5 GLY K   7	None	0.93A	5v0vA-3rkoK: 4.6	5v0vA-3rkoK: 11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VCE_A_RITA602_1 (CYTOCHROME P450 3A4)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K (Escherichia coli)	5 / 12	SER J  40 ILE J  56 ALA J  12 THR J  16 ILE K  37	None	1.01A	5vceA-3rkoJ: undetectable	5vceA-3rkoJ: 16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VW5_A_NCAA403_0 (FERREDOXIN--NADP REDUCTASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 8	GLY L 284 GLY L 324 LEU L 323 ALA L 327	None	0.73A	5vw5A-3rkoL: undetectable	5vw5A-3rkoL: 18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VYH_A_FOLA409_0 (S PROTEIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	5 / 10	PRO K   3 HIS K   6 ALA N 179 GLY N 206 ALA K  45	None	1.05A	5vyhA-3rkoK: undetectable	5vyhA-3rkoK: 14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W7B_B_PA1B204_1 (ACYLOXYACYL HYDROLASE SMALL SUBUNIT ACYLOXYACYL HYDROLASE LARGE SUBUNIT)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	3 / 3	GLY M 242 ASN L 566 ARG M 313	None	0.67A	5w7bD-3rkoM: undetectable	5w7bD-3rkoM: 8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_B_HFGB802_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli; Escherichia coli)	5 / 12	PHE L 171 VAL L 176 GLU M 407 HIS M 322 THR M 401	None	1.10A	5xioB-3rkoL: undetectable	5xioB-3rkoL: 21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli; Escherichia coli)	5 / 12	PHE L 171 VAL L 176 GLU M 407 HIS M 322 THR M 401	None	1.09A	5xiqA-3rkoL: undetectable	5xiqA-3rkoL: 20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_B_HFGB1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli; Escherichia coli)	5 / 12	PHE L 171 VAL L 176 GLU M 407 HIS M 322 THR M 401	None	1.08A	5xiqB-3rkoL: undetectable	5xiqB-3rkoL: 20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_B_HFGB1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli; Escherichia coli)	5 / 12	VAL L 172 ARG L 175 GLU M 407 HIS M 322 THR M 401	LFA  L 614 ( 4.8A) None None None None	1.36A	5xiqB-3rkoL: undetectable	5xiqB-3rkoL: 20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_C_HFGC1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli; Escherichia coli)	5 / 12	PHE L 171 VAL L 176 GLU M 407 HIS M 322 THR M 401	None	1.12A	5xiqC-3rkoL: undetectable	5xiqC-3rkoL: 20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_D_HFGD1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli; Escherichia coli)	5 / 12	PHE L 171 VAL L 176 GLU M 407 HIS M 322 THR M 401	None	1.12A	5xiqD-3rkoL: undetectable	5xiqD-3rkoL: 20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YOD_F_BEZF201_0 (NS3 PROTEASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 5	HIS N  34 ALA N  91 TYR N  98 TYR N 145	None	1.32A	5yodF-3rkoN: undetectable	5yodF-3rkoN: 15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z12_B_9CRB501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ILE N 250 ALA N 249 LEU N 119 ALA N 120 LEU N 306	None	0.88A	5z12B-3rkoN: undetectable	5z12B-3rkoN: 9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z12_C_9CRC501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ILE N 250 ALA N 249 LEU N 119 ALA N 120 LEU N 306	None	0.86A	5z12C-3rkoN: undetectable	5z12C-3rkoN: 9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A5Y_D_9CRD501_0 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ILE N 250 ALA N 249 LEU N 119 ALA N 120 LEU N 306	None	0.89A	6a5yD-3rkoN: undetectable	6a5yD-3rkoN: 10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A5Z_L_9CRL501_0 (RETINOIC ACID RECEPTOR RXR-ALPHA)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	5 / 12	ILE N 250 ALA N 249 LEU N 119 ALA N 120 LEU N 306	None	0.97A	6a5zL-3rkoN: undetectable	6a5zL-3rkoN: 10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A7P_A_9SCA601_0 (SERUM ALBUMIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 12	ILE L 353 PHE L 437 LEU L 389 LEU L 308 PHE L 341	None	1.18A	6a7pA-3rkoL: 2.5	6a7pA-3rkoL: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A7P_A_9SCA601_0 (SERUM ALBUMIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 12	LEU L 403 ILE L 402 LEU L 506 GLY L 395 PHE L 423	None	1.23A	6a7pA-3rkoL: 2.5	6a7pA-3rkoL: 19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A7P_A_9SCA601_0 (SERUM ALBUMIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT A NADH-QUINONE OXIDOREDUCTASE