SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rl3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 ASP A  86
HIS A 118
HIS A  67
 MN  A 555 (-2.6A)
5GP  A 951 (-3.8A)
MN  A 444 ( 3.4A)
 0.60A 1oe1A-3rl3A:
undetectable		 1oe1A-3rl3A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 ASP A  86
HIS A 118
HIS A  67
 MN  A 555 (-2.6A)
5GP  A 951 (-3.8A)
MN  A 444 ( 3.4A)
 0.59A 1oe3A-3rl3A:
undetectable		 1oe3A-3rl3A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 TRP A 222
VAL A 223
PRO A 224
 None
5GP  A 951 ( 4.9A)
None
 0.77A 1rg1A-3rl3A:
undetectable		 1rg1A-3rl3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 TRP A 222
VAL A 223
PRO A 224
 None
5GP  A 951 ( 4.9A)
None
 0.78A 1rh0A-3rl3A:
undetectable		 1rh0A-3rl3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		4 / 5 ILE A 203
ARG A 242
LEU A 210
PRO A 245
 None
 1.44A 1s8fA-3rl3A:
undetectable
1s8fB-3rl3A:
undetectable		 1s8fA-3rl3A:
22.70
1s8fB-3rl3A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 LEU A  90
LEU A  92
SER A  94
 None
 0.56A 1tlmA-3rl3A:
undetectable		 1tlmA-3rl3A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 ASP A  86
HIS A 118
HIS A  67
 MN  A 555 (-2.6A)
5GP  A 951 (-3.8A)
MN  A 444 ( 3.4A)
 0.62A 2xxgA-3rl3A:
undetectable		 2xxgA-3rl3A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 ASP A  86
HIS A 118
HIS A  67
 MN  A 555 (-2.6A)
5GP  A 951 (-3.8A)
MN  A 444 ( 3.4A)
 0.63A 2xxgC-3rl3A:
undetectable		 2xxgC-3rl3A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 TYR A 267
VAL A 239
THR A 266
 None
 0.90A 2ygnA-3rl3A:
undetectable		 2ygnA-3rl3A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		4 / 7 PHE A 250
GLY A 252
ASP A 221
ARG A 229
 None
MN  A 555 (-4.2A)
None
CL  A 800 (-3.4A)
 1.24A 3aruA-3rl3A:
undetectable		 3aruA-3rl3A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		4 / 6 VAL A 249
LEU A 217
ILE A  63
ILE A 268
 None
 0.78A 3gcsA-3rl3A:
undetectable		 3gcsA-3rl3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		4 / 4 GLY A  91
VAL A  96
GLY A  85
THR A  84
 None
 0.92A 3ib2A-3rl3A:
undetectable		 3ib2A-3rl3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 PHE A 286
TYR A 267
LEU A  81
 None
 0.69A 3keeB-3rl3A:
undetectable		 3keeB-3rl3A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		5 / 12 SER A 159
LEU A 103
VAL A  96
ALA A 115
PHE A 122
 None
 1.40A 3nuvA-3rl3A:
undetectable		 3nuvA-3rl3A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 PHE A 286
TYR A 267
LEU A  81
 None
 0.53A 3sueB-3rl3A:
undetectable		 3sueB-3rl3A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		4 / 5 PHE A 286
TYR A 267
ILE A 112
LEU A  81
 None
 1.12A 3sueC-3rl3A:
undetectable		 3sueC-3rl3A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 PHE A 277
CYH A 273
HIS A  67
 5GP  A 951 (-4.8A)
None
MN  A 444 ( 3.4A)
 1.30A 3u9fF-3rl3A:
undetectable		 3u9fF-3rl3A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 PHE A 277
CYH A 273
HIS A  67
 5GP  A 951 (-4.8A)
None
MN  A 444 ( 3.4A)
 1.21A 3u9fG-3rl3A:
undetectable		 3u9fG-3rl3A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 PHE A 277
CYH A 273
HIS A  67
 5GP  A 951 (-4.8A)
None
MN  A 444 ( 3.4A)
 1.25A 3u9fL-3rl3A:
undetectable		 3u9fL-3rl3A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 PHE A 277
CYH A 273
HIS A  67
 5GP  A 951 (-4.8A)
None
MN  A 444 ( 3.4A)
 1.24A 3u9fS-3rl3A:
undetectable		 3u9fS-3rl3A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		4 / 6 LEU A 202
LEU A 162
THR A 207
VAL A 243
 None
None
None
MN  A 771 (-4.4A)
 0.95A 4udaA-3rl3A:
undetectable		 4udaA-3rl3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		5 / 8 GLU A 119
HIS A  67
GLY A  85
HIS A 118
HIS A 254
 None
MN  A 444 ( 3.4A)
None
5GP  A 951 (-3.8A)
MN  A 444 ( 3.5A)
 1.24A 5f8yB-3rl3A:
undetectable		 5f8yB-3rl3A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		3 / 3 ARG A  59
ILE A  80
PHE A  60
 None
 0.75A 5kirA-3rl3A:
undetectable		 5kirA-3rl3A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3rl3 METALLOPHOSPHOESTERA
SE MPPED2
(Rattus
norvegicus) 		4 / 6 ASP A  86
HIS A  67
HIS A 254
HIS A 213
 MN  A 555 (-2.6A)
MN  A 444 ( 3.4A)
MN  A 444 ( 3.5A)
MN  A 555 (-3.5A)
 1.03A 5nelB-3rl3A:
undetectable
5nelC-3rl3A:
undetectable		 5nelB-3rl3A:
24.08
5nelC-3rl3A:
24.08