SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rku'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 167
LYS A 172
ALA A 174
VAL A 123
 None
NAP  A 268 (-3.1A)
None
None
 0.88A 1hk1A-3rkuA:
undetectable		 1hk1A-3rkuA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  11
VAL A 151
ASP A 149
VAL A 100
 None
 0.85A 1iwiA-3rkuA:
undetectable		 1iwiA-3rkuA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 168
ILE A  25
GLY A 154
SER A 171
GLY A 199
 NAP  A 268 (-4.8A)
NAP  A 268 (-3.9A)
None
None
NAP  A 268 (-4.7A)
 1.07A 1kiaA-3rkuA:
7.3		 1kiaA-3rkuA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 168
ILE A  25
GLY A 154
SER A 171
GLY A 199
 NAP  A 268 (-4.8A)
NAP  A 268 (-3.9A)
None
None
NAP  A 268 (-4.7A)
 1.08A 1nbhB-3rkuA:
6.9		 1nbhB-3rkuA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 168
ILE A  25
GLY A 154
SER A 171
GLY A 199
 NAP  A 268 (-4.8A)
NAP  A 268 (-3.9A)
None
None
NAP  A 268 (-4.7A)
 1.14A 1nbiA-3rkuA:
7.0		 1nbiA-3rkuA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 168
ILE A  25
GLY A 154
SER A 171
GLY A 199
 NAP  A 268 (-4.8A)
NAP  A 268 (-3.9A)
None
None
NAP  A 268 (-4.7A)
 1.14A 1nbiB-3rkuA:
7.0		 1nbiB-3rkuA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		5 / 9 VAL A 128
LEU A 131
LEU A 195
GLY A 176
ALA A 177
 None
 1.23A 1pxxB-3rkuA:
undetectable		 1pxxB-3rkuA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 128
LEU A 131
LEU A 195
GLY A 176
ALA A 177
 None
 1.22A 1pxxD-3rkuA:
undetectable		 1pxxD-3rkuA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 134
ILE A  86
LEU A  17
ASN A 101
ILE A  98
 None
 1.25A 2nnhB-3rkuA:
undetectable		 2nnhB-3rkuA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		5 / 12 THR A 203
ASN A 127
VAL A 232
ALA A 233
VAL A 151
 NAP  A 268 (-2.5A)
None
None
None
None
 1.14A 2nniA-3rkuA:
undetectable		 2nniA-3rkuA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  28
PHE A 205
ASN A 102
GLY A  20
LEU A 153
 None
NAP  A 268 (-4.0A)
NAP  A 268 (-3.3A)
NAP  A 268 (-3.3A)
NAP  A 268 ( 4.1A)
 1.20A 3aobC-3rkuA:
undetectable		 3aobC-3rkuA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 182
THR A 179
GLY A 154
THR A  19
ILE A 134
 None
 1.44A 3jusB-3rkuA:
undetectable		 3jusB-3rkuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  11
VAL A 151
ASP A 149
VAL A 100
 None
 0.83A 4cp4A-3rkuA:
undetectable		 4cp4A-3rkuA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 248
ILE A 196
GLY A 148
ALA A 239
THR A 240
 None
 1.05A 4enhA-3rkuA:
undetectable		 4enhA-3rkuA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  11
VAL A 151
ASP A 149
VAL A 100
 None
 0.78A 4l4bA-3rkuA:
undetectable		 4l4bA-3rkuA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 130
LEU A  74
ALA A  47
ILE A  86
THR A 126
 None
None
NAP  A 268 (-3.6A)
None
NAP  A 268 ( 3.8A)
 0.91A 4psyA-3rkuA:
undetectable		 4psyA-3rkuA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		3 / 3 GLU A  32
TYR A 238
ARG A 242
 None
 0.80A 5uunA-3rkuA:
1.2		 5uunA-3rkuA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		3 / 3 GLU A  32
TYR A 238
ARG A 242
 None
 0.72A 5uunB-3rkuA:
undetectable		 5uunB-3rkuA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 199
LEU A 200
GLN A 258
PHE A 254
 NAP  A 268 (-4.7A)
None
None
None
 0.82A 5xu8A-3rkuA:
undetectable		 5xu8A-3rkuA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  11
VAL A 151
ASP A 149
VAL A 100
 None
 0.78A 6cp4A-3rkuA:
undetectable		 6cp4A-3rkuA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 3rku OXIDOREDUCTASE
YMR226C
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 236
TYR A  33
VAL A 151
ARG A 192
 None
 1.23A 6f6jA-3rkuA:
undetectable		 6f6jA-3rkuA:
undetectable