SUBUNIT J (Escherichia coli; Escherichia coli)	5 / 12	LEU J  32 ILE J  33 LEU J 147 GLY J  61 CYH A  27	None	1.12A	6a7pA-3rkoJ: 4.5	6a7pA-3rkoJ: 13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AYC_A_1YNA502_1 (PROTEIN CYP51)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 12	ALA L 404 ALA L 343 ALA L 256 THR L 260 LEU L 335	None	1.36A	6aycA-3rkoL: undetectable	6aycA-3rkoL: 8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AYC_A_1YNA502_1 (PROTEIN CYP51)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	5 / 12	ALA L 406 ALA L 343 ALA L 256 THR L 260 LEU L 335	None	1.13A	6aycA-3rkoL: undetectable	6aycA-3rkoL: 8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BRD_A_RFPA502_1 (RIFAMPIN MONOOXYGENASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	5 / 12	LEU M 471 ARG M 463 PHE M 391 GLY M 360 MET M 460	None	1.39A	6brdA-3rkoM: undetectable	6brdA-3rkoM: 10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C2M_A_SUEA1202_0 (NS3 PROTEASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli; Escherichia coli)	5 / 12	VAL K  60 ILE J 111 GLY N 206 PHE N 172 ALA K  45	None	1.10A	6c2mA-3rkoK: undetectable	6c2mA-3rkoK: 20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C2M_B_SUEB1202_0 (NS3 PROTEASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli; Escherichia coli)	5 / 12	VAL K  60 ILE J 111 GLY N 206 PHE N 172 ALA K  45	None	1.13A	6c2mB-3rkoK: undetectable	6c2mB-3rkoK: 20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C2M_D_SUED1202_0 (NS3 PROTEASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT J NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli; Escherichia coli)	5 / 12	VAL K  60 ILE J 111 GLY N 206 PHE N 172 ALA K  45	None	0.99A	6c2mD-3rkoK: undetectable	6c2mD-3rkoK: 20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDU_G_EY4G501_0 (CHIMERIC ALPHA1GABAA RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	5 / 7	ILE N 475 GLN N 472 TRP M  71 PRO M  73 ILE N 393	None	1.46A	6cduF-3rkoN: 1.5 6cduG-3rkoN: 4.4	6cduF-3rkoN: 21.84 6cduG-3rkoN: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDU_G_EY4G502_0 (CHIMERIC ALPHA1GABAA RECEPTOR)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	4 / 8	ILE N 475 GLN N 472 TRP N 470 PRO M  73	None	1.07A	6cduG-3rkoN: 4.4 6cduH-3rkoN: undetectable	6cduG-3rkoN: 21.84 6cduH-3rkoN: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6D9K_F_ACTF802_0 (UNCHARACTERIZED PROTEIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	3 / 3	TYR N 159 ALA N 234 LEU N 242	None	0.75A	6d9kF-3rkoN: undetectable	6d9kF-3rkoN: 21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DM2_B_CYZB1302_0 (GLUTAMATE RECEPTOR 2,VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	5 / 10	SER K  42 LEU N 214 LEU N 209 ILE N 132 SER N 168	None	1.43A	6dm2B-3rkoK: 4.3 6dm2C-3rkoK: 5.6	6dm2B-3rkoK: 20.41 6dm2C-3rkoK: 20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DM2_D_CYZD1302_0 (GLUTAMATE RECEPTOR 2,VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT K NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli; Escherichia coli)	5 / 10	ILE N 132 SER N 168 SER K  42 LEU N 214 LEU N 209	None	1.43A	6dm2A-3rkoN: 4.4 6dm2D-3rkoN: 3.6	6dm2A-3rkoN: 10.46 6dm2D-3rkoN: 10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F6J_D_ACTD404_0 (L-LYSINE 3-HYDROXYLASE)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT N (Escherichia coli)	4 / 6	GLN N 439 GLU N 438 HIS N 435 ALA N 436	None	1.34A	6f6jC-3rkoN: undetectable 6f6jD-3rkoN: undetectable	6f6jC-3rkoN: 23.20 6f6jD-3rkoN: 23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HD4_B_STIB602_1 (TYROSINE-PROTEIN KINASE ABL1)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L (Escherichia coli)	4 / 6	LEU L 321 VAL L 502 MET L 407 GLY L 405	None	0.98A	6hd4B-3rkoL: 2.6	6hd4B-3rkoL: 7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT L NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli; Escherichia coli)	5 / 12	PHE L 171 VAL L 176 GLU M 407 HIS M 322 THR M 401	None	1.11A	6mn8A-3rkoL: undetectable	6mn8A-3rkoL: 20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MVX_A_K4DA1304_0 (ION TRANSPORT PROTEIN)	3rko	NADH-QUINONE OXIDOREDUCTASE SUBUNIT M (Escherichia coli)	4 / 6	THR M  94 LEU M  93 THR M  39 LEU M  88	None	0.97A	6mvxA-3rkoM: 1.6 6mvxB-3rkoM: 4.2 6mvxC-3rkoM: 4.0	6mvxA-3rkoM: 21.40 6mvxB-3rkoM: 21.40 6mvxC-3rkoM: 21.40