SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rkx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		4 / 7 ARG A 227
ASP A 322
ASP A 320
TYR A 182
 None
 1.46A 1ceaB-3rkxA:
undetectable		 1ceaB-3rkxA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		4 / 4 ARG A 255
ALA A 158
ALA A 274
GLU A 270
 None
 1.19A 1e7bA-3rkxA:
undetectable		 1e7bA-3rkxA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		4 / 4 ARG A 255
ALA A 158
ALA A 274
GLU A 270
 None
 1.18A 1e7bB-3rkxA:
undetectable		 1e7bB-3rkxA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		5 / 11 LEU A 249
ILE A  71
GLN A  69
LEU A 213
ARG A 241
 None
 1.13A 2ft9A-3rkxA:
undetectable		 2ft9A-3rkxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		4 / 7 PHE A 244
SER A 169
ILE A 183
GLY A 160
 None
 0.91A 2v0mC-3rkxA:
undetectable		 2v0mC-3rkxA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		4 / 7 TYR A 242
TRP A  67
VAL A  87
TYR A  75
 None
 1.30A 2xz5B-3rkxA:
undetectable
2xz5E-3rkxA:
undetectable		 2xz5B-3rkxA:
20.14
2xz5E-3rkxA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		4 / 7 TYR A 242
TRP A  67
VAL A  87
TYR A  75
 None
 1.32A 2xz5D-3rkxA:
undetectable
2xz5E-3rkxA:
undetectable		 2xz5D-3rkxA:
20.14
2xz5E-3rkxA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		4 / 6 ILE A  71
ILE A 111
TYR A  88
LEU A   9
 None
 1.10A 3adsA-3rkxA:
undetectable		 3adsA-3rkxA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		5 / 12 LEU A  43
SER A  28
ILE A  20
GLY A  57
SER A  52
 None
 1.08A 3kk6A-3rkxA:
0.9		 3kk6A-3rkxA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		5 / 12 LEU A  43
SER A  28
ILE A  20
GLY A  57
SER A  52
 None
 1.03A 3kk6B-3rkxA:
undetectable		 3kk6B-3rkxA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		4 / 8 TYR A 242
TRP A  67
TYR A  75
MET A 137
 None
 1.12A 3wipB-3rkxA:
undetectable
3wipC-3rkxA:
undetectable		 3wipB-3rkxA:
20.54
3wipC-3rkxA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		4 / 8 TYR A 242
TRP A  67
TYR A  75
MET A 137
 None
 1.12A 3wipC-3rkxA:
undetectable
3wipD-3rkxA:
undetectable		 3wipC-3rkxA:
20.54
3wipD-3rkxA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		4 / 8 MET A 137
TYR A 242
TRP A  67
TYR A  75
 None
 1.16A 3wipA-3rkxA:
undetectable
3wipE-3rkxA:
undetectable		 3wipA-3rkxA:
20.54
3wipE-3rkxA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		4 / 8 ASP A 299
ASP A 297
PHE A 264
LEU A 155
 None
 0.91A 4f8hB-3rkxA:
undetectable
4f8hC-3rkxA:
undetectable		 4f8hB-3rkxA:
21.02
4f8hC-3rkxA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		4 / 8 ASP A 299
ASP A 297
PHE A 264
LEU A 155
 None
 0.97A 4f8hC-3rkxA:
undetectable
4f8hD-3rkxA:
undetectable		 4f8hC-3rkxA:
21.02
4f8hD-3rkxA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		4 / 8 ASP A 299
ASP A 297
PHE A 264
LEU A 155
 None
 0.98A 4f8hD-3rkxA:
undetectable
4f8hE-3rkxA:
undetectable		 4f8hD-3rkxA:
21.02
4f8hE-3rkxA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		4 / 8 PHE A 264
LEU A 155
ASP A 299
ASP A 297
 None
 0.95A 4f8hA-3rkxA:
undetectable
4f8hE-3rkxA:
undetectable		 4f8hA-3rkxA:
21.02
4f8hE-3rkxA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		5 / 6 ILE A 211
ILE A 183
SER A 169
PHE A 244
LEU A 239
 None
 1.31A 4m51A-3rkxA:
undetectable		 4m51A-3rkxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		5 / 12 GLY A 190
LEU A 249
PHE A 110
PHE A 244
MET A 137
 None
 1.20A 4ze1A-3rkxA:
undetectable		 4ze1A-3rkxA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		6 / 12 GLY A 190
LEU A 245
ILE A  71
TYR A 242
PHE A 110
MET A 137
 None
 1.37A 5eskA-3rkxA:
undetectable		 5eskA-3rkxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		4 / 5 ILE A 206
PHE A 109
SER A 101
ALA A 204
 None
 0.86A 5msdA-3rkxA:
undetectable		 5msdA-3rkxA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 3rkx BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Staphylococcus
aureus) 		5 / 12 ILE A 252
VAL A 140
LEU A 248
PHE A  82
LEU A 135
 None
 1.24A 6b54A-3rkxA:
undetectable		 6b54A-3rkxA:
23.58