SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rks'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_A_T98A201_1
(PROGESTERONE
RECEPTOR)		 3rks HYDROXYNITRILASE
(Manihot
esculenta) 		5 / 10 LEU A 106
LEU A 149
LEU A 179
THR A 117
PHE A 215
 None
 1.28A 1zucA-3rksA:
undetectable		 1zucA-3rksA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 3rks HYDROXYNITRILASE
(Manihot
esculenta) 		4 / 4 ARG A  46
ASP A  37
ASP A  44
PRO A  45
 None
 1.28A 3fgrB-3rksA:
undetectable		 3fgrB-3rksA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 3rks HYDROXYNITRILASE
(Manihot
esculenta) 		5 / 12 LEU A 106
HIS A  14
GLY A 177
SER A  41
LEU A  84
 None
 0.99A 3okxA-3rksA:
undetectable		 3okxA-3rksA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 3rks HYDROXYNITRILASE
(Manihot
esculenta) 		5 / 12 LEU A 106
HIS A  14
TYR A  57
SER A  41
LEU A  84
 None
 1.37A 3okxA-3rksA:
undetectable		 3okxA-3rksA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3rks HYDROXYNITRILASE
(Manihot
esculenta) 		5 / 12 LEU A 106
HIS A  14
GLY A 177
SER A  41
LEU A  84
 None
 0.95A 3okxB-3rksA:
undetectable		 3okxB-3rksA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3rks HYDROXYNITRILASE
(Manihot
esculenta) 		5 / 12 LEU A 106
HIS A  14
TYR A  57
SER A  41
LEU A  84
 None
 1.33A 3okxB-3rksA:
undetectable		 3okxB-3rksA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3rks HYDROXYNITRILASE
(Manihot
esculenta) 		5 / 12 LEU A  84
VAL A 118
LEU A 121
ILE A 210
LEU A 153
 None
 1.07A 3w67D-3rksA:
2.2		 3w67D-3rksA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3rks HYDROXYNITRILASE
(Manihot
esculenta) 		4 / 4 ASN A  52
SER A 115
LEU A 184
THR A 140
 None
 1.42A 4an2A-3rksA:
undetectable		 4an2A-3rksA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 3rks HYDROXYNITRILASE
(Manihot
esculenta) 		5 / 12 GLN A 239
GLY A  78
ASN A 104
ILE A  86
LEU A   8
 None
 1.25A 4azsA-3rksA:
2.3		 4azsA-3rksA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 3rks HYDROXYNITRILASE
(Manihot
esculenta) 		5 / 12 GLN A 239
GLY A  78
ASN A 104
ILE A  86
LEU A   8
 None
 1.25A 4azwA-3rksA:
2.5		 4azwA-3rksA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 3rks HYDROXYNITRILASE
(Manihot
esculenta) 		4 / 8 ILE A  75
ILE A 203
PHE A 102
GLY A  83
 None
 0.85A 4hdlA-3rksA:
undetectable		 4hdlA-3rksA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 3rks HYDROXYNITRILASE
(Manihot
esculenta) 		3 / 3 ARG A 129
GLU A 156
ASN A 157
 None
 0.85A 4imaD-3rksA:
3.1		 4imaD-3rksA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 3rks HYDROXYNITRILASE
(Manihot
esculenta) 		3 / 3 ARG A 129
GLU A 156
ASN A 157
 None
 0.88A 4ip7D-3rksA:
2.8		 4ip7D-3rksA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 3rks HYDROXYNITRILASE
(Manihot
esculenta) 		3 / 3 PHE A 190
THR A  11
LEU A 184
 None
 0.76A 4qztA-3rksA:
undetectable		 4qztA-3rksA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3rks HYDROXYNITRILASE
(Manihot
esculenta) 		4 / 8 ILE A  18
LEU A 149
LEU A 153
MET A 174
 None
 0.90A 4xtaB-3rksA:
undetectable		 4xtaB-3rksA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3rks HYDROXYNITRILASE
(Manihot
esculenta) 		5 / 12 ARG A 129
TRP A 128
CYH A  81
THR A  11
LEU A 149
 None
 1.43A 5fhzD-3rksA:
2.9		 5fhzD-3rksA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 3rks HYDROXYNITRILASE
(Manihot
esculenta) 		4 / 6 PRO A  60
ILE A  51
TYR A  57
GLU A  56
 None
 0.80A 6gqiA-3rksA:
undetectable		 6gqiA-3rksA:
20.29