SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rl2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_B_MTXB2278_1
(PTERIDINE REDUCTASE
2)		 3rl2 HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, A-3 ALPHA
CHAIN
(Homo
sapiens) 		5 / 11 ASP A 116
PHE A   9
LEU A 156
THR A 163
TYR A 159
 None
 1.33A 1mxfB-3rl2A:
undetectable		 1mxfB-3rl2A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)		 3rl2 HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, A-3 ALPHA
CHAIN
(Homo
sapiens) 		5 / 11 ASP A 116
PHE A   9
LEU A 156
THR A 163
TYR A 159
 None
 1.33A 1mxfC-3rl2A:
undetectable		 1mxfC-3rl2A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_D_MTXD4278_1
(PTERIDINE REDUCTASE
2)		 3rl2 HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, A-3 ALPHA
CHAIN
(Homo
sapiens) 		5 / 11 ASP A 116
PHE A   9
LEU A 156
THR A 163
TYR A 159
 None
 1.34A 1mxfD-3rl2A:
undetectable		 1mxfD-3rl2A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 3rl2 HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, A-3 ALPHA
CHAIN
(Homo
sapiens) 		3 / 3 TRP A 167
GLU A  63
TYR A  59
 None
 0.96A 2a3aA-3rl2A:
undetectable		 2a3aA-3rl2A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 3rl2 HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, A-3 ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 ALA A 140
GLN A 141
ILE A 142
ARG A 145
 None
 1.43A 2z0aA-3rl2A:
undetectable		 2z0aA-3rl2A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3rl2 HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, A-3 ALPHA
CHAIN
(Homo
sapiens) 		4 / 8 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 0.98A 2zm8A-3rl2A:
undetectable		 2zm8A-3rl2A:
24.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 3rl2 HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, A-3 ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.35A 3uprA-3rl2A:
31.5		 3uprA-3rl2A:
87.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 3rl2 HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, A-3 ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.32A 3uprC-3rl2A:
31.6		 3uprC-3rl2A:
87.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 3rl2 HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, A-3 ALPHA
CHAIN
(Homo
sapiens) 		5 / 12 ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.34A 3vrjA-3rl2A:
32.0
3vrjC-3rl2A:
undetectable		 3vrjA-3rl2A:
87.59
3vrjC-3rl2A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 3rl2 HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, A-3 ALPHA
CHAIN
(Homo
sapiens) 		4 / 5 ASP A  74
PHE A   9
PHE A  22
VAL A  67
 None
 1.01A 5a1rA-3rl2A:
undetectable		 5a1rA-3rl2A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 3rl2 HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, A-3 ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.37A 5u98A-3rl2A:
32.0		 5u98A-3rl2A:
87.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 3rl2 HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, A-3 ALPHA
CHAIN
(Homo
sapiens) 		5 / 10 ILE A  95
TYR A  99
TYR A 123
ILE A 124
TRP A 147
 None
 0.37A 5u98D-3rl2A:
31.9		 5u98D-3rl2A:
87.59