SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rle'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Homo
sapiens) 		5 / 11 LEU A  96
GLY A  97
SER A  99
ILE A 100
LEU A  55
 None
 0.75A 2kawA-3rleA:
3.9		 2kawA-3rleA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Homo
sapiens) 		5 / 10 TRP A 113
VAL A 115
ILE A 194
LEU A 149
ALA A 139
 None
 1.06A 2xf3A-3rleA:
undetectable		 2xf3A-3rleA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Homo
sapiens) 		4 / 5 TYR A  17
ILE A  40
LEU A  96
LEU A  59
 None
 1.16A 2zb7A-3rleA:
undetectable		 2zb7A-3rleA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Homo
sapiens) 		4 / 6 LYS A   7
ILE A   9
VAL A  41
LEU A  70
 None
 0.97A 4em2A-3rleA:
undetectable		 4em2A-3rleA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Homo
sapiens) 		3 / 3 GLU A 157
LYS A 159
ASN A 181
 None
 0.93A 4y1dA-3rleA:
undetectable
4y1dD-3rleA:
undetectable		 4y1dA-3rleA:
24.77
4y1dD-3rleA:
31.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Homo
sapiens) 		5 / 10 ALA A 124
ALA A 127
VAL A 176
LEU A 149
VAL A 165
 None
 1.45A 5eb5B-3rleA:
undetectable		 5eb5B-3rleA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Homo
sapiens) 		3 / 3 THR A 168
SER A 133
TYR A 135
 None
 0.75A 5jsdA-3rleA:
undetectable		 5jsdA-3rleA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Homo
sapiens) 		3 / 3 THR A 168
SER A 133
TYR A 135
 None
 0.75A 5jsdB-3rleA:
undetectable		 5jsdB-3rleA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Homo
sapiens) 		3 / 3 THR A 168
SER A 133
TYR A 135
 None
 0.75A 5jsdC-3rleA:
undetectable		 5jsdC-3rleA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Homo
sapiens) 		3 / 3 THR A 168
SER A 133
TYR A 135
 None
 0.76A 5jseA-3rleA:
undetectable		 5jseA-3rleA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Homo
sapiens) 		3 / 3 THR A 168
SER A 133
TYR A 135
 None
 0.77A 5jseB-3rleA:
undetectable		 5jseB-3rleA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 3rle GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Homo
sapiens) 		3 / 3 THR A 168
SER A 133
TYR A 135
 None
 0.77A 5jseC-3rleA:
undetectable		 5jseC-3rleA:
15.20