SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rl7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MUI_B_AB1B100_2 (PROTEASE)	3rl7	DISKS LARGE HOMOLOG 1 (Homo sapiens)	6 / 12	GLY B 235 ALA B 264 ASP B 267 ILE B 225 VAL B 272 ILE B 258	None	1.33A	1muiB-3rl7B: undetectable	1muiB-3rl7B: 13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SG9_A_SAMA301_1 (HEMK PROTEIN)	3rl7	DISKS LARGE HOMOLOG 1 (Homo sapiens)	4 / 4	THR B 256 GLY B 241 ASP B 243 ALA B 292	None	1.24A	1sg9A-3rl7B: undetectable	1sg9A-3rl7B: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NMZ_B_ROCB401_1 (PROTEASE)	3rl7	DISKS LARGE HOMOLOG 1 (Homo sapiens)	6 / 12	GLY B 235 ALA B 264 ASP B 267 ILE B 225 ILE B 238 ILE B 258	None	1.42A	2nmzA-3rl7B: undetectable	2nmzA-3rl7B: 14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FL9_B_TOPB200_1 (DIHYDROFOLATE REDUCTASE (DHFR))	3rl7	DISKS LARGE HOMOLOG 1 (Homo sapiens)	5 / 12	ALA B 299 LEU B 234 LEU B 305 VAL B 279 ILE B 238	None	1.11A	3fl9B-3rl7B: undetectable	3fl9B-3rl7B: 21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K4V_B_ROCB201_1 (HIV-1 PROTEASE)	3rl7	DISKS LARGE HOMOLOG 1 (Homo sapiens)	6 / 12	GLY B 262 ALA B 264 ASP B 267 ILE B 225 VAL B 272 ILE B 258	None	1.47A	3k4vA-3rl7B: undetectable	3k4vA-3rl7B: 13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NDT_A_ROCA101_1 (PROTEASE)	3rl7	DISKS LARGE HOMOLOG 1 (Homo sapiens)	6 / 12	GLY B 262 ALA B 264 ASP B 267 ILE B 225 VAL B 272 ILE B 258	None	1.45A	3ndtA-3rl7B: undetectable	3ndtA-3rl7B: 13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TZO_B_7V7B201_1 (ENDO-1,4-BETA-XYLANA SE A)	3rl7	DISKS LARGE HOMOLOG 1 (Homo sapiens)	5 / 12	LEU B 305 SER B 301 VAL B 303 ALA B 299 GLY B 300	None	1.18A	5tzoB-3rl7B: undetectable	5tzoB-3rl7B: 18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DWD_A_GLYA715_0 (DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1)	3rl7	DISKS LARGE HOMOLOG 1 (Homo sapiens)	4 / 6	GLY B 241 ASN B 244 ASP B 243 SER B 290	None	1.10A	6dwdA-3rl7B: undetectable 6dwdC-3rl7B: undetectable	6dwdA-3rl7B: 14.77 6dwdC-3rl7B: 14.77

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MUI_B_AB1B100_2","PROTEASE","3rl7","DISKS LARGE HOMOLOG 1","Homo sapiens",6,"GLY B 235;ALA B 264;ASP B 267;ILE B 225;VAL B 272;ILE B 258","None","1.33A","1muiB-3rl7B:undetectable","1muiB-3rl7B:13.08"],["1SG9_A_SAMA301_1","HEMK PROTEIN","3rl7","DISKS LARGE HOMOLOG 1","Homo sapiens",4,"THR B 256;GLY B 241;ASP B 243;ALA B 292","None","1.24A","1sg9A-3rl7B:undetectable","1sg9A-3rl7B:19.35"],["2NMZ_B_ROCB401_1","PROTEASE;PROTEASE","3rl7","DISKS LARGE HOMOLOG 1","Homo sapiens",6,"GLY B 235;ALA B 264;ASP B 267;ILE B 225;ILE B 238;ILE B 258","None","1.42A","2nmzA-3rl7B:undetectable","2nmzA-3rl7B:14.95"],["3FL9_B_TOPB200_1","DIHYDROFOLATE REDUCTASE (DHFR)","3rl7","DISKS LARGE HOMOLOG 1","Homo sapiens",5,"ALA B 299;LEU B 234;LEU B 305;VAL B 279;ILE B 238","None","1.11A","3fl9B-3rl7B:undetectable","3fl9B-3rl7B:21.08"],["3K4V_B_ROCB201_1","HIV-1 PROTEASE;HIV-1 PROTEASE","3rl7","DISKS LARGE HOMOLOG 1","Homo sapiens",6,"GLY B 262;ALA B 264;ASP B 267;ILE B 225;VAL B 272;ILE B 258","None","1.47A","3k4vA-3rl7B:undetectable","3k4vA-3rl7B:13.08"],["3NDT_A_ROCA101_1","PROTEASE","3rl7","DISKS LARGE HOMOLOG 1","Homo sapiens",6,"GLY B 262;ALA B 264;ASP B 267;ILE B 225;VAL B 272;ILE B 258","None","1.45A","3ndtA-3rl7B:undetectable","3ndtA-3rl7B:13.08"],["5TZO_B_7V7B201_1","ENDO-1,4-BETA-XYLANASE A","3rl7","DISKS LARGE HOMOLOG 1","Homo sapiens",5,"LEU B 305;SER B 301;VAL B 303;ALA B 299;GLY B 300","None","1.18A","5tzoB-3rl7B:undetectable","5tzoB-3rl7B:18.62"],["6DWD_A_GLYA715_0","DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1","3rl7","DISKS LARGE HOMOLOG 1","Homo sapiens",4,"GLY B 241;ASN B 244;ASP B 243;SER B 290","None","1.10A","6dwdA-3rl7B:undetectable;6dwdC-3rl7B:undetectable","6dwdA-3rl7B:14.77;6dwdC-3rl7B:14.77"]]